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Basic Biological Sciences

Cariogenicity of Human Plaque Lactobacilli in Gnotobiotic Rats

Veterans Administration Medical Center, Miami, Florida 33125

Beatrice O. Adams

Veterans Administration Medical Center, Miami, Florida 33125

Dorothea B. Fitzgerald

Department of Microbiology, University of Miami School of Medicine, Miami, Florida 33125, and

Kenneth W. Knox

Institute of Dental Research, Sydney, Australia

Thirty-two strains of Lactobacilli, comprising eight species and obtained from human dental plaque or other sources, were tested for cariogenic potential in gnotobiotic Sprague-Dawley rats receiving modified cariogenic Diet 2000. Seventeen of these strains were moderately to highly cariogenic, and only one, a strain of Lactobacillus lactis, was scored as non-cariogenic. The molar fissures were the predominant site of caries attack. Primary lesions of the smooth surfaces were infrequently seen, although these surfaces were often secondarily involved by the extension of fissure lesions. The preferential location of caries in the sheltered fissure sites was attributed to their inability to form adherent plaque deposits on the smooth surfaces of the teeth. Caries production by a strain of L. salivarius was equally severe on sucrose- or glucose-containing versions of Diet 2000, but glucose was less supportive of caries development than sucrose for a strain of L. fermentum. It is concluded that a wide variety of lactobacilli may be cariogenic under favorable environmental conditions.

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Journal of Dental Research, Vol. 60, No. 5, 919-926 (1981)
DOI: 10.1177/00220345810600051201


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This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Fitzgerald, R. J. Articles by Knox, K. W. Search for Related Content PubMed PubMed Citation Articles by Fitzgerald, R. J. Articles by Knox, K. W. Pubmed/NCBI databases Substance via MeSH Social Bookmarking                         What's this?