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Inhibitory Effect of Inositol Phosphates on Parathyroid Hormone-induced Bone Resorption in Organ Cultures

Department of Periodontics

H.W. Kaufman

Department of Oral Biology and Pathology, School of Dental Medicine, State University of New York at Stony Brook, Stony Brook, New York 11794

J.R. Bloom

Department of Periodontics

J. Navon

Department of Periodontics

T.J. Wilkens

Department of Periodontics

R.A. Rifkin

Department of Periodontics

This study investigates the ability of phytic acid, its inositol phosphate derivatives (inositol penta-, tetra-, tri-, di-, and monophosphate), and inorganic phosphate to inhibit parathyroid hormone (PTH)-induced resorption of fetal rat long bones in organ culture. Pregnant rats injected with ⁴⁵Ca on the 18th day of gestation were killed the next day and their fetuses removed. Half of each pair of dissected long bones was incubated in a chemically defined control medium, while the contralateral half was incubated in medium containing PTH or PTH plus the phosphate compound to be tested. 45Ca released into the medium was indicative of the amount of bone resorption. All phosphate compounds tested inhibited resorption. The inositol phosphates should be studied further to assess their suitability as therapeutic agents for treatment of metabolic bone diseases involving increased turnover.

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Journal of Dental Research, Vol. 63, No. 6, 890-893 (1984)
DOI: 10.1177/00220345840630061501


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This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Gomes, B.C. Articles by Rifkin, R.A. Search for Related Content PubMed PubMed Citation Articles by Gomes, B.C. Articles by Rifkin, R.A. Social Bookmarking                         What's this?