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Blood and Urinary 18F Pharmaco kinetics Following Parenteral Administration in the Rat
Gary M. Whitford
Departments of Oral Bioloay-Physiology and Physiology, Medical College of Georgia, Augusta, Georgia 30902, USA
Jimmy R. Patten
Departments of Oral Bioloay-Physiology and Physiology, Medical College of Georgia, Augusta, Georgia 30902, USA
Keith E. Reynolds
Departments of Oral Bioloay-Physiology and Physiology, Medical College of Georgia, Augusta, Georgia 30902, USA
David H. Pashley
Departments of Oral Bioloay-Physiology and Physiology, Medical College of Georgia, Augusta, Georgia 30902, USA
Blood and urinary excretion time courses of 18F administered parenterally to rats were monitored for two hours. The intraperitoneal, subcutaneous, and intravenous routes gave kinetically indistinguishable results after ten minutes following the dose. The blood time course during the first hour following intramuscular dosing showed a relative constancy and suggested a delayed absorption time.
REFERENCES
- Smith, F.A.: Handbook of Experimental Pharmacology: Pharmacology of Fluoride, Part I, New York, Springer-Verlag, pp 56-58, 1966.
- Stookey, G.K.: Fluoride and Human Health, Geneva, World Health Organization, pp 40-56, 1970.
- Shearer, T.R.: Comparative Metabolic Responses of Rat Kidney and Liver to Acute Doses of Fluoride, Proc Soc Exper Biol Med. 146:209-212, 1974.[CrossRef][Medline]
[Order article via Infotrieve]
- Taylor, J.M.; Scott, J.K.; Maynard, E.A.; Smith, F.A.; and Hodge, H.C.: Toxic Effects of Fluoride on the Rat Kidney: Acute Injury from Single Large Doses, Tox Appl Pharm 3:278-289, 1961.[CrossRef][Medline]
[Order article via Infotrieve]
- Tobin, T.; Akera, T.: DWORIN, J.Z.; and BRoDY, T.M.: Fluoride Nephropathy: Lack of Direct Involvement of Renal ATPase, Canad J Physiol 52:489-495, 1974.
- Wallace-Durbin, P.: Metabolism of Fluorine in the Rat Using 18F as a Tracer, J Dent Res 33:789-800, 1954.
- Carlson, C.H.; Singer, L.; and Arm-Strong, W.D.: Radiofluoride Distribution in Tissues of Normal and Nephrectomized Rats, Proc Soc Exper Biol Med 103:418-420, 1960.[CrossRef][Medline]
[Order article via Infotrieve]
- Whitford, G.M., and Pashley, D.H.: Soft Tissue Distribution of Fluoride, J Dent Res 53: Special Issue, 231 (abstract), 1974.
- Crone, C.: The Inflammatory Process, vol. II, 2nd ed, New York: Academic Press, Chap. 3, 1973.
- Rodbard, S.: Selective Staining of Fibrous Connective Tissue Capsules and Lymphatics, Lymphology 8: 142-148, 1975.[Medline]
[Order article via Infotrieve]
- Fuchs, F.: Striated Muscle, Annual Rev Physiol 36:461-502, 1974.[CrossRef][Medline]
[Order article via Infotrieve]
- Mccann, H.G.: The Solubility of Fluor-apatite and Its Relationship to that of Calcium Fluoride, Arch Oral Biol 13:987-1001, 1968.[CrossRef][Medline]
[Order article via Infotrieve]
Journal of Dental Research, Vol. 56, No. 7,
858-861 (1977)
DOI: 10.1177/00220345770560072301

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G. M. Whitford, J. Ekstrand, R. S. Callan, and D. E. Pearson
Subcutaneously Implanted Alginate as a Continuous-release Source of Fluoride
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