Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

CiteULike is a free service for managing and discovering scholarly references - click here to get started.

Sign In to gain access to subscriptions and/or personal tools.
Journal of Dental Research
This Article
Right arrow Abstract Freely available
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Bobyock, E.
Right arrow Articles by Chernick, W.S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bobyock, E.
Right arrow Articles by Chernick, W.S.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Effects of Substance P and Substance P Antagonists on Rat Salivary Secretion

E. Bobyock

Hahnemann University, Department of Pharmacology, Broad and Vine, Philadelphia, Pennsylvania 19102

E.J. Barbieri

Hahnemann University, Department of Pharmacology, Broad and Vine, Philadelphia, Pennsylvania 19102

W.S. Chernick

Hahnemann University, Department of Pharmacology, Broad and Vine, Philadelphia, Pennsylvania 19102

The intra-arterial infusion of substance P produced dose-related responses of both parotid and submandibular salivary secretion in anesthetized rats. The substance P-induced secretion in both glands was inhibited by the substance P analogues [D-Arg 1, D-Trp7,9, Leu11]-substance P and [D-Arg1, D-Pro2, D-Trp7,9, Leu11]-substance P, but not by [D-Pro2 , D-Trp7,9]-substance P. The profiles of protein and calcium levels obtained with substance P-induced salivary secretion for both glands were similar to those produced by acetylcholine stimulation and were not altered by the substance P analogues.

