This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Husband, A.J. Articles by Sheldrake, R.F. Search for Related Content PubMed PubMed Citation Articles by Husband, A.J. Articles by Sheldrake, R.F. Social Bookmarking                         What's this?

Induction and Delivery of Mucosal Immune Responses

Faculty of Medicine, The University of Newcastle, New South Wales 2308, Australia

M.L. Dunkley

Faculty of Medicine, The University of Newcastle, New South Wales 2308, Australia

R. Scicchitano

Faculty of Medicine, The University of Newcastle, New South Wales 2308, Australia

R.F. Sheldrake

Faculty of Medicine, The University of Newcastle, New South Wales 2308, Australia

The oral cavity is relatively deficient in lymphoid tissue capable of directing the inductive and effector events required for effective mucosal IgA responses to local antigen. Recent evidence regarding a common mucosal immune system has raised new possibilities in immunization of mucosal surfaces. This review describes the role of the intestine in contributing to responses at distant mucosal sites and in particular emphasizes the immune potential of the intestine in determining the success of immunization strategies to control dental caries.

REFERENCES

• Guggenheim, B.; Mühlemann, R.; Regolati, B.; and Schmid, R.: The Effect of Immunisation against Streptococci or Glucosyl-transferase on Plaque Formation and Dental Caries in Rats. In: Dental Plaque, W.D. McHugh, Ed., London: Thomson, 1970, pp. 287-296.
• Tanzer, J.M.; Hageage, G.J.; and Larson, R.H.: Variable Experience in Immunization of Rats Against Streptococcus mutans-associated Dental Caries, Arch Oral Biol 18: 1425-1439,1973.[CrossRef][Medline] [Order article via Infotrieve]
• Tomasi, T.B. and Bienenstock, J.: Secretory Immunoglobulins, Adv Immunol 9:1-96, 1968.[Medline] [Order article via Infotrieve]
• Bienenstock, J.; Befus, A.K.; and McDermott, M.: Mucosal Immunity, Monogr Allergy 16:1-18, 1980.[Medline] [Order article via Infotrieve]
• Evans, R.T.; Emmings, F.G.; and Genco, R.J.: Prevention of Streptococcus mutans Infection of Tooth Surfaces by Salivary Antibody in Irus Monkeys (Macaca fascicularis), Infect Immun 12:293-302, 1975.[Abstract/Free Full Text]
• Taubman, M.A. and Smith, D.J.: Effects of Local Immunisation with Streptococcus mutans on Induction of Salivary Immunoglobulin A Antibody and Experimental Dental Caries in Rats, Infect Immun 9:1079-1091, 1974.[Abstract/Free Full Text]
• McGhee, J.R.; Michalek, S.M.; Webb, J.; Navia, J.M.; Rhaman, A.F.R.; and Legler, D.W.: Effective Immunity to Dental Caries: Protection of Gnotobiotic Rats by Local Immunization with Streptococcus mutans, J Immunol 114: 300-305, 1975.[Abstract/Free Full Text]
• Brandtzaeg, P.; Fjellanger, I.; and Gjeruldsen, S.T.: Immunoglobulin M: Local Synthesis and Selective Secretion in Patients with Immunoglobulin A Deficiency, Science 160:789-791, 1968.[Abstract/Free Full Text]
• Chodirker, W.B. and Tomasi, T.B.: Gammaglobulins: Quantitative Relationships in Human Serum and Non-vascular Fluids, Science (NY) 142:1080-1081, 1963.
• Brandtzaeg, P.; Fjellanger, I.; and Gjeruldsen, S.T.: Adsorption of Immunoglobulin A onto Oral Bacteria in vivo, J Bacteriol 96:242-249, 1968.[Abstract/Free Full Text]
• Williams, R.C. and Gibbons, R.J.: Inhibition of Bacterial Adherence by Secretory Immunoglobulin A: A Mechanism of Antigen Disposal, Science 177:697-699, 1972.[Abstract/Free Full Text]
• Gibbons, R.J. and Van Houte, J.: Bacteriology of Dental Caries. In: Textbook of Oral Biology, J.H. Shaw, E.A. Sweeney, C.C. Capuccino, and S.M. Miller, Eds., Philadelphia: W.B. Saunders Co., 1978, pp. 975-991.
