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Journal of Dental Research
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IgG Subclasses in Human Periodontal Disease: III. Serum Concentrations of IgG Subclass Immunoglobulins and Circulating Immune Complexes

Bruce F. Mackler

The Dental Science Institute, University of Texas Health Science Center, Houston, Texas 77025

Peter Schur

Department of Medicine, Robert B. Brigham Hospital, Harvard Medical School, Boston, Massachusetts 02111

Thomas Waldrop

Wilford Hall USAF Medical Center, Lackland Air Force Base, Texas

Elbert Coker

The Dental Science Institute, University of Texas Health Science Center, Houston, Texas 77025

Roger Rossen

Department of Microbiology and Immunology, Baylor College of Medicine; and the Laboratory for Immunology Research at the Veterans Administration Hospital, Houston, Texas

No quantitative changes in serum IgG subclass concentrations could be correlated clinically with periodontal disease, despite evidence of restrictive IgG subclass antibody responses in inflamed gingiva. Serum from periodontal patients also lacked circulating immune complexes.

REFERENCES

  • Mackler, B.F.; Frostad, K.D.; Robertson, P.B.; and Levy, B.M.; Immunoglobulin-bearing Lymphocytes and Plasma Cells in Human Periodontal Disease, J Periodont Res 12:3745, 1977.
  • Mackler, B.F.; Waldrop, T.C.; Schur, P.; Robertson, P.B.; and Levy, B.M.: IgG Subclasses in Human Periodontal Disease. I. Distribution and Incidence of IgG Subclass Bearing Lymphocytes and Plasma Cells, J Periodont Res 13:109-119, 1978a.[Medline] [Order article via Infotrieve]
  • Mackler, B.F.; Faner, R.M.; Schur, P.; Wright, T.E. III; and Levy, B.M.: IgG Subclasses in Human Periodontal Disease. II. Cytophilic and Membrane IgG Subclass Immunoglobulins, J Periodont Res 13:433-445,1978b.[Medline] [Order article via Infotrieve]
  • Schur, P.H.; Rosen, F.; and Norman, M.E.: IgG Subclasses in Normal Children, Pediatric Res 13:181-189, 1979.[Medline] [Order article via Infotrieve]
  • Genco, R.J.; and Krygier, G.: Localization of Immunoglobulins, Immune Cells and Complement in Human Gingiva, J Periodont Res 7 (Supp 10):30-31, 1972.
  • Genco, R.J.; Mashimo, P.A.; Krygier, G.; and Ellison, S.A.: Antibody-mediated Effects on the Periodontium, J Periodontol 45:330-337, 1974.[Medline] [Order article via Infotrieve]
  • Clagett, J.A.; and Page, R.C.: Insoluble Immune Complexes and Chronic Periodontal Diseases in Man and the Dog, Arch Oral Biol 23:153-165,1978.[Medline] [Order article via Infotrieve]
  • Rossen, R.D.; Zubler, H.; Day, N.K.; Reisberg, M.A.; Morgan, A.C.; Gut-Terman, J.U.; and Hersh, E.M.: Detection of Immune Complex-like Materials in Cancer Patients' Sera: A Comparative Study of Results Obtained with the Clq Deviation and Clq Binding Tests, J Lab Clin Med 91(2): 191-204, 1978.[Medline] [Order article via Infotrieve]
  • Ramfjord, S.P.: Indices for Prevalence and Incidence of Periodontal Disease, J Periodontol 30:51-62, 1959.
  • Löe, H.; and Silness, J.: Periodontal Disease in Pregnancy. 1. Prevalence and Severity, Acta Odont Scand 21:532-551, 1963.
  • Löe, H.: The Gingival Index, the Plaque Index and the Retention Index Systems, J Periodontol 38:610-616, 1967.[Medline] [Order article via Infotrieve]
  • Page, R.C.; and Schroeder, H.E.: Pathogenesis of Inflammatory Periodontal Disease. A Summary of Current Work, Lab Invest 34:235-241, 1976.[Medline] [Order article via Infotrieve]

Journal of Dental Research, Vol. 58, No. 7, 1701-1704 (1979)
DOI: 10.1177/00220345790580070901


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This Article
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