|
Sign In to gain access to subscriptions and/or personal tools.
|
Pharmacokinetics of Chronic Fluoride Ingestion in Growing Pigs
A. Richards
Department of Dental Pathology and Operative Dentistry, The Royal Dental College
J. Kragstrup
Institute of Pharmacology, University of Aarhus, 8000 Aarhus C, Denmark
F. Nielsen-Kudsk
Department of Dental Pathology and Operative Dentistry, The Royal Dental College
The present study was undertaken to estimate bio-availability and biological half-life of fluoride and accumulation of fluoride in bone in the domestic pig. Eight animals receiving 2 mg F-/kg b.w. per day from age 8 to 14 months were compared with eight controls.
Plasma fluoride concentrations just prior to the daily oral dose were measured at regular intervals. After 112 days post-dose, plasma fluoride levels were measured over a 48-hour period following the daily oral dose or a single intravenous dose. Mean bio-availability factor for the oral dose was 0.3 (range 0.2-0.4), and mean biological half-life was 59 days (range 49- 72). Bone fluoride content calculated from the pharmacokinetic parameters derived from plasma data was similar to the content of fluoride measured in the bone at slaughter.
The study showed that accumulation of fluoride in bone influences plasma fluoride levels during chronic administration of fluoride to growing pigs. The long biological half-life found showed that it was not possible to achieve steady-state plasma levels within the six-month experimental period used. This means that, for dose-response studies of dental fluorosis in this animal, it is not possible to achieve steady-state plasma concentrations as a basis for correlations to the degrees of pathological change observed in the teeth.
REFERENCES
- Charkes, N.D.; Brookes, M.; and Makler, P.T., Jr. (1979): Studies of Skeletal Tracer Kinetics: II. Evaluation of a Five Compartment Model of (18F) Fluoride Kinetics in Rats, J Nuc Med 20:1150-1157.[Abstract/Free Full Text]
- Ekstrand, J.; Alvan, G.; Boreus, L.L.; and Norlin, A. (1977): Pharmacokinetics of Fluoride in Man After Single and Multiple Oral Doses, Eur J Clin Pharmacol 12:311-317.[CrossRef][Medline]
[Order article via Infotrieve]
- Ekstrand, J.; Koch, G.; Lindgren, L.E.; and Petersson, L.G. (1981): Pharmacokinetics of Fluoride Gels in Children and Adults, Caries Res 15:213-220.[Medline]
[Order article via Infotrieve]
- Ekstrand, J. (1983): Use of Pharmacokinetic Models and Techniques in Fluoride Research. In: Fluoride Effects on Vegetation, Animals, and Humans, Shupe, J.L., Peterson, H.B., Leone, N.C., Eds., Salt Lake City: Paragon Press, Inc., pp. 259-270.
- Fry, B.W. and Taves, D.R. (1970): Serum Fluoride Analysis with the Fluoride Electrode, J Lab Clin Med 75:1020-1025.[Medline]
[Order article via Infotrieve]
- Fuchs, C.; Haase, W.; and Maurer, H. (1984): Pharmakokinetik eines Fluorid-kalzium- Praparates zur Behandlung der Osteoporose, Arzneim-Forsch/Drug Res 34:832-835.
- Gibaldi, M. and Perrier, D. (1975): Pharmacokinetics, Vol. 1. New York: Marcel Dekker, Inc.
- Guy, W.S.; Taves, D.R.; and Brey, W.S., Jr. (1976): Organic Fluorocompounds in Human Plasma: Prevalence and Characterisation. In: Biochemistry Involving Carbon-Fluorine Bond, Filler, R., Ed. Am Chem Soc Symp Ser 28:117-134.
- Hall, L.H.; Klipper, R.W.; Mith, F.A.; Morken, D.A.; and Hodge, H.C. (1977): Kinetic Model of Fluoride Metabolism in the Rabbit, Environ Res 13:285-302.[Medline]
[Order article via Infotrieve]
- Hanhijarvi, H.; Penttila, I.; Pekkarinen, A.; and Haku-Linen, A. (1974): The Effect of Age on Free Ionized Plasma Fluoride Concentrations in Patients from Artificially Fluoridated and Non-fluoridated Drinking Water Communities, Proc Finn Dent Soc Suppl 3:25-34.
