This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Tsao, T.-F. Articles by Horikoshi, A.K. Search for Related Content PubMed PubMed Citation Articles by Tsao, T.-F. Articles by Horikoshi, A.K. Social Bookmarking                         What's this?

Effect of Chinese and Western Antimicrobial Agents on Selected Oral Bacteria

UCLA School of Dentistry, Section of Periodontics, Los Angeles, California 90024

M.G. Newman

UCLA School of Dentistry, Section of Periodontics, Los Angeles, California 90024

Y.-Y. Kwok

Wadsworth Veterans Administration Hospital, Los Angeles, California 90073

A.K. Horikoshi

UCLA School of Dentistry, Section of Periodontics, Los Angeles, California 90024

The susceptibility of selected oral bacteria, including suspected periodontopathogens, to a commonly employed Chinese herbal medicine Huang-chin (HC, Scutellaria baicalensis) was tested in vitro. The minimum inhibitory concentration (MIC) and minimum bactericidal concentrations (MBC) were determined. HC was also compared with tetracycline, alexidine, and stannous fluoride. HCdecoction, ata concentration of 2%, was bacteriostatic in eight of 11 bacteria tested, but a concentration of 3.13% or greater was required for bactericidal effect. Among the tested bacteria, Bacteroides melaninogenicus ss intermedius was the most sensitive (MIC = 1.57%, MBC = 2%); Actinomyces viscosus was the least sensitive (MIC = 6.25%, MBC 12.5%). Tetracycline, alexidine, and SnF2 were bactericidal in vitro in all bacteria tested at concentrations lower than those used clinically.

