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Failure of PTH, Calcitonin, or Vitamin D Metabolites to Influence Calcium Transport in the Maturation Stage Enamel Organ

The Dental Research Center and The Department of Pedodontics. University of North Carolina, Chapel Hill, North Carolina 27514

T.G. Deaton

The Dental Research Center and The Department of Pedodontics. University of North Carolina, Chapel Hill, North Carolina 27514

D.A. Timko

The Dental Research Center and The Department of Pedodontics. University of North Carolina, Chapel Hill, North Carolina 27514

M.A. Crenshaw

The Dental Research Center and The Department of Pedodontics. University of North Carolina, Chapel Hill, North Carolina 27514

Eleven-day-old rat maxillary first molar explants were removed by microdissection and incubated in vitro to determine the direct effects of parathyroid hormone (PTH), calcitonin (CT), 1,25(OH)₂D₃, 24.25(OH) ₂D₃, and a combination of PTH and vitamin D ₃ metabolites on calcium uptake in the mineralizing enamel of the explants. None of the agents had a statistically significant effect. These results are in contrast to those observed on explants from six-day-old rats, where PTH + 24,25(OH)₂D₃ caused a significant increase in net calcium transport. The findings are consistent with the hypothesis that the transcellular transport of calcium through the secretory stage and the maturation stage ameloblasts occurs by different mechanisms.

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Journal of Dental Research, Vol. 64, No. 9, 1138-1140 (1985)
DOI: 10.1177/00220345850640090801


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This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Bawden, J.W. Articles by Crenshaw, M.A. Search for Related Content PubMed Articles by Bawden, J.W. Articles by Crenshaw, M.A. Social Bookmarking                         What's this?