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Journal of Dental Research
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A Mouthrinse which Optimizes in vivo Generation of Hypothiocyanite

B. Mansson-Rahemtulla

Department of Pediatric Dentistry, School of Dentistry

K.M. Pruitt

Department of Biochemistry, University of Alabama in Birmingham, Birmingham, Alabama 35294

J. Tenovuo

Institute of Dentistry, University of Turku, Turku 52, Finland

T.M. Le

Department of Biochemistry, University of Alabama in Birmingham, Birmingham, Alabama 35294

We report here the properties of a mouthrinse which enhances one of the natural defense factors in human saliva, the salivary peroxidase system. Concentrations of the antimicrobial agent, the hypothiocyanite (OSCN-) ion, can be increased in vivo to bacteriostatic levels by use of a mouthrinse which is 4 mM (0.014%) in hydrogen peroxide and I mM (0.0097%) in potassium thiocyanate at pH 5.5. The volume of the rinse, the H2O2 concentrations, and the pH were shown to be determinants of the concentration of OSCN- generated by the rinse.

REFERENCES

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  • Pruitt, K.M.; Tenovuo, J.; Fleming, W.; and Adam-Son, M.: Limiting Factors for the Generation of Hypothiocyanite Ion, an Antimicrobial Agent, in Human Saliva, Caries Res 16:315-323, 1982.[Medline] [Order article via Infotrieve]
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Journal of Dental Research, Vol. 62, No. 10, 1062-1066 (1983)
DOI: 10.1177/00220345830620101101
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[Abstract] [Full Text] [PDF]

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