REFERENCES

• Loesche, W.J.: Chemotherapy of Dental Plaque Infections, Oral Sciences Rev 9:23, 1976.
• Slots, J.: Subgingival Microflora and Periodontal Disease, J Clin Periodontol 6:351-382, 1979.[CrossRef][Medline] [Order article via Infotrieve]
• Socransky, S.S.: Microbiology of Periodontal Disease- Present Status and Future Consideration, J Periodontol 48: 497-504,1977.[Medline] [Order article via Infotrieve]
• Feng, K.Y.: The Pharmaceutic Effects of Chinese Herb- Scutellaria baicalensis (Huang-chin). Literature review, Harbin Chinese Medicine 8:37-43, 1965.
• Academy of Traditional Chinese Medicine: Studies on the Chemical Constituents of Traditional Drug Scutellaria baicalensis - Huang-chin, Chinese Medical Journal 7:90, 1973.
• Jiang-su New Medical College: Dictionary of Chinese Drugs, Shanghai: Shanghai People's Publisher, 1977, p. 4146.
• Wang, X.K. and Lee, M.J.: The Extraction and Analysis of Antimicrobial Components of Scutellaria baicalensis, Arch Sichuan Medical College No. 4:97-98, 1959.
• Chen, H.C.: New Pharmacology, 10th ed., Peking: People's Health Publisher, 1974, p. 131.
• Liu, S.S., Ed.: Abstracts of Scientific Articles on Chinese Medicine (1820-1961), Peking: Science Publisher, 1963,p. 578.
• WANG, X.K. (Dept. of Pharmacology, Sichuan Medical College), Personal communication, 1981.
• Spolsky, V.W.; Bhatia, H.L.; and Forsythe, A.: The Effect of an Antimicrobial Mouthwash on Dental Plaque and Gingivitis in Young Adults, J Periodontol 46:685-690, 1975.[Medline] [Order article via Infotrieve]
• Carlson, H.C. and Porter, K.: Inhibitory Effect of a Synthetic Antibiotic Mouthwash (QR-711) on Dental Plaque and Gingivitis in Young Adults, J Periodontol 44:225-227, 1973.[Medline] [Order article via Infotrieve]
• Carlson, H.C.; Porter, K.; and Alms, T.H.: The Effect of an Alexidine Mouthwash on Dental Plaque and Gingivitis, J Periodontol 48:216-218, 1977.[Medline] [Order article via Infotrieve]
• Lobene, R.R. and Soparkar, P.M.: The Effect of an Alexidine Mouthwash on Human Plaque and Gingivitis, JADA 87:848-851, 1973.
• Tinanoff, N.; Brady, J.M.; and Gross, A.: The Effect of NaF and SnF2 Mouthrinses on Bacterial Colonization on Tooth Enamel: TEM and SEM Studies, Caries Res 10:415-426, 1976.[Medline] [Order article via Infotrieve]
• Tinanoff, N.; Hock, J.; Camosci, D.; and Hellden, L.: Effect of Stannous Fluoride Mouthrinse on Dental Plaque Formation, J Clin Periodontol 7:232-241, 1980.[CrossRef][Medline] [Order article via Infotrieve]
• Mazza, J.E.; Newman, M.G.; and Sims, T.N.: Clinical and Antimicrobial Effect of Stannous Fluoride on Periodontitis, J Clin Periodontol 8:203-212, 1981.[CrossRef][Medline] [Order article via Infotrieve]
• Newman, M.G.; Hulem, C.; Colgate, J.; and Anselmo, C.: Antibacterial Susceptibility of Plaque Bacteria, J Dent Res 58:1722-1732, 1979.[Abstract/Free Full Text]
• Yoon, N.A. and Berry, C.W.: The Antimicrobial Effect of Fluorides (Acidulated Phosphate, Sodium and Stannous) on Actinomyces viscosus, J Dent Res 58:1824-1829, 1979.[Abstract/Free Full Text]
• Yoon, N.A. and Newman, M.G.: Antimicrobial Effect of Fluorides on Bacteroides melaninogenicus Subspecies and Bacteroides asaccharolyticus, J Clin Periodontol 7:489-494, 1980.[CrossRef][Medline] [Order article via Infotrieve]
• Hellden, L.; Camosci, D.; Hock, J.; and Tinanoff, N.: Clinical Study to Compare the Effect of Stannous Fluoride and Chlorhexidine Mouthrinse on Plaque Formation, J Clin Periodontol 8:12-16, 1981.[CrossRef][Medline] [Order article via Infotrieve]
• Goodson, J.M.; Haffajee, A.; and Socransky, S.S.: Periodontal Therapy by Local Delivery of Tetracycline, J Clin Periodontol 6:83-92, 1979.[CrossRef][Medline] [Order article via Infotrieve]
• Lindhe, J.; Heijl, L.; Goodson, J.M.; and Socransky, S.S.: Local Tetracycline Delivery Using Hollow Fiber Devices in Periodontal Therapy, J Clin Periodontol 6:141-149, 1979.[CrossRef][Medline] [Order article via Infotrieve]
• Listgarten, M.A.; Lindhe, J.; and Hellden, L.: Effect of Tetracycline and/or Scaling on Human Periodontal Disease, J Clin Periodontol 5:246-271, 1978.[CrossRef][Medline] [Order article via Infotrieve]
• Slots, J.; Mashimo, P.; Levine, M.J.; and Genco, R.J.: Periodontal Therapy in Humans. I. Microbiological and Clinical Effects of a Single Course of Periodontal Scaling and Root Planing, and of Adjunctive Tetracycline Therapy, J Periodontol 59:495-509, 1979.
• Gordon, J.M.; Walker, C.B.; Goodson, J.M.; and Socransky, S.S.: Sensitive Assay for Measuring Tetracycline in Gingival Crevice Fluid, Antimicrob Agents Chemother 17:193-198, 1980.[Abstract/Free Full Text]
• Department of Pharmacology: The Pharmacology of Baicalin, Arch Xian Medical College No. 5:30-34, 1958.

Journal of Dental Research, Vol. 61, No. 9, 1103-1106 (1982)
DOI: 10.1177/00220345820610091501


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Tsao, T.-F. Articles by Horikoshi, A.K. Search for Related Content PubMed PubMed Citation Articles by Tsao, T.-F. Articles by Horikoshi, A.K. Social Bookmarking                         What's this?