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A Comparison of the Effects of Endotoxin Upon Fibroblast Proliferation and Macromolecular Syntheses

Procter & Gamble Company, Miami Valley Laboratories, P.O. Box 39175, Cincinnati, OH 45247

W.G. Dutton

Procter & Gamble Company, Miami Valley Laboratories, P.O. Box 39175, Cincinnati, OH 45247

The effects of Escherichia coli endotoxin upon mouse L929 cell proliferation, DNA synthesis, protein synthesis, and proline incorporation were determined. It was found that a level of endotoxin which inhibited cell proliferation prompted a similar inhibition of DNA synthesis and overall cell protein synthesis. In contrast, endotoxin was shown to inhibit incorporation of proline into cell protein to a significantly greater extent.

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Journal of Dental Research, Vol. 58, No. 6, 1634-1639 (1979)
DOI: 10.1177/00220345790580061301


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