REFERENCES

  • Bahouth, S.W. and Musacchio, J.E. (1985): Specific Binding of [3H] Substance P to the Rat Submaxillary Gland. The Effects of Ions and Guanine Nucleotides, J Pharmacol Exp Ther 234:326-336.[Abstract/Free Full Text]
  • Bjorkroth, U.; Rosell, S.; Xu, J.C.; and Folkers, K. (1982): Pharmacological Characterization of Four Related Substance P Antagonists, Acta Physiol Scand 116:167-173.[Medline] [Order article via Infotrieve]
  • Bobyock, E.; Barbieri, E.J.; and Chernick, W.S. (1985a): In vivo Inhibition of Substance P [SP]-Induced Salivary Secretion by Spantide, an SP Antagonist, The Pharmacologist Abst 27:146.
  • Bobyock, E.; Chernick, W.S.; and Digregorio, G.J. (1985b): The Mouse Parotid Gland Preparation: An in vivo Pharmacological Tool, J Dent Res 64:1121-1125.[Abstract/Free Full Text]
  • Bradford, M.M. (1976): A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding, Anal Biochem 72:248-254.[CrossRef][Medline] [Order article via Infotrieve]
  • Buck, S.H.; Burcher, E.; Shults, C.W.; Lovenberg, W.; and O'Donohue, T.L. (1984): Novel Pharmacology of Substance K-Binding Sites: A Third Type of Tachykinin Receptor, Science 226:987-989.[Abstract/Free Full Text]
  • Ekstrom, J.; Masson, B.; and Tobin, G. (1983): Relative Secretory Contributions of the Three Major Salivary Glands of the Rat in Response to Substance P and Super-Sensitivity, Arch Oral Biol 28:859-863.[CrossRef][Medline] [Order article via Infotrieve]
  • Ekstrom, J. and Wahlestedt, C. (1982): Supersensitivity to Substance P and Physalaemin in Rat Salivary Glands after Denervation or Decentralization, Acta Physiol Scand 115:437-446.[Medline] [Order article via Infotrieve]
  • Emmelin, N.; Schneyer, C.A.; and Schneyer, L.H. (1973): The Pharmacology of Salivary Secretion. In: Pharmacology of Gastrointestinal Motility and Secretion, International Encyclopedia of Pharmacology and Therapeutics, Sect. 39A, Vol. 1, Oxford: Pergamon, pp. 1-39.
  • Ersparmer, V. (1981): Tachykinin Peptide Family, Trends Neurosci 4:267-269.[CrossRef]
  • Fleming, N.; Bilan, P.T.; and Graham, K.W. (1984): Effect of Substance P on Exocrine Secretion by Rat Submandibular Cells, J Dent Res 63:1022-1027.[Abstract/Free Full Text]
  • Folkers, K.; Hakanson, R.; Horig, J.; Jie-Cheng, X.; and Leander, S. (1984): Biological Evaluation of Substance P Antagonists, Br J Pharmacol 83:449-456.
  • Gallacher, D.V. (1983): Substance P is a Functional Neurotransmitter in the Rat Parotid Gland, J Physiol (Lond ) 342:483-498.[Abstract/Free Full Text]
  • Inoki, R.; Kudo, T.; Kotani, Y.; Oka, M.; Iwatsubo, K.; and Matsumoto, M. (1979): Mechanism of Substance-P Induced Salivary Secretion in Rats, Adv Exp Med Biol 120:409-420.
  • Jirakulsomchok, D.; Yu, J.H.; and Schneyer, C.A. (1984): Effects of Substance P on Na and K Transport in Perfused Main Submandibular Duct of Rat, Proc Soc Exp Biol Med 177:165-167.[CrossRef][Medline] [Order article via Infotrieve]
  • Leeman, S.E. and Hammerschlag, R. (1967): Stimulation of Salivary Secretion by a Factor Extracted From Hypothalamic Tissue, Endocrinol 81:803-810.[Abstract/Free Full Text]
  • Maggi, C.A.; Giuliani, S.; Santicioli, P.; Regoli, D.; and Meli, A. (1985): Comparison of the Effects of Substance P and Substance K on Blood Pressure, Salivation and Urinary Bladder Motility in Urethane-Anesthetized Rats, Eur J Phamacol 113:291-294.[Medline] [Order article via Infotrieve]
  • Martinez, J.R. and Martinez, A.M. (1981): Stimulatory and Inhibitory Effects of Substance P on Rat Submandibular Secretion, J Dent Res 60:1031-1038.[Abstract/Free Full Text]
  • Murray, C.W.; Hanau, C.; Cowan, A.; Vaught, J.L.; Wright, D.; and Jacoby, H. (1985): Differentiation of Specific Mammalian Tachykinin (T) Receptors Using a Novel Selective Antagonist, The Pharmacologist Abst 27:180.
  • Putney, J.W., Jr. (1977): Muscarinic, a-Adrenergic and Peptide Receptors Regulate the Same Calcium Influx Sites in the Parotid Gland, J Physiol (Lond) 268:139-149.[Abstract/Free Full Text]
  • Ross, E.M. and Gilman, A.G. (1985): Pharmacodynamics: Mechanisms of Drug Action and the Relationship Between Concentration and Effect. In: The Pharmacological Basis of Therapeutics, 7th ed., A. Gilman, L. Goodman, T. Rail, and F. Murad, Eds., New York: MacMillan, pp. 35-48.
  • Strittmatter, W.J.; Davis, J.M.; and Lefkowitz, R.J. (1977): Alpha-adrenergic Receptors in Rat Parotid Cells: II. Desensitization of Receptor Binding Sites and Potassium Release, J Biol Chem 252:5478-5482.[Free Full Text]
  • Takano, Y.; Takeda, Y.; Doteuchi, M.; Inouye, K.; and Kamiya, M. (1985): Effect of a Novel Tachykinin, Substance K, on Salivation in Rats, Eur J Pharmacol 111:381-383.[Medline] [Order article via Infotrieve]
  • Tallarida, J.R. and Murray, R.B. (1981): Manual of Pharmacological Calculations With Computer Programs, New York: Springer-Verlag, p. 12.
  • Thulin, A. (1976): Secretory and Motor Effects in the Submaxillary Gland of the Rat on Intraarterial Administration of Some Polypeptides and Autonomic Drugs, Acta Physiol Scand 97:343-348.[Medline] [Order article via Infotrieve]
  • Willis, J.B. (1960): The Determination of Metals in Blood Serum by Atomic Absorption Spectroscopy -I. (Calcium), Spectrochim Acta 16:259-272.[CrossRef]
  • Yu, J.H.; Burns, S.M.; and Schneyer, C.A. (1983): Salivary Secretion Induced by Substance P, Proc Soc Exp Biol Med 173:467-470.[CrossRef][Medline] [Order article via Infotrieve]

Journal of Dental Research, Vol. 65, No. 12, 1427-1431 (1986)
DOI: 10.1177/00220345860650121001
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 JDRHome page
E. Bobyock and W.S. Chernick
Vasoactive Intestinal Peptide Interacts with Alpha-adrenergic-, Cholinergic-, and Substance-P-mediated Responses in Rat Parotid and Submandibular Glands
Journal of Dental Research, November 1, 1989; 68(11): 1489 - 1494.
[Abstract] [PDF]

Home page
 JDRHome page
W. Chernick, E. Bobyock, and P. Bradford
5-Hydroxytryptamine Modulation of Rat Parotid Salivary Gland Secretion
Journal of Dental Research, January 1, 1989; 68(1): 59 - 63.
[Abstract] [PDF]

This Article
Right arrow Abstract Freely available
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Bobyock, E.
Right arrow Articles by Chernick, W.S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bobyock, E.
Right arrow Articles by Chernick, W.S.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?