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The Effects of Epinephrine, Norepinephrine, and Phenylephrine on the Types of Proteins Secreted by Rat Salivary Glands
K. Abe
Department of Oral Biochemistry, Gifu College of Dentistry, Gifu, Japan
K. Yoneda
Department of Oral Biochemistry, Gifu College of Dentistry, Gifu, Japan
R. Fujita
Department of Oral Biochemistry, Gifu College of Dentistry, Gifu, Japan
Y. Yokota
Department of Oral Biochemistry, Gifu College of Dentistry, Gifu, Japan
C. Dawes
Department of Oral Biology, Faculty of Dentistry, University of Manitoba, Winnipeg, Canada, R3E OW3
The types of proteins secreted by rat submandibular glands in response to secretory stimulation with epinephrine, norepinephrine, or phenylephrine were dose-dependent. At relatively high doses the proteins secreted were characteristic of -adrenergic stimulation, whereas at low doses they were characteristic of β-adrenergic stimulation.
REFERENCES
- Ahlquist, R.P.: A Study of the Adrenotropic Receptors, Am J Physiol 153:586-600,1948.[Free Full Text]
- Schramm, M. and Selinger, Z.: The Function of
- and β-adrenergic Receptors and a Cholinergic Receptor in the Secretory Cell of Rat Parotid Gland, in Advances in Cytopharmacology. Vol. 2, Ceccarelli, B., Clementi, F., and Meldolesi, J., Eds., New York: Raven Press, pp. 29-32, 1974. - Leslie, B.A.; Putney, J.W., Jr.; and Sher-Man, J.M.: a-adrenergic, β-adrenergic and Cholinergic Mechanisms for Amylase Secretion by Rat Parotid Gland in vitro, J Physiol 260:351-370, 1976.[Abstract/Free Full Text]
- Matthews, R.W.: The Effects of Autonomic Stimulation upon the Rat Submandibular Gland, Arch Oral Biol 19:989-994, 1974.[CrossRef][Medline]
[Order article via Infotrieve]
- Abe, K. and Dawes, C.: The Effects of Electrical and Pharmacological Stimulation on the Types of Proteins Secreted by Rat Parotid and Submandibular Glands, Arch Oral Biol 23:367-372,1978.[CrossRef][Medline]
[Order article via Infotrieve]
- Fraser, A.; Haugaard, E.S.; Mendels, J.; and Haugaard, N.: Effects of Intracellular Lithium on Epinephrine-induced Accumulation of Cyclic AMP in Skeletal Muscle, Biochemical Pharmacol 24:2773-2277,1975.
- Imai, S.; Shigei, T.; and Hashimoto, K.: Cardiac Actions of Methoxamine with Special Reference to its Antagonistic Action to Epinephrine, Circulation Res 9:552-560, 1961.[Abstract/Free Full Text]
- Babad, H.; Ben-Zvi, R.; Bdolah, A.; and Schramm, M.: The Mechanism of Enzyme Secretion by the Cell. IV. Effects of Inducing Substances and Inhibitors on Amylase Secretion by Rat Parotid Slices, Eur J Biochem 1:96-101, 1967.[Medline]
[Order article via Infotrieve]
- Bdolah, A. and Schramm, M.: The Function of 3'5'Cyclic AMP in Enzyme Secretion, Biochem Biophys Res Commun 18: 452-454, 1965.[CrossRef][Medline]
[Order article via Infotrieve]
- Grand, R.J.; Chong, D.A.; Ryan, S.J.: Postnatal Development of Adenylate Cyclase in Rat Salivary Glands: Patterns of Hormonal Sensitivity, Am J Physiol 228:608-612, 1975.[Abstract/Free Full Text]
- Butcher, F.R.; Goldman, J.A.; and Nemerovski, M.: Effect of Adrenergic Agents an a-Amylase Release and Adenosine 3',5'-monophosphate Accumulation in Rat Parotid Tissue Slices, Biochim Biophys Acta 392:82-94, 1975.[Medline]
[Order article via Infotrieve]
- Clarke, W.R.; Jones, L.R.; and Lefko-Witz, R.J.: Hepatic a-adrenergic Receptors, J Biol Chem 253:5975-5979, 1978.[Abstract/Free Full Text]
- Massagué, J. and Guinovart, J.J.: Insulin Counteraction of a-adrenergic Effects on Liver Glycogen Metabolism, Biochim Biophys Acta 543:269-272, 1978.[Medline]
[Order article via Infotrieve]
- Chan, T.M. and Exton, J.H.: Studies on a-adrenergic Activation of Hepatic Glucose Output, J Biol Chem 253:6393-6400, 1978.[Free Full Text]
- Sherline, P.; Lynch, A.; and Glins-Mann, W.H.: Cyclic AMP and Adrenergic Receptor Control of Rat Liver Glycogen Metabolism, Endocrinol 91:680-690, 1972.[Abstract/Free Full Text]
- Batzri, S.; Selinger, Z.; Schramm, M.; and Robinovitch, M.R.: Potassium Release Mediated by the Epinephrine a-receptor in Rat Parotid Slices, J Biol Chem 248:361-368,1973.[Abstract/Free Full Text]
- Michell, R.H. and Jones, L.M.: Enhanced Phosphatidylinositol Labeling in Rat Parotid Fragments Exposed to a-adrenergic Stimulation, Biochem J 138:47-52, 1974.[Medline]
[Order article via Infotrieve]
- Harfield, B. and Tenenhouse, A.: Effect of EGTA on Protein Release and Cyclic AMP Accumulation in Rat Parotid Gland, Canad J Physiol Pharmacol 51:997-1001,1973.[Medline]
[Order article via Infotrieve]
- Pohto, P.: Catecholamine-induced Salivary Gland Enlargement in Rats, Acta Odont Scand 24:Supp 45, 1966.
