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Journal of Dental Research
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Development of New Agents and Techniques for Intravenous Analgesia

P.D. Thut

Department of Pharmacology, Baltimore College of Dental Surgery, Dental School, University of Maryland, 666 West Baltimore Street, Baltimore, Maryland 21201

The search for new anesthetic and analgesic drugs will be aided by analysis of the structures of chemical compounds which variously stimulate the five proposed opioid receptors or the benzodiazepine receptors. The mechanism of interaction between the benzodiazepines, opioids, and the neuroleptics will be further elucidated. These studies will result in discovery of drugs with fewer side-effects and more specific clinical effects.

REFERENCES

  • Kaufman, R.D.: Biophysical Mechanisms of Anesthetic Action: Historical Perspective and Review of Current Concepts, Anesthesiology 46:49-62, 1977.[CrossRef][Medline] [Order article via Infotrieve]
  • Goldstein, A.; Lowney, L.I.; and Pal, B.K.: Stereospecific and Nonspecific Interactions of the Morphine Con-gener Levorphanol in Subcellular Fractions of Mouse Brain, Proc Natl Acad Sci USA 68:1742-1747, 1971.[Abstract/Free Full Text]
  • Pert, C.B. and Snyder, S.H.: Opiate Receptor: Demonstration in Nervous Tissue, Science 179:1011-1014, 1973.[Abstract/Free Full Text]
  • Terenins, L.: Characteristics of the 'Receptor' for Narcotic Analgesics in Synaptic Plasma Membrane Fraction from Rat Brain, Acta Pharmacol Toxicol (Copenh) 33:377-384, 1973.[Medline] [Order article via Infotrieve]
  • Kuhar, M.C.; Pert, C.B.; and Snyder, S.H.: Regional Distribution of Opiate Receptor Binding in Monkey and Human Brain, Nature 245:447-450, 1973.[CrossRef][Medline] [Order article via Infotrieve]
  • Creese, I. and Snyder, S.H.: Receptor Binding and Pharmacological Activity of Opiates in the Guinea-pig Intestine, J Pharmacol Exp Ther 94:205-219, 1975.
  • Goldstein, A. and Cox, B.M.: Opioid Peptides (Endorphins) in Pituitary and Brain, Psychoneuroendocrinology 2:11-16, 1977.[CrossRef][Medline] [Order article via Infotrieve]
  • Snyder, S.H. and Simantov, R.: The Opiate Receptor and Opioid Peptides, J Neurochem 28:13-20, 1977.[CrossRef][Medline] [Order article via Infotrieve]
  • Pert, A. and Yaksh, T.: Sites of Morphine Induced Analgesia in Primate Brain: Relation to Pain Pathways, Brain Res 80:135-140, 1974.[CrossRef][Medline] [Order article via Infotrieve]
  • Hughes, J.: Isolation of an Endogenous Compound from the Brain with Pharmacological Properties Similar to Morphine, Brain Res 881:295-308, 1975.
  • Hughes, J.; Smith, T.W.; Kosterlitz, H.W.; Fother-Gill, L.A.; Morgan, B.A.; and Morris, H.R.: Identification of Two Related Pentapeptides from the Brain with Potent Opiate Agonist Activity, Nature 258:577-579, 1975.[CrossRef][Medline] [Order article via Infotrieve]
  • Simantov, R. and Snyder, S.H.: A Morphine-like Peptide 'Enkephalin' in Mammalian Brain: Isolation, Structure, Elucidation, and Interactions with Opiate Receptor, Life Sci 18: 781-788, 1976.
  • Li, C.H. and Chung, D.: Isolation and Structure of an Untriakontapeptide with Opiate Activity from Camel Pituitary Glands, Proc Natl Acad Sci USA 73:1145-1148, 1976.[Abstract/Free Full Text]
  • Guillemin, R.; Vargo, T.; Rossier, J.; Minick, S.; Ling, N.; Rivier, C.; Vale, W.; and Bloom, F.: Beta-Endorphine and Adrenocorticotropin are Secreted Concomitantly by the Pituitary Gland, Science 197:1367-1369, 1977.[Abstract/Free Full Text]
  • Lazarus, L.H.; Ling, N.; and Guillemin, R.: Betalipotropin as a Prohormone for the Morphinomimetic Peptides and Enkephalins, Proc Natl Acad Sci USA 73:2156-2159, 1976.[Abstract/Free Full Text]
  • Guillemin, R.; Ling, N.; and Burgus, R.: Endorphins: Peptides of Hypothalamic and Neurohypophyseal Origin. Isolation and Molecular Structure of Alpha -endorphin, CR Acad Sci (D) (Paris) 28:783-785, 1976.
