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Binding of Eugenol and O-ethoxybenzoic Acid to Bovine Serum Albumin
Sechiro Fujisawa
School of Dentistry, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113,
Echi Masuhara
Institute for Medical and Dental Engineering, Tokyo Medical and Dental University, 2-3-10 Surugadai, Kanda, Chiyoda-ku, Tokyo 101, Japan,
The binding constants (log K) of eugenol, o-ethoxybenzoic acid, and their analogues, plus other organic compounds widely used in dentistry with bovine serum albumin, were examined with respect to the partition coefficients of these compounds in octanol-water (log P). Linear relationships between log K and log P values were obtained with high relative coefficients. Eugenol and o-ethoxybenzoic acid showed a relatively large log K value.
REFERENCES
- Fujisawa, S. and Masuhara, E.: Binding of Methyl Methacrylate to Bovine Serum Albumin, J Dent Res, in press.
- Silberkweit, M.; Massler, M.; Schour, I.; and Weinmann, J.P.: Effects of Filling Materials on the Pulp in the Rat Incisor, J Dent Res 34:854-869, 1955.[Free Full Text]
- Robert, M.W.; Moffa, J.P.; Hull, J.R.; and Lilly, G.E.: An Evaluation of Zinc Oxide and Eugenol Cement Containing 0-ethoxybenzoic Acid on the Human Deciduous Dental Pulp, Oral Surg 36:416421, 1973.[CrossRef][Medline]
[Order article via Infotrieve]
- Roydhous, R.H. and Weiss, M.E.: Tissue Reaction to Restorative Materials, IADR Progr & Abst 43: No. 807, 1964.
- Avery, J.K.: Response of the Pulp and Dentin to Contact with Filling Materials, J Dent Res 54(B):188-196, 1975.[Free Full Text]
- Fujisawa, S.: The in vitro Biological Evaluation of Dental Cements Using Hemolysis, Jpn J Conserv Dent 21:147-153, 1978.
- Cotmore, J.M.; Burke, A.; Lee, N.H.; and Shapiro, I.M.: Respiratory Inhibition of Isolated Rat Liver Mitochondria by Eugenol, Arch Oral Biol 24:565-568, 1979.[CrossRef][Medline]
[Order article via Infotrieve]
- Tute, M.S.: Principle and Practice of Hansch Analysis: A Guide Structure - Activity Correlation for the Medicinal Chemist, Adv Drug Res 6:65-67, 1971.[Medline]
[Order article via Infotrieve]
- Hansch, C.; Leo, A.; Unger, S.H.; Kim, K.H.; Nikatani, D.; and Lien, E.J.: Aromatic Substituent Constants for Structure - Activity Correlations, J Med Chem 16:1207-1216,1973.[CrossRef][Medline]
[Order article via Infotrieve]
- Stüben, J.: Experimentelle Untersuchungen über die Durchtrittszeit Verschiedener Medikamente durch Dentin, Gemessen mit der Schlierenmethode, Dtsch Zahnärztl Z 8: 662-670,1953.
- Thomas, B.O.A.: Penetration of Phenol in Tooth Structure, J Dent Res 20:435-445, 1941.[Free Full Text]
- Crone, F.L. and Bloch, P.: Penetration of C14-labeled Methyl Methacrylate in the Dentine, Acta Odont Scand 16:247-258, 1958.[Medline]
[Order article via Infotrieve]
- De Crasa, M.G.; De Merlino, N.I.; and Candiotti, A.: Class V Filling with Acrylic Resins C 14. Quantitative Estimation of Residual Monomer in Dental Pulp, J Dent Res 53:697, No. 18, 1974.
- Dankert, J.; 's-Gravenmade, E.J.; and Wemes, J.C.: Diffusion of Formocresol and Glutaraldehyde through Dentin and Cementum, J Endo 2:42-46, 1976.[CrossRef]
- Perreault, J.G. and Massler, M.: Reaction of Odontoblasts to Medicaments Placed in Cavity Preparations in Rat Incisors, JADA 52:533-554,1956.
- Dillingham, E.O.; Mast, R.W.; Bass, G.E.; and Autian, J.: Toxicity of Methyl-and Halogen-substituted Alcohols in Tissue Culture Relative to Structure - Activity Models and Acute Toxicity in Mice, J Pharm Sci 62:22-30, 1973.[CrossRef][Medline]
[Order article via Infotrieve]
- Haldi, J. and Wynn, W.: Protein Fraction of the Blood Plasma and Dental-pulp Fluid of the Dog, J Dent Res 42:1217-1221, 1963.[Free Full Text]
- Jones, A. and Weber, G.: Presence of Arginine Residues at the Strong, Hydrophobic Anion Binding Sites of Bovine Serum Albumin, Biochemistry 10:1335-1339, 1971.[CrossRef][Medline]
[Order article via Infotrieve]
Journal of Dental Research, Vol. 60, No. 4,
860-864 (1981)
DOI: 10.1177/00220345810600041801
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