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Effect of Dichloromethylene Diphosphonate on Fluoride Balance in Healthy Men

Department of Oral Medicine and Hospital Dentistry, School of Dentistry, University of California, San Francisco, California 94143

L. Leybin

Department of Oral Medicine and Hospital Dentistry, School of Dentistry, University of California, San Francisco, California 94143

J.T. McDonald

U.S. Public Health Service Hospital, San Francisco, California 94118

V.S. Schneider

U.S. Public Health Service Hospital, San Francisco, California 94118

E. Newbrun

Department of Oral Medicine and Hospital Dentistry, School of Dentistry, University of California, San Francisco, California 94143

H.C. Hodge

Department of Oral Medicine and Hospital Dentistry, School of Dentistry, University of California, San Francisco, California 94143, Department of Pharmacology, School of Medicine, UCSF, Department of Community and Environmental Medicine, California College of Medicine, University of California, Irvine, California 92717

Healthy men with a daily intake of 0.37 mg fluoride were given dichloromethylene diphosphonate (Cl ₂MDP) or a placebo during a period of ambulation followed by bed rest. In both groups, serum ionic fluoride was unchanged, and fluoride balances were negative, but Cl₂MDP significantly reduced loss of fluoride in the treated groups.

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Journal of Dental Research, Vol. 62, No. 5, 559-561 (1983)
DOI: 10.1177/00220345830620051001


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This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Maheshwari, U.R. Articles by Hodge, H.C. Search for Related Content PubMed PubMed Citation Articles by Maheshwari, U.R. Articles by Hodge, H.C. Social Bookmarking                         What's this?