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Journal of Dental Research
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Comparison of the Plaque Microflora in Immunodeficient and Immunocompetent Dental Patients

Lee R. Brown

The University of Texas Dental Branch, Dental Science Institute, Houston, Texas 77025

Bruce F. Mackler

The University of Texas Dental Branch, Dental Science Institute, Houston, Texas 77025

Barnet M. Levy

The University of Texas Dental Branch, Dental Science Institute, Houston, Texas 77025

Thomas E. Wright

The University of Texas Dental Branch, Dental Science Institute, Houston, Texas 77025

Sandra F. Handler

The University of Texas Dental Branch, Dental Science Institute, Houston, Texas 77025

Joanne S. Moylan

The University of Texas Dental Branch, Dental Science Institute, Houston, Texas 77025

Deborah H. Perkins

The University of Texas Dental Branch, Dental Science Institute, Houston, Texas 77025

Harris J. Keene

The University of Texas Dental Branch, Dental Science Institute, Houston, Texas 77025

The nature and extent of the immune dysfunctions in 20 immunodeficient patients, as well as the immunocompetence of 22 control subjects, were verified by cell-mediated responsiveness and immunoglobulin quantitations. Comparisons of the microbial composition of supragingival plaque between the two populations showed that a greater number of immunodefcient than control subjects harbored Candida sp. and Staphylococcus sp. Conversely, a lower number of immunodeficient than control subjects harbored Streptococcus mutans. Also, patients with immune dysfunctions had a lower dental caries experience than their immunocompetent counterparts.

