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Isolated Parotid Acinar Cells from Patients With Cystic Fibrosis. Functional Characterization

Departments of Basic Dental Sciences and Pediatrics, University of Florida Colleges of Medicine and Dentistry, Gainesville, Florida 32610

Studies of the homeostasis and secretory function of isolated parotid acinar cells from patients with cystic fibrosis were conducted. It was demonstrated that the transmembrane fluxes of Na and the muscarinic cholinergic receptor stimulus-secretion coupling were depressed, while the stimulus-secretion coupling of the beta-adrenergic receptor was hyper-reactive.

REFERENCES

• Mangos, J.A.: Cystic Fibrosis. In: The Physiological Basis for Disorders of Biomembranes, Andreoli, T.E., Hoffman, J., and Fanstill, D.D., Eds., New York: Plenum Press, 1978, pp. 941-953.
• Mangos, J.A. and Donnelly, W.H.: Isolated Parotid Acinar Cells from Patients with Cystic Fibrosis: I. Morphology and Composition, J Dent Res, In press.
• Mangos, J.A.: Morphological and Functional Characterization of Isolated Human Parotid Acinar Cells, J Dent Res 58:2028-2035, 1979.[Abstract/Free Full Text]
• Mangos, J.A.; McSherry, N.R.; Butcher, F.; Irwin, K.; and Barber, T.: Dispersed Rat Parotid Acinar Cells. I. Morphological and Functional Characterization, Am J Physiol 229:553-556, 1975.[Abstract/Free Full Text]
• Mangos, J.A.; McSherry, N.R.; Barber, T.; Arvanitakis, S.N.; and Wagner, V.: Dispersed Rat Parotid Acinar Cells. II. Characterization of Adrenergic Receptors, Am J Physiol 229:560-565, 1975.[Abstract/Free Full Text]
• Mangos, J.A.; McSherry, N.R.; and Barber, T.: Dispersed Rat Parotid Acinar Cells. III. Characterization of Cholinergic Receptors, Am J Physiol 229:566-569, 1975.[Abstract/Free Full Text]
• Mangos, J.A.: Role of cGMP in Isolated Rat Parotid Acinar Cells, J Dent Res 57: 989-994, 1978.[Abstract/Free Full Text]
• Mangos, J.A.; Boyd, R.L.; Bouchlas, D.; and Farnham, W.: Calcium and cGMP in Isolated Rat Parotid Acinar Cells, J Dent Res, In press.
• Mangos, J.A.: Characterization of Cholinergic and Adrenergic Receptors in Isolated Human Parotid Acinar Cells, J Dent Res 59: 168-175,1980.[Abstract/Free Full Text]
• Miller, B.E. and Nelson, D.L.: Calcium Fluxes in Isolated Acinar Cells from Rat Parotid, J Biol Chem 252:3629-3636, 1977.[Abstract/Free Full Text]
• Mangos, J.A.; McSherry; and Arvanitakis, S.N.: Autonomic Regulation of Secretion and Transductal Fluxes of Ions in the Rat Parotid, Am J Physiol 225:683-688, 1973.[Free Full Text]
• Martinez, J.R.; Quissell, D.O.: WOOD, D.L.; and GILES, M.: Abnormal Secretory Response to Parasympathomimetic and Sympathomimetic Stimulation from the Submaxillary Gland of Rats Treated with Reserpine, J Pharmacol Exp Therap 194:384-391, 1975.[Abstract/Free Full Text]
• Mangos, J.A.; McSherry, N.R.; Benke, P.J.; and Spock, A.: Studies on the Pathogenesis of Cystic Fibrosis: The Isoproterenol Treated Rat as an Experimental Model. In: Proc. Fifth Intern'l CF Conf, Lawson, D., Ed., Cambridge, England: Cambridge Press, 1969, pp. 25-36.

Journal of Dental Research, Vol. 60, No. 4, 797-804 (1981)
DOI: 10.1177/00220345810600040501


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This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Mangos, J.A. Search for Related Content PubMed PubMed Citation Articles by Mangos, J.A. Social Bookmarking                         What's this?