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In vitro Testing of Plaque Control Agents

Department of Medicinal Chemistry, State University of New York at Buffalo, School of Pharmacy, Buffalo, New York

The development of a number of in vitro techniques for the evaluation of antiplaque effects of test agents has followed the characterization and culturing of plaque-forming microorganisms. Studies of the mechanism of action of chlorhexidine and clinical observations have assisted in defining critical aspects of these in vitro techniques. Such assays may play an increasingly important role in screening potential new agents as well as in the optimization of properties by chemical modification of new lead agents. In addition, data generated in the in vitro assay may assist the design of in vivo evaluations of new agents. Proper selection of in vitro techniques for these various functions in the preclinical development process may reduce the time and cost involved in the development of new antiplaque agents.

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Journal of Dental Research, Vol. 58, No. 12, 2396-2403 (1979)
DOI: 10.1177/00220345790580120904


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This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Coburn, R. A. Search for Related Content PubMed PubMed Citation Articles by Coburn, R. A. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Social Bookmarking                         What's this?