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Target Cells for 1,25-Dihydroxyvitamin D3 in Developing Rat Incisor Teeth

School of Dentistry, University of North Carolina, Chapel Hill, North Carolina 27514

W.E. Stumpf

Departments of Anatomy and Pharmacology, University of North Carolina, Chapel Hill, North Carolina 27514

S.A. Clark

Departments of Anatomy and Pharmacology, University of North Carolina, Chapel Hill, North Carolina 27514

M. Sar

Departments of Anatomy and Pharmacology, University of North Carolina, Chapel Hill, North Carolina 27514

H.F. DeLuca

Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706

The concentration of radioactivity is observed in the nuclei of pulpal cells of maxillary and mandibular incisors of 20-day-old fetal rats, following injection of [³H]-1,25 (OH) ₂ vitamin D₃. Cells in the odontoblast and ameloblast layers are essentially free of nuclear labeling. The radioactively labeled pulpal cells exist throughout the length of the incisors with the exception of the progenitor areas. The results indicate the presence of receptors for 1,25 (OH)₂ vitamin D₃ in pulpal cells, and suggest the effects of the hormone on these cells.

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Journal of Dental Research, Vol. 62, No. 1, 58-59 (1983)
DOI: 10.1177/00220345830620011301


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