- Hodge, H.C.; Smith, F.A.; and Gedalia, J. (1970): Excretion of Fluorides. In: Fluorides and Human Health. WHO Monogr Ser No. 59:150-154.
- Jowsey, J.; Riggs, B.L.; and Kelly, P.J. (1979): Fluoride in the Treatment of Osteoporosis. In: Continuing Evaluation of the Use of Fluorides, Johansen, E., Taves, D.R., and Olsen, T.O., Eds. Colorado: AADS Selected Symposium II, Westview Press, pp. 111-124.
- JUst Nielsen, A. (1972): Deposition of Calcium and Phosphorus in Growing Pigs Determined by Balance Experiments and Slaughter Investigations, Acta Agric Scand 22:223-237.
- Kekki, M.; Lampamen, E.; Kauranen, P.; Hoikka, V.; Alhava, E.M.; and Pasternack, A. (1982): The Nonlinear Tissue-Binding Character of Fluoride Kinetics in Normal and Anephric Subjects. Graphical Analysis of Serum Fluoride Data from Man and Rabbit, Nephron 31:129-134.[CrossRef][Medline]
[Order article via Infotrieve]
- Largent, E.J. (1952): Rates of Elimination of Fluoride in the Tissues of Man, Arch Ind Hyg Occup Med 6:37-42.
- McCann, H.G. (1968): Determination of Fluoride in Mineralised Tissues Using the Fluoride Ion Electrode, Arch Oral Biol 13: 475-477.[CrossRef][Medline]
[Order article via Infotrieve]
- Metzler, C.M. (1969): NONLIN Technical Report No. 7292/69/ 7293/005, Kalamazoo: The Upjohn Co.
- Nielsen-Kudsk, F. (1981a): Pharmacokinetic Analysis and Calculations Using a Program for the Minicalculator TI-59, Int J Bio-Medical Computing 12:83-96.[CrossRef]
- Nielsen-Kudsk, F. (1981b): Pharmacokinetic Curve Fitting and Parameter Determination by Non-linear, Iterative Least Squares Regression Analyses Using a Programmed Minicalculator, Int J Bio-Medical Computing 12:503-517.[CrossRef]
- Nielsen-Kudsk, F. (1983a): A Microcomputer Program in Basic for Iterative, Non-linear Data-fitting to Pharmacokinetic Functions, Int J Bio-Medical Computing 14:95-107.[CrossRef]
- Nielsen-Kudsk, F. (1983b): Application of Microcomputers in Analysis and Simulation of Drug Kinetics. A Program Package for Use with the Personal Microcomputer HP-85, Proc of the 1983 Summer Computer Simulation Conference, Vancouver, Canada, pp. 646-651.
- Parfitt, A.M. (1983): The Physiologic and Clinical Significance of Bone Histomorphometric Data. In: Bone Histomorphometry: Techniques and Interpretation, Recker, R.R., Ed. Boca Raton: CRC Press, pp. 143-223.
- Parkins, F.M.; Tinanoff, N.; Mountinho, M.; Anstey, M.B.; and Waziri, M.H. (1974): Relationships of Human Plasma Fluoride and Bone Fluoride to Age, Calcif Tissue Res 16: 335-338.[CrossRef][Medline]
[Order article via Infotrieve]
- Richards, A. (1982): The Pig as an Experimental Model for Studying Fluorosis, Ph.D. dissertation, Royal Dental College, Aarhus, Denmark.
- Richards, A.; Fejerskov, 0.; and Ekstrand, J. (1982): Fluoride Pharmacokinetics in the Domestic Pig, J Dent Res 61: 1099-1102.[Abstract/Free Full Text]
- Richards, A.; Kragstrup, J.; Josephsen, K.; Fejerskov, 0.; and Eklundt Larsen, A. (1983): Experimental Fluorosis in Pigs, J Dent Res 62:492.