• Genco, R.J.; Evans, R.T.; and Taubman, M.A.: Secretory Antibodies to Streptococcus mutans: Significance in Inhibition of Adherence. In: The Immunoglobulin A System, J. Mestecky and A.R. Lawton, Eds., New York: Plenum Publishing Corp., 1974, pp. 327-336.
• Ebersole, J.L.; Taubman, M.A.; and Smith, D.J.: Effect of Neonatal Thymectomy on Dental Caries in Rats, Infect Immun 38:1130-1136, 1982.[Abstract/Free Full Text]
• Abney, E.R.; Copper, M.D.; Kearney, J.F.; Lawton, A.R.; and Parkhouse, R.M.E.: Sequential Expression of Immunoglobulin on Developing Mouse B Lymphocytes: A Systematic Survey that Suggests a Model for the Generation of Immunoglobulin Isotype Diversity, J Immunol 120:2041-2049, 1978.[Abstract/Free Full Text]
• Kawanishi, H.; Saltzman, L.E.; and Strober, W.: Characterisation and Regulatory Function of Murine Con A-induced, Cloned T Cells Obtained from Peyer's Patches and Spleen: Mechanisms Regulating Isotype-specific Immunoglobulin Production by Peyer's Patch B Cells, J Immunol 129: 475-483, 1982.[Medline] [Order article via Infotrieve]
• Clough, J.D.; Mims, L.H.; and Strober, W.: Deficient IgA Antibody Responses to Arsanilic Acid Bovine Serum Albumin (BSA) in Neonatally Thymectomized Rabbits, J Immunol 106: 1624-1629, 1971.[Abstract/Free Full Text]
• Crewther, P. and Warner, N.L.: Serum Immunoglobulins and Antibodies in Congenitally Athymic (Nude) Mice, Aust J Exp Biol Med Sci 50:625-635, 1972.[CrossRef][Medline] [Order article via Infotrieve]
• Ebersole, J.L.; Taubman, M.A.; Smith, D.J.; Genco, R.J.; and Frey, D.E.: Human Immune Responses to Oral
• Micro-organisms. I. Association of Localized Juvenile Periodontitis (LJP) with Serum Antibody Responses to Actinobacillus actinomycetemcomitans, Clin Exp Immunol 47:43-52, 1982.[Medline] [Order article via Infotrieve]
• Ebersole, J.L.; Taubman, M.A.; and Smith, D.J.: Thymic Control of Secretory Antibody Responses in the Rat, J Immunol 123:19-24, 1979.[Abstract/Free Full Text]
• Ebersole, J.L.; Taubman, M.A.; and Smith, D.J.: The Effect of Neonatal Thymectomy on the Level of Salivary and Serum Immunoglobulins in Rats, Immunology 36:649-657, 1979.[Medline] [Order article via Infotrieve]
• McDermott, M.R.; Befus, A.D.; and Bienenstock, J.: The Structural Basis for Immunity in the Respiratory Tract, Int Rev Exp Pathol 23:47-112, 1982.[Medline] [Order article via Infotrieve]
• Williams, D.M. and Rowland, A.C.: The Palatine Tonsils of the Pig - An Afferent Route to the Lymphoid Tissue, J Anat 113:131-137, 1972.[Medline] [Order article via Infotrieve]
• Curran, R.C. and Jones, E.L.: The Lymphoid Follicles of the Human Palatine Tonsils, Clin Exp Immunol 31:251-259, 1978.[Medline] [Order article via Infotrieve]
• Butcher, E.C.; Scollay, R.G.; and Weissman, J.L.: Organ Specificity of Lymphocyte Migration: Mediation by Highly Selective Lymphocyte Interaction with Organ-specific Determinants on High Endothelial Venules, Eur J Immunol 10: 556-561, 1980.[Medline] [Order article via Infotrieve]
• Owen, R.L. and Nemanic, P.: Antigen Processing Structures of the Mammalian Intestinal Tract: An SEM Study of Lymphoepithelial Organs. In: Scanning Electron Microscopy, R.P. Becker and 0. Johari, Eds., Illinois: A.M.F. O'Hare, IL, 1978, pp. 367-378.
• Crabbé, P.A. and Heremans, J.F.: Distribution in Human Nasopharyngeal Tonsils of Plasma Cells Containing Different Types of Immunoglobulin Polypeptides, Lab Invest 16:112-123,1967.[Medline] [Order article via Infotrieve]
• Curran, R.C. and Jones, E.L.: Immunoglobulin-containing Cells in Human Tonsils as Demonstrated by Immunohistochemistry, Clin Exp Immunol 28:105-115, 1977.
