This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Gibbs, M. Articles by Walker, A.R. Search for Related Content PubMed PubMed Citation Articles by Gibbs, M. Articles by Walker, A.R. Social Bookmarking                         What's this?

Clinical Science

In vivo Enamel Fluoride Uptake from and Caries Inhibition by Topical Fluoride Agents

Institute of Dental Research, University of Alabama School of Dentistry

D.H. Retief

E.L. Bradley

Department of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama 35294

R.E. Taylor

Institute of Dental Research, University of Alabama School of Dentistry

A.R. Walker

Institute of Dental Research, University of Alabama School of Dentistry

Acidulated phosphate fluoride (APF), Duraphat or Fluor Protector, was applied to the molar teeth of rats fed a cariogenic diet. The first maxillary molar teeth were subjected to a microbiopsy procedure for fluoride analysis and the mandibular molars scored for caries. All three topical fluoride agents produced a significant increase in the fluoride content of the outermost 5.0 µm of enamel. Only APF produced a significant reduction in caries incidence at all sites.

REFERENCES

• Mellberg, J.R.; Laakso, P.V.; and Nicholson, C.R.: The Acquisition and Loss of Fluoride by Topically Fluoridated
• Human Tooth Enamel, Arch Oral Biol 11: 1213-1220,1966.[CrossRef][Medline] [Order article via Infotrieve]
• Retief, D.H.; Sorvas, P.G.; Bradley, E.L.; Taylor, R.E.; and Walker, A.R.: In vitro Fluoride Uptake, Distribution and Retention by Human Enamel After One- and 24-hour Application of Various Topical Fluoride Agents, J Dent Res 59:573-582, 1980.[Abstract/Free Full Text]
• Navia, J.M.: Animal Models in Dental Research, Alabama University of Alabama Press, 1977, 282 p.
• Keyes, P.H.: Dental Caries in the Molar Teeth of Rats. II. A Method for Diagnosing and Scoring Several Types of Lesions Simultaneously, J Dent Res 37:1088-1099, 1958.[Free Full Text]
• Retief, D.H.; Navia, J.M.; and Lopez, H.: A Microanalytical Technique for the Estimation of Fluoride in Rat Molar Enamel, Arch Oral Biol 22:207-213, 1977.[CrossRef][Medline] [Order article via Infotrieve]
• Fresen, T.A.; Cox, F.H.; and Witter, M.J.: The Determination of Fluoride in Biological Materials by Means of Gas Chromatography, Pharm Weekblad 103:909-914, 1968.
• Spector, W.S.: Handbook of Biological Data, Philadelphia: Saunders, 1956, 73 p.
• Gilda, J.E.: Studies on the Physical Properties of Rodent Enamel. II. Density Distribution and X-ray Diffraction Pattern, J Dent Res 30:828-836, 1951.[Free Full Text]
• Brudevold, F.; McCann, H.G.; Nils-Son, R.; Richardson, B.; and Coklica, V.: The Chemistry of Caries Inhibition Problems and Challenges in Topical Treatments, J Dent Res 46:3745, 1967.
• Steel, R. and Torrie, J.: Principles and Procedures of Statistics, New York: McGraw-Hill, 1960, pp. 99-160.
• Ostle, B. and Mensing, R.: Statistics in Research, 3rd ed., Iowa City: Iowa State University Press, 1975, pp. 452-561.
• Barr, A.; Goodnight, J.; Sall, J.; and Helwig, J.: A User's Guide to SAS 76, Raleigh: Sparks Press, 1976, pp. 57-65.
• Arends, J. and Schuthof, J.: Fluoride Content in Human Enamel After Fluoride Application and Washing-An in vitro Study, Caries Res 9:363-372, 1975.[Medline] [Order article via Infotrieve]
• Chow, L.C. and Brown, W.E.: Formation of CaHPO4·2H2O in Tooth Enamel as an Intermediate Product in Topical Fluoride Treatments, J Dent Res 54:65-76, 1975.[Abstract/Free Full Text]
• Bang, S. and Kim, Y.J.: Electron Microprobe Analysis of Human Tooth Enamel Coated in vivo with Fluoride-varnish, Helv Odont Acta 17:84-88, 1973.[Medline] [Order article via Infotrieve]
• Konig, K.G.; Muhlemann, H.R.; Schait, A.; and Schmidt, R.: The Effect of Post-eruptive Fluoride Uptake and Enamel Maturation on Dental Caries in Osborne-Mendel Rats, Helv Odont Acta, 9:135-140, 1965.[Medline] [Order article via Infotrieve]
• Riethe, V.P.: Die Anreicherung des Schmelzes von Oberkiefermolaren mit Fluoriden nach Lokaler Applikation von Aminfluorid an Molaren des Unterkiefers bei Osborne-Mendel-Ratten, Dtsch Zahnaerztl Z 23: 154-157,1968.[Medline] [Order article via Infotrieve]
• Tori, B.; Gedalia, I.; and Sharav, Y.: Fluoride Uptake by the Molar Teeth Surfaces of Mature Rats Following Intraperitoneal Fluoride Administration, Caries Res 4:283-292, 1970.[Medline] [Order article via Infotrieve]
• Gilda J.E.: Studies on the Physical Properties of Rodent Enamel. I. The Manly-Hodge Separation Method as Applied to the Teeth of the Rat and the Hamster, J Dent Res 30:445-452,1951.
• Heuser, H. and Schmidt, H.F.M.: Die Wirkung des Kariesprophylaktikums Fluor-lack in Tierversuch mit Albinoratten, Dtsch Zahn Mund Kieferheilkd 47:133-140, 1966.
• Riethe, P. and Weinman, K.: Caries Inhibition with Fluoride Gel and Fluoride Varnish in Rats, Caries Res 4:63-68, 1970.[Medline] [Order article via Infotrieve]
• Navia, J.M. and Lopez, H.: Sources of Variability in Rat Caries Studies: Weaning Age and Diet Fed During Tooth Eruption, J Dent Res 56:222-227, 1977.[Abstract/Free Full Text]
• Weatherell, J.A.; Robinson, C.; and Deutsch, D.: Site Discrimination in the Analysis of Rat Molar Enamel J Dent Res 58C: 1239, No. 74, 1979.

Journal of Dental Research, Vol. 60, No. 4, 770-775 (1981)
DOI: 10.1177/00220345810600040101


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				D.G.A. Nelson, W.L. Jongebloed, and J. Arends Morphology of Enamel Surfaces Treated with Topical Fluoride Agents: SEM Considerations Journal of Dental Research, December 1, 1983; 62(12): 1201 - 1208. [Abstract] [PDF]

This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Gibbs, M. Articles by Walker, A.R. Search for Related Content PubMed PubMed Citation Articles by Gibbs, M. Articles by Walker, A.R. Social Bookmarking                         What's this?