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Comparisons of Various Salivary Parameters in Smokers Before and After the Use of a Nicotine-containing Chewing Gum

Oral Health Research Institute, Indiana University School of Dentistry, 415 North Lansing Street, Indianapolis, Indiana 46202

J.L. McDonald, Jr

Oral Health Research Institute, Indiana University School of Dentistry, 415 North Lansing Street, Indianapolis, Indiana 46202

M.J. Gleason

Oral Health Research Institute, Indiana University School of Dentistry, 415 North Lansing Street, Indianapolis, Indiana 46202

G.K. Stookey

Oral Health Research Institute, Indiana University School of Dentistry, 415 North Lansing Street, Indianapolis, Indiana 46202

B.R. Schemehorn

Oral Health Research Institute, Indiana University School of Dentistry, 415 North Lansing Street, Indianapolis, Indiana 46202

C.A. Drook

Oral Health Research Institute, Indiana University School of Dentistry, 415 North Lansing Street, Indianapolis, Indiana 46202

B.B. Beiswanger

Oral Health Research Institute, Indiana University School of Dentistry, 415 North Lansing Street, Indianapolis, Indiana 46202

A.G. Christen

Oral Health Research Institute, Indiana University School of Dentistry, 415 North Lansing Street, Indianapolis, Indiana 46202

This study was designed to compare various salivary parameters between smokers and non-smokers and to determine the influence of a nicotine-containing chewing gum (used to aid in quit-smoking efforts) upon these same parameters. At the baseline examination, subjects were assigned to one of three groups: non-smokers who did not utilize any gum, smokers provided a nicotine-containing gum, and smokers provided a placebo gum. Saliva was collected from all subjects and analyzed for acidogenicity and buffer pH as well as for levels of thiocyanate, lactoperoxidase, lysozyme, lactoferrin, and secretory IgA. After 15 weeks of gum usage, saliva was again collected from each subject and the identical analyses performed. Significant differences were observed between smokers and non-smokers with regard to three parameters: The saliva of smokers contained greater concentrations of thiocyanate and lower concentrations of lactoferrin, at the baseline examination and after the 15-week test period. In addition, the CO content of alveolar air was higher in smokers at both examination periods. In contrast, the use of the nicotine gum per se had no effect on any of the test parameters.

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Journal of Dental Research, Vol. 64, No. 5, 826-830 (1985)
DOI: 10.1177/00220345850640050901


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This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Olson, B.L. Articles by Christen, A.G. Search for Related Content PubMed PubMed Citation Articles by Olson, B.L. Articles by Christen, A.G. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Hazardous Substances DB CARBON MONOXIDE NICOTINE NICOTINE TARTRATE Medline Plus Health Information Smoking Social Bookmarking                         What's this?