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Diphenylhydantoin Induced Gingival Hyperplasia in Ferrets: A Precautionary Note

Department of Physiology and Pharmacology, University of Pittsburgh, School of Dental Medicine, Pittsburgh, Pennsylvania 15261

James W. Smudski

Department of Physiology and Pharmacology, University of Pittsburgh, School of Dental Medicine, Pittsburgh, Pennsylvania 15261

Sarah Hopper

Department of Physiology and Pharmacology, University of Pittsburgh, School of Dental Medicine, Pittsburgh, Pennsylvania 15261

REFERENCES

• Kimball, O.P.: The treatment of epilepsy with sodium diphenylhydantoin. JAMA 112: 1244-1245, 1939.[Abstract/Free Full Text]
• Staple, P.H.: The adrenal glands and gingival hyperplasia due to phenytoin sodium. Lancet 265:600-601, 1953.[Medline] [Order article via Infotrieve]
• Van Der Kwast W.: Speculations regarding the nature of gingival hyperplasia due to diphenylhydantoin sodium. Acta Med Scand 153:300-405, 1956.
• Shafer, N.G.: Cell-stimulating effects of diphenylhydantoin sodium in tissue cultures. J Dent Res 40:1680, 1961.
• Larmas, L. and Pavnio, K.: Epithelial hyperplasia in hydantoin-induced hyperplastic and normal human gingiva. Proc Finn Dent Soc 72:177-179, 1976.[Medline] [Order article via Infotrieve]
• Nuki, K. and Cooper, S.H.: The role of inflammation in the pathogenesis of gingival enlargement during the administration of diphenylhydantoin sodium in cats. J Periodont Res 7:102-110, 1972.[CrossRef][Medline] [Order article via Infotrieve]
• Steinberg, A.D., Alvarez, J.A. and Jeffay, H.: Lack of relationship between the degree of induced gingival hyperplasia and the concentration of diphenylhydantoin in various tissues of ferrets. J Dent Res 51: 657-662, 1972.[Abstract/Free Full Text]
• Dill, W.S.; Chucot, L.; Chang, T.; and Glazko, A.J.: Simplified benzophenone procedure for determination of diphenylhydantoin in plasma. Clin Chem 17:1200-1201, 1971.[Medline] [Order article via Infotrieve]
• King, J.D.: Experimental and clinical observations on gingival hyperplasia due to "Epanutin." British Dental Journal 96:237-247, 1954.

Journal of Dental Research, Vol. 58, No. 8, 1812-1814 (1979)
DOI: 10.1177/00220345790580081101


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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Moore, P. A. Articles by Hopper, S. Search for Related Content PubMed PubMed Citation Articles by Moore, P. A. Articles by Hopper, S. Social Bookmarking                         What's this?