REFERENCES

  • Rosen, F.S.: Immunological Deficiency Disease, Clinical Immunobiology, Vol. 1, F. H. Bach and R. A. Good, eds. New York: Academic Press, 1972, pp. 271-289.
  • Ammann, A.J. and Wara, D.W.: Evaluation of Infants and Children with Recurrent Infection, Curr Prob Pedia 5:247, 1975.
  • Ammann, A.J. and Fudenberg, H.H.: Immunodeficiency Disease, Basic and Clinical Immunology, H. H. Fudenberg, D. P. Stiles, J. L. Caldwell and J. V. Wells, eds. Los Altos: Lange Medical Publications, 1976, pp. 333-359.
  • Horowitz, S.D. and Hong, R.: The Pathogenesis and Treatment of Immunodeficiency, Monographs in Allergy, Vol. 10, P. Kallos, T. M. Inderbitzin, Z. Trnka, A. L. deWeck and B. H. Waksmun, eds. New York: S. Karger, 1977, pp. 1-198.
  • Schur, P.H.; Borel, H.; Gelfand, E.W.; Alper, C.A.; and Rosen, F.S.: Selective Gamma-G Globulin Deficiencies in Patients with Recurrent Pyogenic Infections, New Eng J Med 283:631-634, 1970.[Medline] [Order article via Infotrieve]
  • Ammann, A.J. and Hong, R.: Selective IgA Deficiency: Presentation of 30 Cases and a Review of the Literature, Medicine 50: 223-236, 1971.[CrossRef][Medline] [Order article via Infotrieve]
  • Horowitz, S. and Hong, R.: Selective IgA Deficiency - Some Perspectives, Immunodeficiency in Man and Animals, D. Bergsma, R. A. Good, J. Finstad and N. W. Paul, eds. Sunderland: Sinauer Associates, Inc., 1975, pp. 129-133.
  • Schlegel, R.J.; Bernier, G.M.; Bellanti, J.A.; Maybee, D.A.; Osborne, G.B.; Stewart, J.L.; Pearl-Man, D.S.; Ouelette, J.; and Biehusen, F.: Severe Candidiasis Associated with Thymic Dysplasia, IgA Deficiency, and Plasma Antilymphocyte Effects, Pediatrics 45:926-936, 1970.[Abstract/Free Full Text]
  • Kirkpatrick, C.H.; Rich, R.R.; and Bennett, J.E.: Chronic Mucocutaneous Candidiasis: Model-building in Cellular Immunity, Ann Int Med 74:955-978, 1971.[Abstract/Free Full Text]
  • Provost, T.T.: Dermatologic Diseases, Basic and Clinical Immunology, H. H. Fudenberg, D. P. Stiles, J. L. Caldwell and J. V. Wells, eds. Los Altos: Lange Medical Publications, 1976, pp. 497-510.
  • Provost, T.: Infections Associated with T-cell Dysfunction, Infection and the Compromised Host, J. C. Allen, ed. Baltimore: Williams and Wilkins Co., 1976, pp. 49-80.
  • Hitzig, W.H.: Congenital Thymic and Lymphocytic Deficiency Disorders, Immunologic Disorders in Infants and Children, E. R. Stiehm and V. A. Fulginiti, eds. Philadelphia: W. B. Saunders Co., 1973, pp. 215-235.
  • Lehner, T.; Cardwell, J.E.; and Clarry, E.D.: Immunoglobulins in Saliva and Serum in Dental Caries, Lancet I:1294-1297,1967.
  • Robertson, P.B. and Cooper, M.D.: Oral Manifestations of IgA Deficiency, Adv Exp Med Biol 45:497-503, 1974.[Medline] [Order article via Infotrieve]
  • Cole, M.F.; Arnold, R.R.; Rhodes, M.J.; and McGhee, J.R.: Immune Dysfunction and Dental Caries. A Preliminary Report, J Dent Res 56:198-204, 1977.[Abstract/Free Full Text]
  • Robertson, P.B.; Wright, T.E., III; Mackler, B.F.; Lenertz, D.M.; and Levy, B.M.: Periodontal Status of Patients with Abnormalities of the Immune System, J Periodont Res 13:37-45, 1978.[CrossRef][Medline] [Order article via Infotrieve]
  • Robertson, P.B.; Mackler, B.F.; Wright, T.E.; and Levy, B.M.: Periodontal Status of Patients with Abnormalities of the Immune System. II. Observations over a Two-year Period. In Press J Periodontol.
  • Hersh, T.; Floch, M.H.; Binder, H.J.; Conn, H. 0.; Prizont, R.; and Spiro, H.M.: Disturbance of the Jejunal and Colonic Bacterial Flora in Immunoglobulin Deficiencies, Amer J Clin Nutr 23:1595-1601, 1970.[Medline] [Order article via Infotrieve]
  • Brown, W.R.; Savage, D.C.; Dubois, R.S.; Alp, M.H.; Mallory, A.; and Kern, F.; JR.: Intestinal Microflora of Immunoglobulin-deficient and Normal Human Subjects, Gastroenterology 62:1143-1152,1972.[Medline] [Order article via Infotrieve]
  • Brown, L.R.; Dreizen, S.; and Bodey, G.P.: Effect of Immunosuppression on the Human Oral Flora, Comparative Immunology of the Oral Cavity, S. E. Mergenhagen and H. W. Scherp, eds. Washington, D.C.: U.S. Government Printing Office, 1973, pp. 204-220.
  • Greenberg, M.S. and Cohen, G.: Oral Infection in Immunosuppressed Renal Transplant Patients, Oral Surg, Oral Med, Oral Path 43:879-885, 1977.[Medline] [Order article via Infotrieve]
  • Mackler, B.F.; Altman, L.C.; Rosen-Streich, D.L.; and Oppenheim, J.J.: Induction of Lymphokine Production by EAC and of Blastogenesis by Soluble Mitogens During Human B-cell Activation, Nature 249:834-837, 1974.[Medline] [Order article via Infotrieve]
  • Brown, L.R.; Dreizen, S.; Handler, S.; and Johnston, D.A.: Effect of Radiation-induced Xerostomia on Human Oral Microflora, J Dent Res 54:740-750, 1975.[Abstract/Free Full Text]
  • Freund, J.: Mathematical Statistics, Prentice Hall, 1962 (statistical programs available through Hewlett-Packard for the HP-97 Programmable Printing Calculator).
  • Brandtzaeg, P.; Fjellanger, I.; and Gjeruldson, S.T.: Immunoglobulin M: Local Synthesis and Selective Secretion in Patients with Immunoglobulin A Deficiency, Science 160:789-791, 1975.[CrossRef]
  • Arnold, R.R.; Cole, M.F.; Prince, S.; and McGhee, J.R.: Secretory IgM Antibodies to Streptococcus mutans in Subjects with Selective IgA Deficiency, Clin Immunol Immunopath 8:475-486, 1977.[CrossRef][Medline] [Order article via Infotrieve]

Journal of Dental Research, Vol. 58, No. 12, 2344-2352 (1979)
DOI: 10.1177/00220345790580120301
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[Abstract] [Full Text] [PDF]

This Article
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