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Nuclear Magnetic Resonance Spectroscopic Studies of the Interaction of Phospholipids with Stabilizing Lysosome Agents

School of Dentistry, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113

Y. Kadoma

Institute for Medical and Dental Engineering, Tokyo Medical and Dental University, 2-3-10 Surugadai, Kanda, Chiyoda-ku, Tokyo 101, Japan

E. Masuhara

Institute for Medical and Dental Engineering, Tokyo Medical and Dental University, 2-3-10 Surugadai, Kanda, Chiyoda-ku, Tokyo 101, Japan

The interaction between phospholipids and stabilizing lysosome agents such as acetylsalicylic acid (ASA), colchicine (CC), prednisolone (PD), etc., was studied using NMR spectroscopy. The peak intensity of protons arising from these compounds was reduced in liposomes containing lecithin and various agents with a molar ratio of 1:1 in D₂O. The reduced percentage of protons in the agents differed due to their molecular structures: ASA was about 20%, CC about 30%, and PD about 100%.

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Journal of Dental Research, Vol. 62, No. 7, 803-805 (1983)
DOI: 10.1177/00220345830620070501


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This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Fujisawa, S. Articles by Masuhara, E. Search for Related Content PubMed PubMed Citation Articles by Fujisawa, S. Articles by Masuhara, E. Social Bookmarking                         What's this?