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Journal of Dental Research
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Blood and Urinary 18F Pharmaco kinetics Following Parenteral Administration in the Rat

Gary M. Whitford

Departments of Oral Bioloay-Physiology and Physiology, Medical College of Georgia, Augusta, Georgia 30902, USA

Jimmy R. Patten

Departments of Oral Bioloay-Physiology and Physiology, Medical College of Georgia, Augusta, Georgia 30902, USA

Keith E. Reynolds

Departments of Oral Bioloay-Physiology and Physiology, Medical College of Georgia, Augusta, Georgia 30902, USA

David H. Pashley

Departments of Oral Bioloay-Physiology and Physiology, Medical College of Georgia, Augusta, Georgia 30902, USA

Blood and urinary excretion time courses of 18F administered parenterally to rats were monitored for two hours. The intraperitoneal, subcutaneous, and intravenous routes gave kinetically indistinguishable results after ten minutes following the dose. The blood time course during the first hour following intramuscular dosing showed a relative constancy and suggested a delayed absorption time.

REFERENCES

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  • Whitford, G.M., and Pashley, D.H.: Soft Tissue Distribution of Fluoride, J Dent Res 53: Special Issue, 231 (abstract), 1974.
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  • Mccann, H.G.: The Solubility of Fluor-apatite and Its Relationship to that of Calcium Fluoride, Arch Oral Biol 13:987-1001, 1968.[CrossRef][Medline] [Order article via Infotrieve]

Journal of Dental Research, Vol. 56, No. 7, 858-861 (1977)
DOI: 10.1177/00220345770560072301


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G. M. Whitford, J. Ekstrand, R. S. Callan, and D. E. Pearson
Subcutaneously Implanted Alginate as a Continuous-release Source of Fluoride
Journal of Dental Research, February 1, 1980; 59(2): 186 - 191.
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This Article
Right arrow Abstract Freely available
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
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Citing Articles
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Google Scholar
Right arrow Articles by Whitford, G. M.
Right arrow Articles by Pashley, D. H.
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PubMed
Right arrow PubMed Citation
Right arrow Articles by Whitford, G. M.
Right arrow Articles by Pashley, D. H.
Right arrowPubmed/NCBI databases
*Compound via MeSH
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Hazardous Substances DB
*FLUORINE
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