|
Sign In to gain access to subscriptions and/or personal tools.
|
Long-term Antiplaque, Anticalculus, and Antigingivitis Effects of Benzethonium/Polymer Complex in Beagle Dogs
A. Gaffar
Colgate-Palmolive Research Center, 909 River Road, Piscataway, New Jersey 08854
M.C. Solis-Gaffar
Colgate-Palmolive Research Center, 909 River Road, Piscataway, New Jersey 08854
E. Tavss
Colgate-Palmolive Research Center, 909 River Road, Piscataway, New Jersey 08854
H.W. Marcussen
Colgate-Palmolive Research Center, 909 River Road, Piscataway, New Jersey 08854
K.N. Rustogi
Colgate-Palmolive Research Center, 909 River Road, Piscataway, New Jersey 08854
An electrostatic complex of 0.1% benzethonium chloride (BTC) plus 0.05% copolymer of methoxyethylene and maleic acid was evaluated in vitro for antibacterial effect. The complex by itself showed as much antibacterial activity as 0.1% BTC. The adsorption of 14C-BTC on saliva-coated hydroxyapatite disks and teeth in vitro was lower from the complex than the BTC solution, although in vivo activity was the same. The complex, BTC, and polymer solutions were evaluated in a 28-week study in 16 beagle dogs against plaque, gingivitis, and calculus formation. BTC and the complex significantly ( = 0.05) reduced plaque and gingivitis. There was no significant difference between the two active groups. BTC (0.1%) significantly increased calcified deposits at 22-28 wk compared to the water control group, while the complex and the polymer groups showed significantly ( = 0.05) less calculus. Thus, the complex was not only effective in vivo, but also significantly ( = 0.05) reduced tendencies of cationic antibacterials to induce calcified deposits on teeth.
REFERENCES
- Loesche, W.J.: Chemotherapy of Dental Plaque Infections, Oral Sci Res 9:63-105, 1976.
- Gaffar, A.; Donohue, J.J.; Davis, C.B.; and Carroll, D.L.: Studies on Antibacterially-induced Staining, J Dent Res 58: 210-211, 1979.
- Loë, H.; Rindom Schiott, C.; Glavind, L.; and Karring, T.: Two-year Oral Use of Chlorhexidine in Man. General Design and Clinical Effects, J Periodont Res 11:135-144, 1976.[CrossRef][Medline]
[Order article via Infotrieve]
- Cullum, D.C.: Determination of Cationic Surfactants by Anionic Detergents, Third Int Congr Surface Activity (Cologne) 3:42-45, 1960.
- Hennessey, T.D.: Some Antibacterial Properties of Chlorhexidine, J Perio 8 (Suppl. 12):61-62,1973.
- Gaffar, A.; Marcussen, H.W.; Solis-Gaffar, M.C.; and Rustogi, K.N.: Longterm Antiplaque, Gingivitis, and Calculus Effects of Benzethonium Chloride in Beagle Dogs, J Periodont Res 15:107-110, 1980.[CrossRef][Medline]
[Order article via Infotrieve]
- Dichter, M.; Mangaraj, D.; and King, W.J.: Treatment of Teeth, U.S. Patent 3,956,480, 1976.
- Rolla, G.; Loë, H.; and Rindom Schiott, C.: The Affinity of Chlorhexidine for Hydroxyapatite and Salivary Mucins, J Periodont Res 5:90-95, 1970.[CrossRef][Medline]
[Order article via Infotrieve]
- Saito, S. and Kitamura, K.: Counterion Effect of Tetra-alkyl Ammonium and Long Chain Alkyl Ammonium Salts in the Interaction with Polymers, J Colloid and Inf Sci 35:346-353,1971.[CrossRef]
- Packter, A.: Association of Organic Quaternary Ammonium Cations with Polyacrylates. Conductivity and Viscosity Measurements, J Poly Sci 2A:2771-2782, 1964.
- Ackart, W.B.; Camp, R.L.; Wheel-Wright, W.L.; and Byck, J.S.: Antimicrobial Polymers, J Biomed Mater Res 9:55-68, 1975.[CrossRef][Medline]
[Order article via Infotrieve]
- Shedlovsky, L.: Dental Preparation Containing Polymeric Polyelectrolyte, U.S. Patent 3,429,963, 1969.
- Gjermo, P.; Baastaad, K.L.; and Rolla, G.: The Plaque-inhibiting Capacity of 11 Antibacterial Compounds, J Periodont Res 5:317-319, 1970.
- Compton, F.H. and Beagrie, G.S.: Inhibitory Effect of Benzethonium Chloride Mouthrinses on Human Dental Plaque and Gingivitis, J Clin Perio 2:33-34, 1975.[CrossRef]
Journal of Dental Research, Vol. 60, No. 11,
1897-1903 (1981)
DOI: 10.1177/00220345810600111201
 CiteULike  Complore  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter What's this?
|
|
