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Journal of Dental Research
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The Effect of Vitamin A on Hamster Cheek Pouch Mucosa in Organ Culture

D. Mock

Faculty of Dentistry, University of Toronto, 124 Edward Street, Toronto, Ontario, Canada M5G 1 G6

J.H.P. Main

Faculty of Dentistry, University of Toronto, 124 Edward Street, Toronto, Ontario, Canada M5G 1 G6

Vitamin A was added to the medium of neonatal hamster cheek pouch mucosa maintained in organ culture. The epithelium of the treated explants showed a reduction in keratinization and down-growth into the underlying connective tissue. The cytological and morphological changes in the epithelium were consistent with glandular metaplasia.

REFERENCES

  • Domagk, G., and Von Dobeneck, P.: Uber Histologische Befunde bei der Ubordosierung wit Vitamina A Konzentrat. Archiv für Pathol Anatomie 290:383-395,1933.
  • Lawrence, D.J., and Bern, H.A.: Mucous Gland Formation in Keratinized Adult Epithelium in situ Treated with Vitamin A. Expt Cell Res. 21:443-446, 1960.
  • Lawrence, D.J.; Bern, H.A.; and Steadman, M.G.: Vitamin A and Keratinization. Studies on the Hamster Cheek Pouch. Ann Otol, Rhinol and Laryngol 69: 645-661, 1960.[Medline] [Order article via Infotrieve]
  • Bern, H.A.; and Lawrence, D.J.: Influence of Vitamin A on Keratinization, in Butcher, C. O., and Sognnaes, R. F. (ed): Fundamentals of Keratinization, Washington, D. C.: American Association for the Advancement of Science, 1962.
  • Wong, Y.C.: Mucous Metaplasia of the Hamster Cheek Pouch Epithelium under Hypervitaminosis A. Expt and Mol Path 23: 132-143,1975.
  • Fell, H.B.; and Mellanby, E.: Metaplasia Produced in Cultures of a Chick Ectoderm by High Vitamin A. J. Physiol 119: 470-488,1953.[Free Full Text]
  • Kahn,R.H.: Effect of Vitamin A and Estrogen on the Rat Vagina. Am J. Anat 75: 309-335,1954.
  • Lasnitzki, L.: The Effect of Carcinogens, Hormones and Vitamins on Organ Cultures. Int Rev Cytol 7:79-121, 1958.[CrossRef]
  • Szaba, G.: Cultivation of Skin, Pure Epidermal Sheets and Tooth Germs in vitro with a Note on the Effect of Vitamin A, in Butcher, C. 0., and Sognnaes, R. F. (ed): Fundamentals of Keratinization, Washington, D.C.: American Association for the Advancement of Science, 1962.
  • Marchok, A.C.; Cone, V.; and Net-Tesheim, R.: Induction of Squamous Metaplasia and Hypersecretory Activity in Tracheal Organ Cultures. Lab Invest 33:451-460, 1975.
  • Mock, D., and Main, J.H.P.: Long Term Organ Culture of Hamster Cheek Pouch Mucosa, J Oral Path 5:237-240, 1976.

Journal of Dental Research, Vol. 58, No. 2, 635-637 (1979)
DOI: 10.1177/00220345790580021701


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This Article
Right arrow Abstract Freely available
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Mock, D.
Right arrow Articles by Main, J.H.P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mock, D.
Right arrow Articles by Main, J.H.P.
Social Bookmarking
 Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?