|
Sign In to gain access to subscriptions and/or personal tools.
|
Evaluation of Irradiated Mandibles Using Emission Tomography, Bone Scans, and Radiography
Michael D. Rohrer
The University of Michigan Medical Center, Ann Arbor, Michigan 48109
Louis T. Kircos
The University of Michigan Medical Center, Ann Arbor, Michigan 48109
James H. Thrall
The University of Michigan Medical Center, Ann Arbor, Michigan 48109
Young Kim
The University of Michigan Medical Center, Ann Arbor, Michigan 48109
Juan V. Fayos
The University of Michigan Medical Center, Ann Arbor, Michigan 48109
This study compared radiographs, bone scans, and computed emission tomograms with histologic findings in irradiated mandibles of adult Rhesus monkeys. Although osteocytes were lost in the path of the beam, many vessels were partially or totally occluded, the periosteum degenerated, the marrow became fibrotic, and cancellous bone proliferated abundantly, no changes were noted with radiography, conventional bone scanning, or computed emission tomograms. These clinical methods of examination may misrepresent the true condition of irradiated bone because of inadequate sensitivity or balance among factors that control radioactive tracer uptake in bone.
REFERENCES
- Keyes, J.W.; Orlandea, N.; Heet-Derks, W.J.; Leonard, P.F.; and Rogers, W.L.: The Humongotron - A Scintillation Camera Transaxial Tomograph, J Nucl Med 18:381-387,1977.[Abstract/Free Full Text]
- Kay, D.B.; Keyes, J.W.; and Simon, W.: Radionuclide Tomographic Image Reconstruction Using Fourier Transformation Techniques, J Nucl Med 15:981-986, 1974.[Abstract/Free Full Text]
- Orton, C.G. and Ellis, F.: A Simplification in the Use of the NSD Concept in Practical Radiotherapy, Br J Radiol 46:529-537,1973.[Abstract/Free Full Text]
- Rohrer, M.D.; Kim, Y.; and Fayos, J.V.: The Effect of Cobalt-60 Irradiation on Monkey Mandibles, Oral Surg 48:424440, 1979.
- Bond, W.R.; Matthews, J.L.; and Fin-Ney, J.W.: The Influence of Regional Oxygenation on Osteoradionecrosis, Oral Surg 23:99-113, 1967.[CrossRef][Medline]
[Order article via Infotrieve]
- Medak, H. and Burnett, G.W.: The Effect of X-ray Irradiation on the Oral Tissue of the Macacus Rhesus Monkey, Oral Surg 7:778-786, 1954.[CrossRef][Medline]
[Order article via Infotrieve]
- Bell, D.G.; McAfee, J.G.; and Constable, W.C.: Local Radiation Damage to Bone and Marrow Demonstrated by Radioisotope Imaging, Radiology 92:1083-1088, 1969.[Medline]
[Order article via Infotrieve]
- Garcia, D.A.; Tow, K.K.; and Wells, H.: Tc-99m Polyphosphate Uptake by Resorbing Bone, J Nucl Med 16:528, 1975 (Abst).
- Van Dyke, D.C.: Anger, H.O.: Yano, Y.; and Bozzini, C.: Bone Blood Flow as Shown with 18F and the Positron Camera, Am J Physiol 209:65-70, 1965.[Abstract/Free Full Text]
- King, M.A.; Kilpper, R.W.; and Weber, D.A.: A Model for Local Accumulation of Bone Imaging Radiopharmaceuticals, J Nucl Med 18:1106-1111,1977.[Abstract/Free Full Text]
- Winchell, H.A.: Mechanisms for Radiopharmaceutical Localization, J Appl Radiol 5:176-177,206-207,1976.
- Jones, A.G.; Francis, M.D.; and Davis, M.A.: Bone Scanning: Radionuclide Reaction Mechanisms, Sem Nucl Med 6:3-18, 1976.[CrossRef][Medline]
[Order article via Infotrieve]
- Garnett, E.S.; Bowen, B.M.; Coates, G.; and Nahmias, C.: An Analysis of Factors Which Influence the Local Accumulation of Bone-seeking Radiopharmaceuticals, Invest Radiol 10:564-568, 1975.[CrossRef][Medline]
[Order article via Infotrieve]
- Genant, H.K.; Bautovich, G.J.; Singh, M.; Lathrop, K.A.; and Harper, P.V.: Bone-seeking Radionuclides: An in vivo Study of Factors Affecting Skeletal Uptake, Radiology 113:373-382, 1974.[Medline]
[Order article via Infotrieve]
- Regezi, J.A.; Courtney, R.M.; and Kerr, D.A.: Dental Management of Patients Irradiated for Oral Cancer, Cancer 38:994-1000, 1976.[CrossRef][Medline]
[Order article via Infotrieve]
- Bedwinek, J.M.; Shukovsky, L.J.; Fletcher, G.H.; and Daley, T.E.: Osteonecrosis in Patients Treated with Definitive Radiotherapy for Squamous Cell Carcinomas of the Oral Cavity and Naso- and Oro-pharynx, Radiology 119:665-667, 1976.[Abstract]
- Brown, M.L.; Keyes, J.W.; Leonard, P.F.; Thrall, J.H.; and Kircos, L.T.: Facial Bone Scanning by Emission Tomography, J Nucl Med 18:1184-1188, 1977.[Abstract/Free Full Text]
- Morley, T.R.; Short, M.D.; and Dow-Sett, DJ: Femoral Head Activity in Perthe's Disease: Clinical Evaluation of a Quantitative Technique for Estimating Tracer Uptake, J Nucl Med 19:884-890, 1978.[Abstract/Free Full Text]
Journal of Dental Research, Vol. 59, No. 12,
2032-2037 (1980)
DOI: 10.1177/00220345800590120201

CiteULike Complore Connotea Del.icio.us Digg Reddit Technorati Twitter What's this?
|
|