|
Sign In to gain access to subscriptions and/or personal tools.
|
Oral Mucosal Langerhans Cells Express DR and DQ Antigens
L.J. Walsh
Departments of Social and Preventive Dentistry, and Oral Biology and Oral Surgery
G.J. Seymour
Departments of Social and Preventive Dentistry, and Oral Biology and Oral Surgery
N.W. Savage
University of Queensland Dental School, Turbot Street, Brisbane, QLD 4000, Australia
The expression of the Class II antigens HLA-DR and HLA-DQ in human oral mucosa was examined in health and in the presence of inflammation. DQ antigens were detected on dendritic intra-epithelial cells which expressed the Langerhans cells (LC) phenotype T6+, DR+. In healthy gingiva, DR and DQ were co-expressed on Langerhans cells, whereas in an experimental gingivitis (day 8), more LC expressed DR than DQ. Absolute LC numbers were increased in inflammation. Traumatic ulceration of the buccal mucosa resulted in a decrease in the density of T6-, DR-, and DQ-positive cells. Re-population of migrating and regenerated epithelium was complete 10 days after ulcer induction. Disparity between DR and DQ expression was seen in both normal buccal mucosa and throughout the ulcer healing period. These results are in agreement with the reported sequence of Class II antigen expression on lymphoid cells.
REFERENCES
- Bach, F.H. (1985): The HLA Class II Genes and Products: The HLA-D Region, Immunol Today 6:89-94.[CrossRef]
- Bos, I.R. and Burkhardt, A. (1980): Interepithelial Cells of the Oral Mucosa. Light and Electron Microscopic Observations in Germfree, Specific Pathogen-free and Conventionalized Mice, J Oral Pathol 9:65-81.
- Difranco, C.F.; Toto, P.D.; Rowden, G.; Gargiulo, A.W.: Keene, J.J.; and Connelly, E. (1985): Identification of Langerhans Cells in Human Gingival Epithelium, J Periodont 56:48-54.[Medline]
[Order article via Infotrieve]
- Graham, R.C. and Karnovsky, M.J. (1966): The Early Stages of Absorption of Injected Horseradish Peroxidase in the Proximal Tubules of Mouse Kidney: Ultrastructural Cytochemistry by a New Technique, J Histochem Cytochem 14:291-302.[Abstract]
- Guy, K.; Ritchie, A.W.S.; Van Heyningen, V.; and Dewar, A.E. (1983): Further Serological Characterization of the Heterogeneity of Expression of Human MHC Class II Antigens: Chronic Lymphocytic Leukaemia Cells and Monocytes Differentially Express DR and DC Antigens, Disease Markers 1:249-262.
- Guy, K. and Van Heyningen, V. (1983): An Ordered Sequence of Expression of Human MHC Class II Antigens During B Cell Maturation?, Immunol Today 4:186-189.[CrossRef]
- Hsu, S.M. and Raine, L. (1981): Protein A, Avidin and Biotin in Immunohistochemistry, J Histochem Cytochem 29:1349-1353.[Abstract]
- Klein, J. and Hauptfeld, V. (1976): Ia Antigens: Their Serology, Molecular Relationships, and Their Role in Allograft Reactions, Transplant Rev 30:83-100.[Medline]
[Order article via Infotrieve]
- Löe, H.; Theilade, E.; and Jensen, S.B. (1965): Experimental Gingivitis in Man, J Periodont 36:177-187.
- Murphy, G.F. (1982): Monoclonal Anti-T6 Antibody and Langerhans Cells, Br J Derm 107:487-489.[CrossRef][Medline]
[Order article via Infotrieve]
- Newcomb, G.M.; Seymour, G.J.; and Powell, R.N. (1982): Association Between Plaque Accumulation and Langerhans Cell Numbers in the Oral Epithelium of Attached Gingiva, J Clin Periodont 9:297-304.[CrossRef][Medline]
[Order article via Infotrieve]
- Savage, N.W.; Seymour, G.J.; and Kruger, B.J. (1986): Expression of Class I and Class II Major Histocompatibility Complex Antigens on Epithelial Cells in Recurrent Aphthous Stomatitis, J Oral Pathol (in press).
- Seymour, G.J.; Powell, R.N.; Cole, K.L.; Aitken, J.F.; Brooks, D.; Beckman, I.; Zola, H.; Bradley, J.; and Burns, G.F. (1983): Experimental Gingivitis in Humans. A Histochemical and Immunological Characterization of the Lymphoid Cell Subpopulations, J Periodont Res 18:375-385.[CrossRef][Medline]
[Order article via Infotrieve]
- Tamaki, K.; Stingl, G.; and Katz, S.I. (1980): The Origin of Langerhans Cells, J Invest Derm 74:309-311.[CrossRef][Medline]
[Order article via Infotrieve]
- Thorbecke, G.J.; Silverberg-Sinakin, I.; and Flotte, T.J. (1980): Langerhans Cells as Macrophages in Skin and Lymphoid Organs, J Invest Derm 75:32-43.[CrossRef][Medline]
[Order article via Infotrieve]
- Trowsdale, J.; Lee, J.; and McMichael, A. (1983): HLA-DR Bouillabaisse, Immunol Today 4:31-35.[CrossRef]
- Walsh, L.J.; Powell, R.N.; Seymour, G.J.; and Newcomb, G.M. (1984): Loss of Langerhans Cells from Gingival Tissue Maintained in Organ Culture, J Oral Pathol 13:604-613.[CrossRef][Medline]
[Order article via Infotrieve]
- Walsh, L.J.; Seymour, G.J.; and Powell, R.N. (1985a): Gingival Keratinocytes Express HLA-DR Antigens in Chronic Gingivitis, J Oral Pathol 14:315-321.[CrossRef][Medline]
[Order article via Infotrieve]
- Walsh, L.J.; Seymour, G.J.; Bird, P.S.; and Powell, R.N. (1985b): Modulation of HLA-DR Antigens in the Gingival Epithelium in vitro by Heat Killed Fusobacterium nucleatum and E. coli Lipopolysaccharide, J Oral Pathol 14:833-843.[CrossRef][Medline]
[Order article via Infotrieve]
- Wang, C.Y.; Al-Katib, A.; Lane, C.L.; Koziner, B.; and Fu, S.M. (1983): Induction of HLA-DC/DS (Leu 10) Antigen Expression by Human Precursor B Cell Lines, J Exp Med 158:1757-1762.[Abstract/Free Full Text]
Journal of Dental Research, Vol. 65, No. 3,
390-393 (1986)
DOI: 10.1177/00220345860650030301
 CiteULike  Complore  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter What's this?
This article has been cited by other articles:
|
|
|
|
 
L.J. Walsh, P.E. Lander, G.J. Seymour, and R.N. Powell
In vitro Modulation of T6 Expression on Gingival Langerhans Cells by Interleukin-1 Inhibitors and ETAF
Journal of Dental Research,
March 1, 1987;
66(3):
766 - 769.
[Abstract]
[PDF]
|
|
|
|
|
|
|
L.J. Walsh, G.J. Seymour, and R.N. Powell
Interleukin-1 Modulates T6 Expression on a Putative Intra-epithelial Langerhans Cell Precursor Population
Journal of Dental Research,
December 1, 1986;
65(12):
1424 - 1426.
[Abstract]
[PDF]
|
|
|
|
|
