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Basic Biological Sciences The Effects of Fatty Acids and Their Monoesters on the Metabolic Activity of Dental Plaque

Department of Biochemistry (Oral Biology), University of Bristol, Bristol, BS8 ITD, United Kingdom

We examined the effects of the saturated series of fatty acids and their esters on plaque bacterial metabolism. Fatty acids with a chain length of 8-15 carbons inhibited Streptococcus mutans and dental plaque in vitro. The glycerol monoesters with a fatty acid chain of 10-14 carbons were inhibitory to a similar extent. The glycolipid (sucrose monolaurate) reduced plaque bacterial glycolysis and sucrose oxidation in a non-competitive manner but stimulated sucrose incorporation at low sucrose concentrations. The relationship between surface activity and inhibition is discussed, since this may help to explain the anti-caries effects of these compounds.

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Journal of Dental Research, Vol. 63, No. 1, 2-5 (1984)
DOI: 10.1177/00220345840630010301


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This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Hayes, M.L. Search for Related Content PubMed PubMed Citation Articles by Hayes, M.L. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Hazardous Substances DB GLUCOSE SUCROSE Social Bookmarking                         What's this?