This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Vittek, J. Articles by Southren, A. L. Search for Related Content PubMed PubMed Citation Articles by Vittek, J. Articles by Southren, A. L. Social Bookmarking                         What's this?

Cellular Regulation of the Metabolism of Androgens in Rat Oral Mucosa. II. Product Activation of 17 β-hydroxysteroid Oxidoreductase Enzyme System

Department of Medicine, New York Medical College, New York 10029, U.S.A., Department of Dentistry, New York Medical College, New York 10029, U.S.A.

Gary G. Gordon

Department of Medicine, New York Medical College, New York 10029, U.S.A., Department of Dentistry, New York Medical College, New York 10029, U.S.A.

Sydney C. Rappaport

Department of Medicine, New York Medical College, New York 10029, U.S.A., Department of Dentistry, New York Medical College, New York 10029, U.S.A.

A. Louis Southren

Department of Medicine, New York Medical College, New York 10029, U.S.A., Department of Dentistry, New York Medical College, New York 10029, U.S.A.

Product activation of 17β-hydroxysteroid oxidoreductase for testosterone and androstenedione was established using the enzyme preparation from rat oral mucosa. It is suggested that this activation could be due to the conformational changes of the enzyme.

REFERENCES

• Vittek, J.; Altman, K.; Gordon G.G.; and Southren, A.L.: The metabolism of 7-3H-testosterone by rat oral mucosa: Effect of medroxyprogesterone acetate on testosterone A-ring reductase activity, Endocrinology 95: 1473-1477, 1974.[Abstract/Free Full Text]
• Vittek, J.; Altman K.; Rappaport, S.C.; Gordon, G.G.; Hagedoorn, J.; and Southren, A.L.: Effect of progestins on androgen 4-3-ketosteroid-5-A-ring reductase system in rat oral mucosa, J Dent Res 57:511-519, 1978.[Abstract/Free Full Text]
• El Attar, T.M.A.: The in vitro conversion of male sex steroid 1,2-3H-androstenedione in normal and inflamed human gingiva, Arch Oral Biol 19:1185-1190, 1974.[CrossRef][Medline] [Order article via Infotrieve]
• El Attar, T.M.A. and Hugoson, A.: The in vitro conversion of female sex steroid, oestrone, in normal and inflamed human gingiva, Arch Oral Biol 19:425-429, 1974.[CrossRef][Medline] [Order article via Infotrieve]
• Vittek, J.; Gordon, G.G.; Rappaport, S.C.; and Southren, A.L.: Effect of plasma progesterone on 4-3-ketosteroid-5-reductase activity in human gingiva and its biological significance, J Dent Res. 57:Abstract 946,1978.
• Oshima, H.; Sarada, T.; Ochiai, K. and Tamaoki, B.: 4-5-hydrogenase in immature rat testes: Its intracellular distribution, enzyme kinetics, and influence of administered gonadotropins and testosterone propionate, Endocrinology 86:1215-1224, 1970.[Abstract/Free Full Text]
• Gordon, G.G.; Altman, K.; Southren, A.L. and Olivo, J.: Human hepatic testosterone A-ring reductase activity: Effect of medroxyprogesterone acetate, J Clin Endocrinol Metab 32:457-461, 1971.[Abstract/Free Full Text]
• Altman, K.; Gordon, G.G.; Southren, A.L.; Vittek, J.; and Wilker, S.: Induction of hepatic testosterone A-ring reductase by medroxyprogesterone acetate, Endocrinology 90:1252-1260, 1972.[Abstract/Free Full Text]
• Gordon, G.G.; Southren, A.L.; Cala-Nog, A.; Olivo, J.; and Rafii, F.: The effect of medroxyprogesterone acetate in the polycystic ovary syndrome, J Clin Endocrinol Metab 35:444-447, 1972.[Abstract/Free Full Text]
• Vittek, J.; Rappaport, S.C.; Gordon, G.G.; and Southren, A.L.: Cellular regulation of the metabolism of androgens in rat oral mucosa. I. Effect of medroxyprogesterone acetate (MPA) on the soluble supernatant (cytosol) activating microsomal testosterone Sa-reductase and 17β-oxidoreductase enzyme systems, J Dent Res 57:1016-1018, 1978.[Abstract/Free Full Text]
• Oshima, H.; and Ochiai, K.: On testicular 17β-hydroxysteroid oxidoreductase product activation of testosterone formation from androstenedione in vitro. Biochem Biophys Acta 306:227-236, 1973.[Medline] [Order article via Infotrieve]
• Oshima, H.; Paraska, L.; Yoshida, K.I.; and Troen, P.: Studies of the human testes. VIII. Product activation of 17β-hydroxysteroid oxidoreductase for testosterone, J Clin Endocrinol Metab 45:1097-1099, 1977.[Abstract/Free Full Text]
• Mulder, E.; Lamers-Stalhofen, G.J.M.; and van der Molen, H.J.: Isolation and characterization of 17β-hydroxysteroid dehydrogenase from human erythrocytes, Biochem J 127:649, 1972.[Medline] [Order article via Infotrieve]

Journal of Dental Research, Vol. 58, No. 2, 638-641 (1979)
DOI: 10.1177/00220345790580021801


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				R.-S. Ge, H.-B. Gao, V. L. Nacharaju, G. L. Gunsalus, and M. P. Hardy Identification of a Kinetically Distinct Activity of 11{beta}-Hydroxysteroid Dehydrogenase in Rat Leydig Cells Endocrinology, June 1, 1997; 138(6): 2435 - 2442. [Abstract] [Full Text] [PDF]

This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Vittek, J. Articles by Southren, A. L. Search for Related Content PubMed PubMed Citation Articles by Vittek, J. Articles by Southren, A. L. Social Bookmarking                         What's this?