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An Incisor Plaque Model in Rats

Indiana University School of Dentistry, Oral Health Research Institute, 415 Lansing Street, Indianapolis, Indiana 46202

J.L. McDonald

Indiana University School of Dentistry, Oral Health Research Institute, 415 Lansing Street, Indianapolis, Indiana 46202

G.K. Stookey

Indiana University School of Dentistry, Oral Health Research Institute, 415 Lansing Street, Indianapolis, Indiana 46202

K.K. Park

Indiana University School of Dentistry, Oral Health Research Institute, 415 Lansing Street, Indianapolis, Indiana 46202

An in vivo model for studying plaque accumulation in rats has been described. This model investigates plaque formation on the mandibular incisors in animals which have been found to be rapid plaque-formers during a pre-test period. The accessibility of these tooth surfaces permits the removal of plaque prior to initiation of tests, the use of test groups balanced on the basis of plaque-forming potential, and interitn assessments of plaque formation throughout the test period, In addition, baseline plaque scores of near zero can be attained, thereby permitting investigations of the impact of experimental measures on plaque formation. Moreover, the model permits intermittent plaque assessments throughout the test period, This model was found to have adequate sensitivity to distinguish effects between antimicrobial agents known to differ in their clinical activity and to detect differences between varying concentrations of the same agent.

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Journal of Dental Research, Vol. 63, No. 1, 32-36 (1984)
DOI: 10.1177/00220345840630010701


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This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Schemehorn, B.R. Articles by Park, K.K. Search for Related Content PubMed PubMed Citation Articles by Schemehorn, B.R. Articles by Park, K.K. Social Bookmarking                         What's this?