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Journal of Dental Research
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The Influence of 5-Hydroxytryptamine (Serotonin) on Blood Flow in the Dog Pulp

S. Kim

Laboratory of Oral Physiology and Department of Endodontics, School of Dental and Oral Surgery, Columbia University, New York, New York 10032

H.O. Trowbridge

Department of Pathology, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104

J.E. Dorscher-Kim

Laboratory of Oral Physiology and Department of Endodontics, School of Dental and Oral Surgery, Columbia University, New York, New York 10032

The effect of intra-arterial injection of 5-hydroxytryptamine (5-HT) on pulpal blood flow of the dog was determined using the 15-µm radioisotope-labeled microsphere injection method. Pulpal blood flow was significantly reduced following the 5-HT injection. This decrease in blood flow appeared to be due to vasoconstriction as determined by an increase in pulpal vascular hindrance. However, our findings do not preclude the possibility that blood flow was reduced as a result of passive compression of venules produced by vasodilation in a low-compliance environment.

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Journal of Dental Research, Vol. 65, No. 5, 682-685 (1986)
DOI: 10.1177/00220345860650051001
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This Article
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Citing Articles
Right arrow Citing Articles via Google Scholar
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Right arrow Articles by Kim, S.
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PubMed
Right arrow PubMed Citation
Right arrow Articles by Kim, S.
Right arrow Articles by Dorscher-Kim, J.E.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?