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Radiochemical Determination of the Metabolic Activity of Collagen in Mature Dentin
J.M.P.M. Borggreven
Laboratory of Oral Biochemistry, School of Dentistry, University of Nijmegen, Nijmegen, The Netherlands
P.M.M. Hoppenbrouwers
Laboratory of Oral Biochemistry, School of Dentistry, University of Nijmegen, Nijmegen, The Netherlands
R. Gorissen
Laboratory of Oral Biochemistry, School of Dentistry, University of Nijmegen, Nijmegen, The Netherlands
Tritiated proline was administered to domestic cats during the development of their permanent premolars. The metabolic activity of collagen in the mature premolar dentin was determined by quantitating the amount of tritiated hydroxyproline in the dentin as a function of time. It has been demonstrated that the metabolic activity of the dentinal collagen was extremely low and remained within the experimental error for a period of 45 weeks.
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Journal of Dental Research, Vol. 58, No. 11,
2120-2124 (1979)
DOI: 10.1177/00220345790580111401

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