• Brandtzaeg, P.; Surjan, L.; and Berdal, P.: Immunoglobulin Systems of Human Tonsils. I. Control Subjects of Various Ages: Identification of Ig-producing Cells, Tonsillar Morphometry and Serum Ig Concentrations, Clin Exp Immunol 31:367-381,1978.
• Brandtzaeg, P.; Gjeruldsen, S.T.; Korsrud, F.; Baklien, K.; Berdal, P.; and Ek, J.: The Human Secretory Immune System Shows Striking Heterogeneity with Regard to Involvement of J-chain Positive IgD Immunocytes, J Immunol 122:503-510, 1979.[Abstract/Free Full Text]
• Platts-Mills, T. and Ishizaka, K.: IgG and IgA Diphtheria Anti-toxin Responses from Human Tonsil Lymphocytes, J Immunol 114:1058-1064, 1975.[Abstract/Free Full Text]
• Smith, R.S.; Sherman, N.A.; and Newcomb, R.W.: Synthesis and Secretion of Immunoglobulins, Including IgA, by Human Tonsil and Adenoid Tissue Cultured in vitro, Int Arch Allergy Appl Immun 46:785-801, 1974.[Medline] [Order article via Infotrieve]
• Matthews, J.B. and Basu, M.K.: Oral Tonsils: An Immunoperoxidase Study, Int Arch Allergy Appl Immun 69:21-25, 1982.[Medline] [Order article via Infotrieve]
• Tomasi, T.B. and Grey, H.M.: Structure and Function of Immunoglobulin A, Prog Allergy 16:81-213, 1972.[Medline] [Order article via Infotrieve]
• Tourville, D.R.; Adler, R.H.; Bienenstock, J.; and Tomasi, T.B.: The Human Secretory Immunoglobulin System: Immunohistological Localization of A, Secretory "Piece", and Lactoferrin in Normal Human Tissues, J Exp Med 129:411-429, 1969.
• Kraus, F.W. and Mestecky, J.: Immunohistochemical Localization of Amylase, Lysozyme and Immunoglobulins in the Human Parotid Gland, Arch Oral Biol 16:781-789, 1971.[CrossRef][Medline] [Order article via Infotrieve]
• Mogi, G.: Secretory Immunoglobulin A in Oral and Respiratory Passages in Man, Ann Otol Rhinol Laryngol 84 (Suppl. 20, No. 3, Part 2):1-23, 1975.[Medline] [Order article via Infotrieve]
• Korsrud, F.R. and Brandtzaeg, P.: Quantitative Immunohistochemistry of Immunoglobulin- and J-chain-producing Cells in Human Parotid and Submandibular Salivary Glands, Immunology 39:129-140, 1980.[Medline] [Order article via Infotrieve]
• Husband, A.J.; Monié, H.J.; and Gowans, J.L.: The Natural History of the Cells Producing IgA in the Gut, Ciba Found Symp 46:29-54, 1977.[Medline] [Order article via Infotrieve]
• McDermott, M.R. and Bienenstock, J.: Evidence for a Common Mucosal Immunologic System. I. Migration of B Immunoblasts into Intestinal, Respiratory, and Genital Tissues, J Immunol 122:1892-1898, 1979.
• McWilliams, M.; Phillips-Quagliata, J.M.; and Lamm, M.E.: Mesenteric Lymph Node B Lymphoblasts which Home to the Small Intestine are Pre-committed to IgA Synthesis, J Exp Med 145:866-875, 1977.[Abstract/Free Full Text]
• Roux, M.E.; McWilliams, M.; Phillips-Quagliata, J.M.; Weisz-Carrington, P.; and Lamm, M.E.: Origin of IgA-secreting Plasma Cells in the Mammary Gland, J Exp Med 146:1311-1322,1977.[Abstract/Free Full Text]
• Jackson, D.E.; Lally, E.T.; Nakamura, M.C.; and Montgomery, P.C.: Migration of IgA-bearing Lymphocytes into Salivary Glands, Cell Immunol 63:203-209, 1981.[CrossRef][Medline] [Order article via Infotrieve]
• Ferguson, A. and McDonald, T.T.: Effects of Local Delayed Hypersensitivity on the Small Intestine, Ciba Found Symp 46:305-319, 1977.[Medline] [Order article via Infotrieve]
• Guy-Grand, D.; Griscelli, C.; and Vassalli, P.: The Gut-associated Lymphoid System: Nature and Properties of the Large Dividing Cells, Eur J Immunol 4:435-443, 1974.[Medline] [Order article via Infotrieve]
• Gowans, J.L. and Knight, E.J.: The Route of Re-circulation of Lymphocytes in the Rat, Proc R Soc (B) 159:257-282, 1964.[Medline] [Order article via Infotrieve]
• Husband, A.J. and Gowans, J.L.: The Origin and Antigen-dependent Distribution of IgA-containing Cells in the Intestine, J Exp Med 148:1146-1160, 1978.[Abstract/Free Full Text]
