|
Sign In to gain access to subscriptions and/or personal tools.
|
Plasma and Developing Enamel Fluoride Concentrations During Chronic Acid-base Disturbances
Gary M. Whitford
Department of Oral Biology-Physiology, School of Dentistry, Medical College of Georgia, Augusta, Georgia 30912
Keith E. Reynolds
Department of Oral Biology-Physiology, School of Dentistry, Medical College of Georgia, Augusta, Georgia 30912
Mild acid-base disturbances were induced in rats for 30 days. These disturbances did not affect % ash of maxillary incisors or % P of the developing enamel from mandibular incisors. Total fluoride intake (food and water) among groups drinking fluoride-free water was constant. Nevertheless, average plasma and developing enamel fluoride concentrations were highest in the acidotic group and lowest in the alkalotic group. Among groups drinking water containing 50 ppm fluoride, total fluoride intake was highest by the alkalotic group and lowest by the acidotic group. Plasma and enamel fluoride concentrations, however, were highest in the acidotic group. It is concluded that plasma and developing enamel fluoride levels can be independent of, or inversely related to, fluoride intake.
REFERENCES
- Smith, F.A.; Gardner, D.E.; and Hodge, H.C.: Investigations on the Metabolism of Fluoride: II. Fluoride Content of Blood and Urine as a Function of the Fluorine in Drinking Water, J Dent Res 29:596-600, 1950.[Free Full Text]
- Shearer, T.R. and Suttie, J.W.: Effect of Fluoride Administration on Plasma Fluoride and Food Intake in the Rat, Am J Physiol 212:1165-1168, 1967.[Free Full Text]
- Guy, W.S.; Taves, D.R.; and Brey, W.S.: Organic Fluorocompounds in Human Plasma: Prevalence and Characterization. In: Biochemistry Involving Carbon- Fluorine Bonds (ed. Robert Fuller ), ACS Symposium Series, No. 28, pp 117-134, 1965.
- Ophaug, R.H. and Singer, L.: Influence of Variations in Fluoride Intake on the Ionic and Bound Fractions of Plasma and Muscle Fluoride, Proc Soc Exper Biol Med 155: 23-26, 1977.[CrossRef][Medline]
[Order article via Infotrieve]
- Ekstrand, J.: Relationship between Fluoride in the Drinking Water and the Plasma Fluoride Concentration in Man, Caries Res 12:123-127, 1978.[Medline]
[Order article via Infotrieve]
- Zipkin, I.; Mcclure, F.J.; Leone, N.C.; and Lee, W.A.: Fluoride Disposition in Human Bones After Prolonged Ingestion of Fluoride in Drinking Water, Pub Hlth Rept US 73:732-740, 1958.
- Smith, F.A.: Metabolism of Inorganic Fluoride. In: Handbook of Experimental Pharmacology, Pharmacology of Fluorides (ed. F. A. Smith), vol XX, Part I, New York: Springer-Verlag, 1966, pp. 107-117.
- Jackson, D. and Weidmann, S.M.: The Relationship Between Age and the Fluorine Content of Human Dentine and Enamel: A Regional Survey, Brit Dent J 107:303-306, 1959.
- Weatherell, J.A.; Deutsch, D.; Robinson, C.; and Hallsworth, A.S.: Assimilation of Fluoride by Enamel Throughout the Life of the Tooth, Caries Res 11 (Suppl 1): 85-115, 1977.[Medline]
[Order article via Infotrieve]
- Gedalia, I.; Brzezinski, N.; Portuguese, N.; and Bercovici, B.: The Fluoride Content of Teeth and Bone of Human Foetuses, Arch Oral Biol 9:331-340, 1964.[CrossRef]
- Zipkin, I. and Mcclure, F.J.: Deposition of Fluorine in the Teeth and Bones of the Growing Rat, J Nutr 47:611-629, 1952.[Abstract/Free Full Text]
- Suttie, J.W. and Phillips, P.H.: The Effect of Age on the Rate of Fluoride Deposition in the Femur of the Rat, Arch Biochem 83:355-359, 1959.
- Carlson, C.H.; Armstrong, W.D.; Singer, L.; and Hinshaw, L.B.: Renal Excretion of Radiofluoride in the Dog, Am J Physiol 198:829-832, 1960.[Abstract/Free Full Text]
- Chen, P.S., JR.; Smith, F.A.; Gardner, D.E.; O'Brien, J.A.; and Hodge, H.C.: Renal Clearance of Fluoride, Proc Soc Exper Biol Med 92:879-883, 1956.[CrossRef][Medline]
[Order article via Infotrieve]
- Walser, M.; and Rahill, W.J.: Renal Tubular Transport of Fluoride Compared with Chloride, Am J Physiol 210:1290-1292, 1966.[Free Full Text]
- Whitford, G.M.; Pashley, D.H.; and Stringer, G.I.: Fluoride Renal Clearance:a pH-dependent Event, Am J Physiol 230:527-532, 1976.[Abstract/Free Full Text]
- Harmon, C.; Whitford, G.M.; Pashley, D.H.; Reynolds, K.E.; and Stock, H.: pH-dependence of Fluoride Renal Clearance in Dogs, Soc Exper Biol Med (South-eastern Section): Abstract 13, 1976.