  • Belluzzi, J.D.; Grant, N.; Garsky, V.; Sarantakes, D.; Wise, C.D.; and Stein, L.: Analgesia Induced in vivo by Central Administration of Enkephalin in Rat, Nature 260:625-626, 1976.[CrossRef][Medline] [Order article via Infotrieve]
  • Hambrook, J.; Morgan, B.; Race, M.; and Smith, C.L.: Mode of Deactivation of the Enkephalins by Rat and Human Plasma and Rat Brain Homogenates, Nature 262:782-783, 1976.[CrossRef][Medline] [Order article via Infotrieve]
  • Snyder, S.H.: Brain Peptides as Neurotransmitters, Science 209:976-983,1980.[Abstract/Free Full Text]
  • Coy, D.; Kastin, A.; Schally, A.; Morin, 0.; Caron, N.; Labrie, F.; Walker, J.; Fertel, R.; Berston, G.; and Sandman, C.: Synthesis and Opioid Activities of Stereoisomers and Other D-amino Acid Analogs of Methionineenkephaline, Biochem Biophys Res Commun 73:632-638, 1976.[Medline] [Order article via Infotrieve]
  • Martin, W.R.; Eades, C.G.; Thompson, J.A.; Huppler, R.E.; and Gilbert, P.E.: The Effects of Morphine- and Nalorphine-like Drugs in the Non-dependent and Morphine-dependent Chronic Spinal Dog, J Pharmacol Exp Ther 197: 517-532, 1976.[Abstract/Free Full Text]
  • Lord, J.A.H.; Waterfield, A.A.; Hughes, J.; and Kosterlitz, H.W.: Endogenous Opioid Peptides: Multiple Agonists and Receptors, Nature 267:495-499, 1977.[CrossRef][Medline] [Order article via Infotrieve]
  • Tallarida, R.J.: The Use of Drug-receptor Affinity Measures in the Differentiation of Receptors, Fed Proc 41:2323-2327,1982.[Medline] [Order article via Infotrieve]
  • Krimmer, E.C. and Barry, H.: Measuring Naloxone Antagonism of Discriminative Opioid Stimulus, Fed Proc 41:2319-2322, 1982.[Medline] [Order article via Infotrieve]
  • Holtzman, S.G.: Stimulus Properties of Opioids with Mixed Agonist and Antagonist Activity, Fed Proc 41:2328-2332, 1982.[Medline] [Order article via Infotrieve]
  • Young, A.M. and Woods, J.H.: Limitations on the Antagonistic Actions of Opioid Antagonists, Fed Proc 41:2333-2338, 1982.[Medline] [Order article via Infotrieve]
  • Enna, S.J. and Defrance, J.F.: Glycine, GABA and Benzodiazepine Receptors. In: Neurotransmitter Receptors: Part 1, Amino Acids, Peptides and Benzodiazepines, Enna, S.J. and Yamamura, H.I., Eds., New York: Chapman and Hall, 1980, pp. 41-70.
  • Cheng, S.C. and Brunner, E.: Two Neurotransmitters in Brain Slices. In: Molecular Mechanisms of Anesthesia, Fink, B.R., Ed., New York: Raven Press, 1975, pp. 509-518.
  • Mohler, H. and Okada, T.: Benzodiazepine Receptor: Demonstration in the Central Nervous System, Science 198: 849-851, 1977.[Abstract/Free Full Text]
  • Skolnick, P.; Syapin, P.J.; and Paugh, B.A.: Inosine, an Endogenous Ligand of the Brain Benzodiazepine Receptor, Antagonizes Pentylenetetrazole-evoked Seizures , Proc Natl Acad Sci USA 76:1515-1518, 1979.[Abstract/Free Full Text]
  • Aprison, M.H. and Werman, R.: The Distribution of Glycine in Cat Spinal Cord and Roots, Life Sci 4:2075-2083, 1965.[CrossRef][Medline] [Order article via Infotrieve]
  • Snyder, S.H.; Enna, S.J.; and Young, A.B.: Brain Mechanisms Associated with Therapeutic Actions of Benzodiazepines: Focus on Neurotransmitters, Am J Psychiatry 134:662-664, 1977.[Abstract/Free Full Text]
  • Kolata, G.: Research News - New Valiums and Anti-valiums on the Horizon, Science 216:604-605, 1982.[Free Full Text]
  • Creese, I.; Burt, D.R.; and Snyder, S.H.: Biochemical Action of Neuroleptic Drugs: Focus on Dopamine. In: Handbook of Psychopharmacology, Vol. 10, Iversen, L.L., Iversen, S.D., and Snyder, S.H., Eds., New York: Plenum Press, 1978, pp. 37-89.

Journal of Dental Research, Vol. 63, No. 6, 834-837 (1984)
DOI: 10.1177/00220345840630060301


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This Article
Right arrow Abstract Freely available
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
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Right arrow Email this article to a friend
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Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Thut, P.D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Thut, P.D.
Social Bookmarking
 Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?