- Emmelin, N.; Holmberg, J.; and Ohlin, P.: Receptors for Catecholamines in the Submaxillary Glands of Rats, Brit J Pharmacol 25:134-138, 1965.[Medline]
[Order article via Infotrieve]
- Byyny, R.L.; Orth, D.N.; Cohen, S.; and Doyne, E.S.: Epidermal Growth Factor: Effects of Androgens and Adrenergic Agents, Endocrinol 95:776-782, 1974.[Abstract/Free Full Text]
- Michelakis, A.M.; Menzie, J.W.; and Yoshida, H.: Sympathetic Nervous System and Renin Release from Submaxillary Glands in vitro, Am J Physiol 231:551-554, 1976.[Abstract/Free Full Text]
- Wallace, L.J. and Partlow, L.M.: a-adrenergic Regulation of Secretion of Mouse Saliva Rich in Nerve Growth Factor, Proc Natl Acad Sci USA 73:4210-4214, 1976.[Abstract/Free Full Text]
- Wallace, L.J.; Partlow, L.M.; and Ellis, M.E.: a-adrenergic Regulation of the Secretion of an Anticomplementary Factor in Mouse Saliva, Proc Soc Exp Biol Med 152: 99-104, 1976.[CrossRef][Medline]
[Order article via Infotrieve]
- Hosoi, K.; Aoyama, K.; and Ueha, T.: Regulation of the Secretory Process of Glandular Components from the Convoluted Tubular Cells of the Mouse Submandibular Gland, J Dent Res 57:87-90, 1978.[Abstract/Free Full Text]
- Roberts, M.L.: Secretion of Epidermal Growth Factor. The Role of Calcium in Stimulus-coupling and Structural Modification of the Growth Factor Molecule During Secretion, Biochim Biophys Acta 540:246-252, 1978.[Medline]
[Order article via Infotrieve]
- Gjörstrup, P.: Effects of ICI 66082, a New β-adrenoceptor Blocking Drug, on the Submaxillary Gland of the Rat, Experientia 31:550, 1975.[CrossRef][Medline]
[Order article via Infotrieve]
- Yoshida, Y.; Sprecher, R.L.; Schneyer, C.A.; and Schneyer, L.H.: Role of β-receptors in Sympathetic Regulation of Electrolytes in Rat Submaxillary Saliva, Proc Soc Exp Biol Med 126:912-916, 1967.[CrossRef]
- Abe, K. and Dawes, C.: Circadian Variations in Pilocarpine and Isoprenaline-induced Protein Secretion by Rat Parotid Gland, Arch Oral Biol 20:543-546, 1975.[CrossRef][Medline]
[Order article via Infotrieve]
- Lowry, O.H.; Rosebrough, N.J.; Farr, A.L.; and Randall, R.J.: Protein Measurement with the Folin Phenol Reagent, J Biol Chem 193:265-275, 1951.[Free Full Text]
- Dawes, C.: Disodium Ethylenediaminetetraacetate as an Aid for the Reconstitution of Lyophilized Human Salivary Proteins before Paper Electrophoresis, Arch Oral Biol 8: 653-656, 1963.[CrossRef]
- Kapitany, R.A. and Zebrowski, E.J.: A High Resolution PAS Stain for Polyacrylamide Gel Electrophoresis, Analyt Biochem 56:361-369, 1973.[CrossRef][Medline]
[Order article via Infotrieve]
- Meyer, T.S. and Lamberts, B.L.: The Use of Wool Fast Blue BL for the Electrophoresis of Human Parotid Saliva Proteins in Polyacrylamide Gel, Arch Oral Biol 13:839-840, 1968.[CrossRef][Medline]
[Order article via Infotrieve]
- Gorovsky, M.A.; Carlson, K.; and Rosenbaum, J.L.: Simple Method for Quantitative Densitometry of Polyacrylamide Gels Using Fast Green, Analyt Biochem 35: 359-370, 1970.[CrossRef][Medline]
[Order article via Infotrieve]
- Petersen, O.H. and Pedersen, G.L.: Membrane Effects Mediated by Alpha-and Beta-adrenoceptors in Mouse Parotid Acinar Cells, J Membrane Biol 16:353-362, 1974.[CrossRef][Medline]
[Order article via Infotrieve]
- Ohlin, P.: Isoprenaline as a Secretory Agent in Salivary Glands, Acta Universitatis Lundensis 17:1-8, Section II, 1964.
- Nordenfelt, I. and Ohlin, P.: Super-sensitivity of Salivary Glands of Rabbits, Acta Physiol Scand 41:12-17, 1957.[CrossRef][Medline]
[Order article via Infotrieve]
- Emmelin, N. and Stromblad, B.C.R.: Effects of Guanethidine on Salivary Glands, Experientia 19:104-105, 1963.[CrossRef]
- Birbari, A.: Effect of Sympathetic Nervous System on Renin Release, Am J Physiol 220: 16-18, 1971.[Free Full Text]
- Cross, M.H. and Houlihan, R.T.: Sympathoadrenomedullary Response of the Rat to High Oxygen Exposures, J Appl Physiol 27:523-527, 1969.[Free Full Text]
Journal of Dental Research, Vol. 59, No. 10,
1627-1634 (1980)
DOI: 10.1177/00220345800590101201

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