- Whitford, G.M. and Pashley, D.H.: The Effect of Body Fluid pH on Fluoride Distribution, Toxicity and Renal Clearance. In: Continuing Evaluation of the Use of Fluorides, Am Assoc Advan Sci Monograph, Selected Symposium 11, 187-221, 1979.
- Albright, F. and Reifenstein, F.G., JR.: In: The Parathyroid Glands and Metabolic Bone Disease, Baltimore. Williams and Wilkins Co., 1948, pp. 241-247.
- Barzel, U.S. and Jowsey, J.: The Effects of Chronic Acid and Alkali Administration on Bone Turnover in Adult Rats, Clin Sci 36:517-524, 1969.[Medline]
[Order article via Infotrieve]
- Weatherell, J.A.; Deutsch, D.; Robinson, C.; and Hallsworth, A.S.: Fluoride Concentrations in Developing Enamel, Nature, Lond. 256:230-232, 1975.[CrossRef][Medline]
[Order article via Infotrieve]
- Taves, D.R.: Determination of Submicromolar Concentrations of Fluoride in Biological Samples, Talanta 15:1015-1023, 1968.[CrossRef][Medline]
[Order article via Infotrieve]
- Chen, P.S., JR.; Toribara, T.Y.; and Warner, H.: Microdetermination of Phosphorus, Analyt Chem 28:1756-1758, 1956.
- Whitford, G.M.; Pashley, D.H.; and Reynolds, K.E.: Fluoride Absorption from the Rat Urinary Bladder: a pH-dependent Event, Am J Physiol 232:F10-F15, 1977.[Medline]
[Order article via Infotrieve]
- Whitford, G.M.; Schuster, G.S.; Pashley, D.H.; and Venkateswarlu, P.: Fluoride Uptake by Streptococcus mutans 6715, Infect Immun 18:680-687, 1977.[Abstract/Free Full Text]
- Reynolds, K.E.; Whitford, G.M.; and Pashley, D.H.: Acute Fluoride Toxicity: The Influence of Acid-Base Status, Toxicol Appl Pharmacol 45:415-427, 1978.[Medline]
[Order article via Infotrieve]
- Whitford, G.M.; Pashley, D.H.; and Reynolds, K.E.: Fluoride Tissue Distribution: Short Term Kinetics, Am J Physiol 236:F141-F149, 1979.[Medline]
[Order article via Infotrieve]
- Irvine, R.O.H.; Dow, J.; and Fong, J.: Effect of Anesthesia on the Collection of Blood for Acid-Base Studies in the Rat, Med Pharmacol Exp 14:557-562, 1966.
- Rollins, D.E.; Withrow, C.D.; and Woodbury, D.M.: Tissue Acid-Base Balance in Acetazolamide-Treated Rats, J Pharmacol Exptl Ther 174:535-540, 1970.[Abstract/Free Full Text]
- Shearer, T.R.; Kolstad, D.L.; and Suttie, J.W.: Bovine Dental Fluorosis: Histologic and Physical Characteristics, Am J Vet Res 39:597-602, 1978.
- Shinoda, H.: Effect of Long-Term Administration of Fluoride on Physico-Chemical Properties of Rat Incisor Enamel, Calcif Tiss Res 18:91-100, 1975.[CrossRef]
- Leatherwood, E.C.; Burnett, G.W.; Chandravejjsmarn, R.; and Sirikaya, P.: Dental Caries and Dental Fluorosis in Thailand, Am J Pub Hlth 55:1792-1799, 1965.
- Nanda, R.S.; Zipkin, I.; Doyle, J.; and Horowitz, H.S.: Factors Affecting the Prevalence of Dental Fluorosis in Lucknow, India, Arch Oral Biol 19:781-792,1974.[Medline]
[Order article via Infotrieve]
- Grahnen, H.; Lysell, L.; Myrberg, N.; and Ollinen, P.: Fluoride, Mineralization Defects of the Enamel, and Tooth Width, Acta Pediat Scand 63:188-192, 1974.
Journal of Dental Research, Vol. 58, No. 11,
2058-2065 (1979)
DOI: 10.1177/00220345790580110401
 CiteULike  Complore  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter What's this?
This article has been cited by other articles:
|
|
|
|
 
A.L.J.J. Bronckers, D.M. Lyaruu, and P.K. DenBesten
The Impact of Fluoride on Ameloblasts and the Mechanisms of Enamel Fluorosis
Journal of Dental Research,
October 1, 2009;
88(10):
877 - 893.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K.S. Prostak and Z. Skobe
Anion Translocation Through the Enamel Organ
Advances in Dental Research,
November 1, 1996;
10(2):
238 - 244.
