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Toxicological Assessment of Lidocaine in the Pregnant Rat
L.J. Ramazzotto
Department of Physiology, St. Joseph's Hospital and Medical Center, 703 Main Street, Paterson, New Jersey 07503
F.A. Curro
Department of Pharmacology, St. Joseph's Hospital and Medical Center, 703 Main Street, Paterson, New Jersey 07503
J.A. Paterson
Department of Oral Surgery, Fairleigh Dickinson University, School of Dentistry, 110 Fuller Place, Hackensack, New Jersey 07601, St. Joseph's Hospital and Medical Center, 703 Main Street, Paterson, New Jersey 07503
P. Tanner
Department of Physiology
M. Coleman
Department of Physiology
Teratogenic and toxicological effects of lidocaine administered during pregnancy were evaluated in the Sprague Dawley rat. High doses of lidocaine administered during specific periods of gestation were shown to produce no apparent adverse toxicological or teratogenic effects. Histological, enzymological, and physical features of the fetuses, utilizing conventional toxicological parameters, were all found to be normal following maternal administration of lidocaine. Analysis of these data suggests that the administration of lidocaine during pregnancy had no detectable adverse effects on the fetus.
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Journal of Dental Research, Vol. 64, No. 10,
1214-1217 (1985)
DOI: 10.1177/00220345850640100701
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