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In vitro Caries-like Lesion Formation in F-containing Tooth Enamel
R.Z. LeGeros
New York University Dental Center, 354 East 24th St., New York, New York 10010
L.M. Silverstone
University of Colorado Dental School, Denver, Colorado 80262
G. Daculsi
Université de Nantes, Place Alexis-Ricordeau, 44000 Nantes, France
L.M. Kerebel
Université de Nantes, Place Alexis-Ricordeau, 44000 Nantes, France
In vitro caries-like lesion formation in F-containing tooth enamel (shark) showed a lower depth of penetration compared to that in human enamel (42 vs. 100%). After longer periods of exposure, the depth of penetration in shark enamel is only 33% relative to that in human enamel. The extent of dissolution in acetate buffer for powdered human enamel and for synthetic F-free calcium-carbonated-apatites was greater than for powdered shark enamel and for synthetic F-containing apatites.
These results suggest that the cariostatic action of fluoride may be explained in terms of a combination of two effects: (a) the stabilizing effect against acid dissolution (caries) when fluoride is incorporated in the tooth mineral (apatite), and (b) a greater degree of remineralization (repair) in the presence of F solution.
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Journal of Dental Research, Vol. 62, No. 2,
138-144 (1983)
DOI: 10.1177/00220345830620021101
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