• Scicchitano, R.; Husband, A.J.; and Clancy, R.L.: Contribution of Gut Immunisation to the Local Immune Response in the Respiratory Tract of Sheep, Immunology (submitted for publication), 1984.
• Beh, K.J.; Husband, A.J.; and Lascelles, A.K.: Intestinal Response of Sheep to Intraperitoneal Immunisation, Immunology 37:385-388, 1979.[Medline] [Order article via Infotrieve]
• Husband, A.J.; Cripps, A.W.; and Clancy, R.L.: Generation and Migration Patterns of Intestinal T- and B-lymphocytes in Response to Local Antigen, Ann NY Acad Sci 409:828, 1983.[CrossRef]
• Husband, A.J.; Dunkley, M.L.; Cripps, A.W.; and Clancy, R.L.: Distribution of Antigen Reactive T Lymphocytes Following Intestinal Administration of Alloantigens, J Immunol (submitted for publication), 1984.
• Vaerman, J.-P.: Studies on IgA Immunoglobulins in Man and Animals. Thesis, Universite Catholique de Louvain, Sintal-Louvain, 1970.
• Halsey, J.F.; Johnson, B.H.; and Cebra, J.J.: Transport of Immunoglobulins from Serum into Colostrum, J Exp Med 151:767-772, 1980.[Abstract/Free Full Text]
• Halsey, J.F.; Mitchell, C.; Meyer, R.; and Cebra, J.J.: Metabolism of Immunoglobulin A in Lactating Mice: Origins of Immunoglobulin A in Milk, Eur J Immunol 12:107-112,1982.[Medline] [Order article via Infotrieve]
• Dahlgren, U.; Ahlstedt, S.; Hedman, L.; Wads-Worth, C.; and Hanson, L.A.: Dimeric IgA in the Rat is Transferred from Serum into Bile but not into Milk, Scand J Immunol 14:95-98, 1981.[CrossRef][Medline] [Order article via Infotrieve]
• Russell, M.W.; Brown, T.A.; and Mestecky, J.: Preferential Transport of IgA and IgA-immune Complexes to Bile Compared with Other External Secretions, Mol Immunol 19: 677-682,1982.[CrossRef][Medline] [Order article via Infotrieve]
• Sheldrake, R.F.; Husband, A.J.; Watson, D.L.; and Cripps, A.W.: Selective Transport of Serum Derived IgA into Mucosal Secretions, J Immunol (in press), 1984.
• Lascelles, A.K. and McDowell, G.H.: Localized Humoral Immunity with Particular Reference to Ruminants, Transplant Rev 19:170-208, 1974.[Medline] [Order article via Infotrieve]
• Lehner, T.; Challacombe, S.J.; and Caldwell, J.: Oral Immunisation with Streptococcus mutans in Rhesus Monkeys and the Development of Immune Responses and Dental Caries, Immunology 41:857-864, 1980.[Medline] [Order article via Infotrieve]
• Russell, M.W.; Challacombe, S.J.; and Lehner, T.: Specificity of Antibodies Induced by Streptococcus mutans During Immunization against Dental Caries, Immunology 40: 97-106, 1980.[Medline] [Order article via Infotrieve]
• Clancy, R.L.; Cripps, A.W.; Husband, A.J.; and Buck-Ley, D.: Specific Immune Response in the Respiratory Tract after Administration of an Oral Polyvalent Bacterial Vaccine, Infect Immun 39:491-496, 1983.[Abstract/Free Full Text]
• Michalek, S.M.; McGhee, J.R.; and Babb, J.L.: Effective Immunity to Dental Caries: Dose-dependent Studies of Secretory Immunity by Oral Administration of Streptococcus mutans to Rats, Infect Immun 19:217-224, 1978.[Abstract/Free Full Text]
• Morisaki, I.; Michalek, S.M.; Harmon, C.C.; Torii, M.; Hamada, S.; and McGhee, J.R.: Effective Immunity to Dental Caries: Enhancement of Salivary Anti-Streptococcus mutans Antibody Responses with Oral Adjuvants, Infect Immun 40: 577-591, 1983.[Abstract/Free Full Text]

Journal of Dental Research, Vol. 63, No. 3, 465-469 (1984)
DOI: 10.1177/00220345840630032001


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Husband, A.J. Articles by Sheldrake, R.F. Search for Related Content PubMed PubMed Citation Articles by Husband, A.J. Articles by Sheldrake, R.F. Social Bookmarking                         What's this?