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Basic Biological Sciences

Epidermal Growth Factor and Proliferation of Odontogenic Cells in Culture

Department of Dental Medicine and Surgery, University of Melbourne, Faculty of Dental Science, 711 Elizabeth Street, Melbourne, Victoria 3000, Australia

P.C. Reade

Department of Dental Medicine and Surgery, University of Melbourne, Faculty of Dental Science, 711 Elizabeth Street, Melbourne, Victoria 3000, Australia

The proliferation of bovine odontogenic epithelial (OE) and mesenchymal (OM) cells cultured in the presence of varying concentrations of epidermal growth factor (EGF) was examined. After a delay of two to three d, EGF-supplemented cultures contained significantly more cells than did controls. This effect was dose-dependent, was maximal at 10-9 g EGF/ml for OE and 10-8 g EGF/ml for OM, and was dependent on the presence of serum in the culture medium. The results suggest the possibility that EGF may play a role in the control of odontogenic cell proliferation in vivo.

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Journal of Dental Research, Vol. 60, No. 12, 1977-1982 (1981)
DOI: 10.1177/00220345810600120901


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This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Steidler, N.E. Articles by Reade, P.C. Search for Related Content PubMed PubMed Citation Articles by Steidler, N.E. Articles by Reade, P.C. Social Bookmarking                         What's this?