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Kinetics of Cell Proliferation and Migration Associated with Orthodontically-induced Osteogenesis
W. EugeneRoberts
Departments of Anatomy and Orthodontics, University of the Pacific, 2155 Webster Street, San Francisco, California 94115
Donald C. Chase
Department of Oral Surgery, University of Tennessee Memorial Hospital, Knoxville, Tennessee 27920
Cell kinetics of rat molar periodontal ligament (PDL) during orthodontically-induced osteogenesis revealed: 1) primary growth fraction of 59%, 2) proliferating cells from throughout the PDL migrate toward the bone surface, 3) preosteoblasts, capable of forming osteoblasts without synthesizing DNA, are present in the PDL, 4) osteoblasts are derived from local PDL cells, and 5) cell death is a characteristic feature of the osteogenic response.
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Journal of Dental Research, Vol. 60, No. 2,
174-181 (1981)
DOI: 10.1177/00220345810600021501
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