- Spencer, G.R.; El-Sayed, F.I.; Kroening, G.H.; Pell, K.L.; Shoup, N.; Adams, D.F.; Franke, M.; and Alexan-Der, J.E. (1971): Effects of Fluoride, Calcium and Phosphorus on Porcine Bone, Am J Vet Res 32:1751-1774.[Medline]
[Order article via Infotrieve]
- Taves, D.R. and Guy, W.S. (1979): Distribution of Fluoride Among Body Compartments. In: Continuing Evaluation of the Use of Fluorides, Johansen, E., Taves, D.R., and Olsen, T.O., Eds. Colorado: AAAS Selected Symposium II, Westview Press, pp. 159-185.
- Teotia, S.P.S. and Teotia, M. (1973): Secondary Hyperparathyroidism in Patients with Endemic Skeletal Fluorosis, Br Med J 1:637-640.[Abstract/Free Full Text]
- Teotia, M.; Teotia, S.P.S.; and Singh, R.K. (1976): Metabolism of Fluoride in Pregnant Women Residing in Endemic Fluorosis Areas, Fluoride 12:58-64.
- Wagner, J.G. (1971): Biopharmaceutics and Relevant Pharmacokinetics. Hamilton, Illinois: Drug Intelligence Publications, Inc.
- Wagner, J.G. (1975): Fundamentals of Clinical Pharmacokinetics. Hamilton, Illinois: Drug Intelligence Publications, Inc.
- Wagner, J.G.; Northam, J.I.; Alway, C.D.; and Carpenter, O.S. (1965): Blood Levels of Drug at the Equilibrium State after Multiple Dosing, Nature 207:1301-1302.[CrossRef][Medline]
[Order article via Infotrieve]
- Waterhouse, C.; Taves, D.; and Munzer, A. (1980): Serum Inorganic Fluoride: Changes Related to Previous Fluoride Intake, Renal Function and Bone Resorption, Clin Science 58:145-152.[Medline]
[Order article via Infotrieve]
Journal of Dental Research, Vol. 64, No. 3,
425-430 (1985)
DOI: 10.1177/00220345850640030601
 CiteULike  Complore  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter What's this?
This article has been cited by other articles:
|
|
|
|
 
A.L.J.J. Bronckers, D.M. Lyaruu, and P.K. DenBesten
The Impact of Fluoride on Ameloblasts and the Mechanisms of Enamel Fluorosis
Journal of Dental Research,
October 1, 2009;
88(10):
877 - 893.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Aoba and O. Fejerskov
DENTAL FLUOROSIS: CHEMISTRY AND BIOLOGY
Critical Reviews in Oral Biology & Medicine,
March 1, 2002;
13(2):
155 - 170.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
O. Fejerskov, M.J. Larsen, A. Richards, and V. Baelum
Dental Tissue Effects of Fluoride
Advances in Dental Research,
June 1, 1994;
8(1):
15 - 31.
[Abstract]
[PDF]
|
|
|
|
|
|
|
A. Richards, G.E. Coote, and E.I.F. Pearce
Proton Probe and Acid Etching for Determining Fluoride Profiles in Porous Porcine Enamel
Journal of Dental Research,
March 1, 1994;
73(3):
644 - 651.
[Abstract]
[PDF]
|
|
|
|
|
|
|
G.M. Whitford, E.D. Biles, and N.L. Birdsong-Whitford
A Comparative Study of Fluoride Pharmacokinetics in Five Species
Journal of Dental Research,
June 1, 1991;
70(6):
948 - 951.
[Abstract]
[PDF]
|
|
|
|
|
|
|
M.J. Larsen, E. Kirkegaard, and S. Poulsen
Patterns of Dental Fluorosis in a European Country in Relation to the Fluoride Concentration of Drinking Water
Journal of Dental Research,
January 1, 1987;
66(1):
10 - 12.
[Abstract]
[PDF]
|
|
|
|
|
|
|
A. Richards, J. Kragstrup, K. Josephsen, and O. Fejerskov
Dental Fluorosis Developed in Post-secretory Enamel
Journal of Dental Research,
December 1, 1986;
65(12):
1406 - 1409.
[Abstract]
[PDF]
|
|
|
|
|
