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Immediate and Delayed Effects of an Enzyme-dependent Mineralizing Mouthrinse on Dental Plaque
R.G. Schamschula
Institute of Dental Research, 2 Chalmers Street, Surry Hills, N.S.W., 2010, Australia
E.I.F. Pearce
Dental Unit, Medical Research Council of NZ, P.O. Box 27007, Wellington, New Zealand
P.S.H. Un
Institute of Dental Research, 2 Chalmers Street, Surry Hills, N.S.W., 2010, Australia
M.H. Cooper
Health Commission of New South Wales, P.O. Box 790, Dubbo, N.S. W., 2830, Australia
Twenty-two children aged 13 to 14 years rinsed for 3 x 1 min periods with a supersaturated cadcium phosphate solution containing urea and monofluorophosphate. Plaque sampled one min after the last rinse showed a marked increase in water-extractable F and a smaller increase in Ca but no increase in water-extractable P. Water-insoluble forms of all three ions were elevated, however. The mean pdaque pH was 8.28. Plaque sampled 24 hr after the last rinse showed significant increases in water-insoluble F and Ca only, and no increase in pH. The prompt pH rise and disappearance of watersoluble P suggest that, on exposure to the mineralizing solution, urea and monofluorophosphate are rapidly hydrolyzed by plaque enzymes to provide catabolites which cause the immediate precipitation of fluoridated calcium phosphate.
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Journal of Dental Research, Vol. 64, No. 3,
454-456 (1985)
DOI: 10.1177/00220345850640031301
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