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Journal of Dental Research
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The Effect of Epinephrine on Pulpal Microcirculation

Solange Simard-Savoie

Department of Stomatology, Faculty of Dental Medicine, Université de Montréal, Montreal, Quebec

Helene Lemay

Department of Stomatology, Faculty of Dental Medicine, Université de Montréal, Montreal, Quebec

Larbi Taleb

Department of Stomatology, Faculty of Dental Medicine, Université de Montréal, Montreal, Quebec

The effect of epinephrine (Epi) on the microcirculation of the pulp and its neuropharmacological mechanism has been established, as well as the existence of alpha adrenergic receptors in the blood vessels of the pulp. In addition, our results showed that local injections of Epi at doses greater than 10-8 M produced an extreme drop in intrapulpal pressure (IPP). This effect was not obtained when Epi was injected intravenously.

REFERENCES

  • Weatherred, J.G.; Kroeger, D.C.; and Smith, E.L.: Pressure Response in the Dental Pulp Chamber to Superior Alveolar Nerve Stimulation, Fed Proc 22:756, 1963.
  • Kroeger, D.C.: Possible Role of Neuro-humoral Substances in the Pulp, In Finn, S. D. (ed.): Biology of Dental Pulp Organ: A Symposium, Univevsity of Alabama, University of Alabama Press, 1968, pp. 333-346.
  • Wynn, W.; Haldi, J.; Hopf, M.A.; and John, K.; Pressure Within the Pulp Chamber of the Dog's Tooth Relative to Arterial Blood Pressure, J Dent Res 42:1169-1177, 1963.[Free Full Text]
  • Sticht, F.D.: Some Factors Influencing Blood Pressure of Tooth Pulp, Am J Physiol 212:1421-1428, 1967.[Free Full Text]
  • Savoie, S. and Taleb, L.: Action de L'ardrén-aline sur la Microcirculation Pulpaire, J Canad Dent Assn 41:565-568, 1975.
  • Saunders, R. L. de C. H.: X-ray Microscopy of the Periodontal and Dental Pulp Vessels in the Monkey and in Man, Oral Surg 22-503-518, 1966.
  • Provenza, D.V.: The Blood Vascular Supply of the Dental Pulp with Emphasis on Capillary Circulation, Circulat Res 6:213-218, 1958.[Abstract/Free Full Text]
  • Trapp, L.D.; Goodson, J.M.; and Price, D.C.: The Effect of Local Anesthetic and Vasoconstrictors on Oral Submucosal Blood Flow in Beagle Dogs, AADR Prog and Abst 54:401, 1975.
  • Lemay-Laliberte, H.: Etude Physiopharmacologique du Tissu Pulpaire Chez le Chien. These MSc., Université de Montreal, Canada, 1972.

Journal of Dental Research, Vol. 58, No. 11, 2074-2079 (1979)
DOI: 10.1177/00220345790580110601


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T. Jima, J.Q. Zhang, T. Goto, T. Kondo, and T. Tanaka
A Scanning Electron Microscopic Study of the Contraction of Vascular Wall Cells in Dog Dental Pulp
Journal of Dental Research, November 1, 1991; 70(11): 1456 - 1461.
[Abstract] [PDF]


This Article
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