[Abstract]
[PDF]
|
|
|
|
|
|
|
B. D. Gessner, M. Beller, J. P. Middaugh, and G. M. Whitford
Acute Fluoride Poisoning from a Public Water System
N. Engl. J. Med.,
January 13, 1994;
330(2):
95 - 99.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
K.S. Prostak, P. Seifert, and Z. Skobe
Serum Fluoride Level and Fluoride Content of Enameloid
Journal of Dental Research,
September 1, 1991;
70(9):
1266 - 1271.
[Abstract]
[PDF]
|
|
|
|
|
|
|
T. Aoba, E.C. Moreno, T. Tanabe, and M. Fukae
Effects of Fluoride on Matrix Proteins and Their Properties in Rat Secretory Enamel
Journal of Dental Research,
June 1, 1990;
69(6):
1248 - 1255.
[Abstract]
[PDF]
|
|
|
|
|
|
|
T. Aoba, J. Collins, and E.C. Moreno
Possible Function of Matrix Proteins in Fluoride Incorporation into Enamel Mineral during Porcine Amelogenesis
Journal of Dental Research,
July 1, 1989;
68(7):
1162 - 1168.
[Abstract]
[PDF]
|
|
|
|
|
|
|
J.W. Bawden, T.G. Deaton, G.G. Koch, and B.P. Crawford
Effect of an Acute Maternal Fluoride Dose on Fetal Plasma Fluoride Levels and Enamel Fluoride Uptake in Guinea Pigs
Journal of Dental Research,
July 1, 1989;
68(7):
1169 - 1172.
[Abstract]
[PDF]
|
|
|
|
|
|
|
J.W. Bawden, M.A. Keels, T.G. Deaton, and M.A. Crenshaw
The Ca, Pi, F, and Proline Content of Developing Bovine Enamel Under GBHA-stained and Unstained Bands
Journal of Dental Research,
June 1, 1988;
67(6):
938 - 941.
[Abstract]
[PDF]
|
|
|
|
|
|
|
R.A. Fridell, A. Lussi, M.A. Crenshaw, and J.W. Bawden
The in vitro Uptake of Fluoride by Secretory and Maturation Stage Bovine Enamel
Journal of Dental Research,
February 1, 1988;
67(2):
487 - 490.
[Abstract]
[PDF]
|
|
|
|
|
|
|
J.W. Bawden, T.G. Deaton, and M.A. Crenshaw
The Short-term Uptake and Retention of Fluoride in Developing Enamel and Bone
Journal of Dental Research,
October 1, 1987;
66(10):
1587 - 1590.
[Abstract]
[PDF]
|
|
|
|
|
|
|
J.W. Bawden, T.G. Deaton, and M.A. Crenshaw
Diffusion of Fluoride Through the Rat Enamel Organ in vitro
Journal of Dental Research,
August 1, 1987;
66(8):
1360 - 1363.
[Abstract]
[PDF]
|
|
|
|
|
|
|
C.R. Drinkard, T.G. Deaton, and J.W. Bawden
A Comparison of the Effects of Continuous and Periodic Fluoride Delivery on Fluoride Levels in Plasma, Enamel, and Bones of Nursing Rats
Journal of Dental Research,
January 1, 1987;
66(1):
19 - 22.
[Abstract]
[PDF]
|
|
|
|
|
|
|
P.R. Parker and J.W. Bawden
Prenatal Fluoride Exposure: Measurement of Plasma Levels and Enamel Uptake in the Guinea Pig
Journal of Dental Research,
November 1, 1986;
65(11):
1341 - 1345.
[Abstract]
[PDF]
|
|
|
|
|
|
|
P.K. Den Besten
Effects of Fluoride on Protein Secretion and Removal During Enamel Development in the Rat
Journal of Dental Research,
October 1, 1986;
65(10):
1272 - 1277.
[Abstract]
[PDF]
|
|
|
|
|
|
|
J.W. Bawden, P. McLean, and T.G. Deaton
Fluoride Uptake and Retention at Various Stages of Rat Molar Enamel Development
Journal of Dental Research,
January 1, 1986;
65(1):
34 - 38.
[Abstract]
[PDF]
|
|
|
|
|
|
|
C.R. Drinkard, T.G. Deaton, and J.W. Bawden
Enamel Fluoride in Nursing Rats with Mothers Drinking Water with High Fluoride Concentrations
Journal of Dental Research,
June 1, 1985;
64(6):
877 - 880.
[Abstract]
[PDF]
|
|
|
|
|
|
|
J.W. Bawden and M.A. Crenshaw
Effect of Inhibition of Net Calcium Uptake on Net Fluoride Uptake in Developing Rat Molars
Journal of Dental Research,
May 1, 1984;
63(5):
642 - 645.
[Abstract]
[PDF]
|
|
|
|
|
