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Neutrophil Receptor Modulation in the Pathogenesis of Periodontal Diseases

Department of Periodontology and Oral Biology, Emory University School of Dentistry, Atlanta, Georgia 30322

The role of the neutrophil as a primary protective cell in the pathogenesis of periodontal disease has been well established. In this paper, the role of receptor modulation on the neutrophil surface is discussed as a possible mechanism for neutrophil functional abnormalities. Using localized juvenile periodontitis (LJP) as a model, the direct inhibition of neutrophils by bacterial products is discussed as a possible mechanism for local neutrophil dysfunction. In both disease processes, neutrophil receptor modulation plays a central role.

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Journal of Dental Research, Vol. 63, No. 3, 452-454 (1984)
DOI: 10.1177/00220345840630031701


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