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Journal of Dental Research
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The Role of Cyclic AMP, Calcium, and Prostaglandins in the Induction of Osteoclastic Bone Resorption Associated with Experimental Tooth Movement

K. Yamasaki

Department of Orthodontics, Showa University Dental Hospital, Ohta-ku, Kitasenzoku 2-1-1, Tokyo 145, Japan

Administration of imidazole and verapamil inhibited the appearance of osteoclasts and bone resorption induced by experimental tooth movement in rats. On the other hand, administration of theophylline and ouabain enhanced the appearance of osteoclasts. A mixed solution of DB cyclic AMP and A-23187 injected in gingiva near the orthodontically-treated teeth caused enhancement of the appearance of osteoclasts and bone resorption.

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Journal of Dental Research, Vol. 62, No. 8, 877-881 (1983)
DOI: 10.1177/00220345830620080501
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