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The Effect of Chronic Isoproterenol Administration on the Plasma Membrane of Acinar Cells in Rat Submandibular Gland

Department of Oral Histology

N. Araki

Department of Oral Histology

K. Fukasawa

Department of Oral Biochemistry, Matsumoto Dental College, Shiojiri 399-07, Japan

M. Harada

Department of Oral Biochemistry, Matsumoto Dental College, Shiojiri 399-07, Japan

K. Suzuki

Department of Oral Histology

The effect of chronic administration of isoproterenol on the plasma membrane of acinar cells in the rat submandibular gland was studied by biochemical and immunohistochemical methods, using dipeptidyl peptidase (DPP) IV as a marker enzyme. Chronic isoproterenol treatment led to a marked reduction of DPP IV activity as well as of its immunoreactivity in the gland. Its effect progressively increased with the age of the animals. The present study showed that chronic treatment with isoproterenol caused a qualitative alteration of the plasma membrane of the luminal surface in acinar cells of the rat submandibular gland, and that the effect of the drug on the plasma membrane was dependent on the developmental stage of the acinar cells of the gland.

REFERENCES

• Abe, K. and Dawes, C.: The Secretion of Protein and of Some Electrolytes in Response to a- and β- Adrenergic Agonists by Rat Parotid and Submandibular Salivary Glands Enlarged by Chronic Treatment with Isoproterenol, J Dent Res 59:1081-1089,1980,[Abstract/Free Full Text]
• Barka, T. and Van Der Noen, H.: The Effect of Isoproterenol on Peptide Hydrolase Activities of Submandibular Gland, Lab Invest 20:377-381, 1969.[Medline] [Order article via Infotrieve]
• Barka, T.; Chang, W,W.L.; and Van Der Noen, H.,: Stimulation of DNA Synthesis by Isoproterenol in Rat Submandibular Gland During Postnatal Growth. Cell Tissue Kinet 6:135-146, 1973.[Medline] [Order article via Infotrieve]
• Bressler, R.S.: Fine Structure of the Differentiating Acini in Submandibular Glands of Isoproterenol-treated Rats, Am J Anat 138:431-448, 1973.[CrossRef][Medline] [Order article via Infotrieve]
• Brown-Grant, K.: Enlargement of Salivary Gland in Mice Treated with Isopropylnoradrenaline, Nature 191:1076-1078, 1961.[CrossRef]
• Dreisbach, R.H.: Effect of Isoproterenol on Calcium Metabolism in Rat Salivary Gland, Proc Soc Exp Biol Med 116:953-956, 1964.[CrossRef][Medline] [Order article via Infotrieve]
• Ekfors, T.; Chang, W.W.L.; Bressler, R.S.; and Barka, T.: Isoproterenol Accelerates the Postnatal Differentiation of Rat Submandibular Gland, Dev Biol 29:38-47, 1972.[CrossRef][Medline] [Order article via Infotrieve]
• Fukasawa, K.M.; Fukasawa, K.; Sahara, N.; Harada, M.; Kondo, Y.; andNAGATSU, I.: Immunohistochemical Localization of Dipeptidyl Aminopeptidase IV in Rat Kidney, Liver and Salivary Glands, J Histochem Cytochem 29:337-343, 1981.
• Kato, T.; Nagatsu, T.; Kimura, T.; and Sakakibara, S.: Fluorescence Assay of X-prolyl Dipeptidyl-aminopeptidase Activity with a New Fluorogenic Substrate, Biochem Med 19:351-359, 1978.[CrossRef][Medline] [Order article via Infotrieve]
• Lowry, O.H.; Rosebrough, N.J.; Farr, A.L.; and Randall, R.J.: Protein Measurement with the Folin Phenol Reagent, J Biol Chem 193:265-275, 1951.[Free Full Text]
• McLean, I.W. and Nakane, P.K.: Periodate-lysine-paraformaldehyde Fixative; a New Fixative for Immunoelectron Microscopy, J Histochem Cytochem 22:1077-1083, 1974.[Abstract]
• Meneker, L.; Sheetz, J.H.; Cobb, C.M.; and Navia, J.M.: Gel Electrophoresis of Whole Saliva and Associated Histologic Changes in Submandibular Glands of Isoproterenol-treated Rats, Lab Invest 30:341-349, 1974.[Medline] [Order article via Infotrieve]
• Robinovitch, M.R.; Keller,P.J.; Johnson, D.A.; Iversen, J.M.; and Kauffman, D.L.: Changes in Rat Parotid Salivary Proteins Induced by Chronic Isoproterenol Administration, J Dent Res 56:290-303, 1977.[Abstract/Free Full Text]
• Sahara, N.; Fukasawa, K.M.; Fukasawa, K.; Araki, N.; and Suzuki, K.: Immunohistochemical Localization of Dipeptidyl Aminopeptidase (DAP) IV in the Rat Submandibular Gland During Postnatal Development, Histochemistry 72:229-236, 1981.[CrossRef][Medline] [Order article via Infotrieve]
• Sahara, N. and Suzuki, K.: Ultrastructural Localization of Dipeptidyl Peptidase IV in Rat Salivary Glands by Immunocytochemistry, Cell Tissue Res 235:427-432, 1984.[Medline] [Order article via Infotrieve]
• Schneyer, C.A.: Salivary Gland Change after Isoproterenol-induced Enlargement, Am J Physiol 203:232-236, 1962.[Abstract/Free Full Text]
• Schneyer, C.A. and Shackleford, J.M.: Accelerated Development of Salivary Glands of Early Postnatal Rats Following Isoproterenol, Proc Soc Exp Biol Med 122:320-324, 1963.
• Selye, H.; Veilleux, R.; and Cantin, M.: Excessive Stimulation of Salivary Gland Growth by Isoproterenol, Science 133:44-45,1961.[Abstract/Free Full Text]
• Srinivasan, R.; Chang, W.W.L.; Van Der Noen, H.; and Barka, T.: The Effect of Isoproterenol on the Postnatal Differentiation and Growth of the Rat Submandibular Gland, Anat Rec 177:243-254, 1973.[CrossRef][Medline] [Order article via Infotrieve]
• Sternberger, L.A.: The Unlabeled Enzyme Method. In: Immunocytochemistry, Sternberger, L.A., Ed., New York: John Wiley & Sons, Inc., 1979, pp. 104-169.

Journal of Dental Research, Vol. 63, No. 8, 1028-1031 (1984)
DOI: 10.1177/00220345840630080201


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This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Sahara, N. Articles by Suzuki, K. Search for Related Content PubMed PubMed Citation Articles by Sahara, N. Articles by Suzuki, K. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Social Bookmarking                         What's this?