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A Comparison of the Antibacterial and Cytotoxic Effects of Parachlorophenoll

School of Dentistry, University of Minnesota, 8-166 Moos Tower, Minneapolis, Minnesota 55455

R.J. Feigal

School of Dentistry, University of Minnesota, 8-166 Moos Tower, Minneapolis, Minnesota 55455

The antibacterial and cytotoxic effects of para chlorophenol (as 35% camphorated PCP and 2% aqueous PCP) were compared directly, using the agar overlay technique. Human pulp fibroblasts and L929 cells were grown to confluence in 60-mm petri dishes. Bacterial suspensions (S. aureus, E. coli) in agar were poured as a thin layer in 60-mm petri dishes. All were overlaid with agar. Cells were exposed to medicament via filter paper discs placed on the agar surface. After 24 hours, the zone of cell lysis (fibroblasts) or inhibition of bacterial growth was measured as diameter in mm. A dose-response relationship was observed for both fibroblasts and bacteria. The zone of inhibition for fibroblasts was larger than that for bacteria, indicating that the cytotoxicity of parachlorophenol exceeds its antibacterial activity.

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Journal of Dental Research, Vol. 64, No. 5, 818-821 (1985)
DOI: 10.1177/00220345850640050701


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This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Messer, H.H. Articles by Feigal, R.J. Search for Related Content PubMed PubMed Citation Articles by Messer, H.H. Articles by Feigal, R.J. Social Bookmarking                         What's this?