This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Donlon, W. C. Search for Related Content PubMed PubMed Citation Articles by Donlon, W. C. Social Bookmarking                         What's this?

Immune Neutrality of Calf Skin Collagen Gel Used to Stimulate Revitalization in Pulpless Open Apex Teeth of Rhesus Monkeys

Department of Biology, Hofstra University, Hempstead, New York 11550, USA

A collagen mineral gel has recently been shown to stimulate revitalization of pulpless open apex teeth when syringed into debrided root canals. Experiments were conducted to examine possible stimulation of the immune system by the experimental procedure. Ring tests (interface precipitation analysis), Ouchterlony plates and hemagglutination tests on plasma samples taken from experimental rhesus monkeys throughout the healing process indicate a complete lack of humoral immune responsiveness to the injected collagen.

REFERENCES

• Nevins, A.; Finkelstein, F.; Borden, B.G.; and Moodnik, R.: Formation of Mineralized Scar Tissue Induced by Implants Containing Collagen-Calcium Phosphate Gel, J Endodont 1:303-309, 1975.[CrossRef][Medline] [Order article via Infotrieve]
• Rothbard, S., and Watson, R.F.: Immunologic Relations among Various Animal Collagens, J Exp Med 122:231-237, 1965.
• Schmitt, F.O.; Levine, L.; Drake, M.P.; Rubin, A.L.; Pfahl, D.; and Davidson, P.F.: The Antigenicity of Tropocollagen, Proc Nat Acad Sci USA 51:493-497, 1964.[Free Full Text]
• Seltzer, S.: Endodontology, New York: Blakiston Division, McGraw-Hill, 1971, 455-461.
• Traub, W., and Piez, K.A.: The Chemistry and Structure of Collagen, Adv Protein Chem 25:243-352, 1971.[Medline] [Order article via Infotrieve]
• Nimni, M.E.: Metabolic Pathways and Control Mechanisms Involved in the Biosynthesis and Turnover of Collagen in Normal and Pathological Connective Tissues, J Oral Path 2:175-202, 1973.[CrossRef][Medline] [Order article via Infotrieve]
• Leroy, E.C.: Some Characteristics of the Antigenic Moiety of Calfskin Collagen, J Immunol 102:919-924, 1969.[Abstract/Free Full Text]
• Timpl, R.; Wolff, R.; Wick, G.; Furthmayr, H.; and Steffen, C.: Immunogenicity and Specificity of Collagen. VII. Differences between Various Collagens Demonstrated by Cross-reaction Studies, J Immunol 101:725-729, 1968.[Abstract/Free Full Text]
• Rauterberg, J.; Timpl, R.; and Furthmayr, H.: Structural Characterization of N-Terminal Antigenic Determinants in Calf and Human Collagen, Eur J Biochem 27:231-237, 1972.[CrossRef][Medline] [Order article via Infotrieve]
• Maoz, A.; Fuchs, S.; and Michaeli, D.: Ascaris Cuticle Collagen: On the Antigenic Specificity of the Subunits, Biochim Biophys Acta 243:106-110, 1971.[Medline] [Order article via Infotrieve]
• Borek, W.; Kurtz, J.; and Sela, M.: Immunological Properties of a Collagen-like Synthetic Polypeptide, Biochim Biophys Acta 243:106-110, 1969.
• Beil, W.; Furthmayr, R.; and Timpl, R.: Chicken Antibodies to Soluble Rat Collagen. I. Characterization of the Immune Response by Precipitation and Agglutination Methods, Immunochem 9:779-788, 1972.[CrossRef][Medline] [Order article via Infotrieve]
• Chidlow, J.W.; Bourne, F.J.; and Bailey, A.J.: Production of Hyperimmune Serum against Collagen and Its Use for the Isolation of Specific Collagen Peptides on Immunosorbent Columns, FEBS Lett 41:248-252, 1974.[CrossRef][Medline] [Order article via Infotrieve]
• Click, E.M., and Bornstein, P.: Isolation and Characterization of the Cyanogen Bromide Peptides from the 1 and 2 Chains of Human Skin Collagen, Biochemistry 9: 4699-4706,1970.[CrossRef][Medline] [Order article via Infotrieve]
• Matthews, M.B.: Molecular Evolution of Connective Tissue, in Biology of the Mouth (Symposium, Dec 1966, Washington, D.C.), Person, P. (ed), AAAS Publication No. 89, pp 199-236, 1968.
• Timpl, R.; Wolff, I.; Meigel, W.; Pontz, B.; Steffen, C.; and Kuhn, K.: Antigenic Properties of Chemically Modified Collagen, J Immunol 105:1131-1137, 1970.[Abstract/Free Full Text]
• Pikkarainen, J.; Rantanen, J.; and Kulonen, E.: On the Comparative Biochemistry of Collagen, in Biochemie et Physiologie du Tissu Conjunctif (Symposium 1965, Lyon) Comte, P. (ed), Societe Orineco et Imprimerie du Sud-Est Lyon, Lyon, France, pp 303-312, 1966.
• Campbell, D.H.; Garvey, J.S.; Cremer, N.E.; and Sussdorf, D.H.: Methods in Immunology, 2nd ed, Reading, Mass., W.A. Benjamin, Inc., pp 236-241, 250-259, 271-291, 1970.
• Chase, M.W.: Buffers, in Methods in Immunology and Immunochemistry, Vol. II, Williams, C.A. and Chase, M.W. (eds), New York, Academic Press, pp 365-407, 1968.
• Munoz, J.: Double Diffusion in Plates, in Methods in Immunology and Immunochemistry, Vol. III, Williams, C. and Chase, M. (eds), New York, Academic Press, pp 146-160, 1971.
• Heremans, J.F.: Antigen Titration by Simple Radial Immunodiffusion in Plates, in Methods in Immunology and Immunochemistry, Vol. II, Williams, C. and Chase, M. eds), New York, Academic Press, pp. 213-224, 1971.
• Droege, W.: Thymocyte Subpopulation with Suppressive Activity, in The Immune System, Genes, Receptors, Signals, Sercarz, E.E.; Williamson, A.R.; and Fox, C.F. (eds), New York, Academic Press, pp 431-446,1974.
• Weigle, W.O.: Cyclical Production of Antibody as a Regulatory Mechanism in the Immune Response, in Advances in Immunology, Vol. 21, Dixon, F.J. and Kunkel, H.G. (eds.), New York, Academic Press, pp 87-111, 1975.
• Spirescu, I.: Application of Asseous-Dental Homografts to Monkeys and Men, in Medical Primatology, Proceedings of the 3rd Conference on Experimental Medicine and Surgery of Primates, Lyon, Part II, Munich, Karger-Basel, pp 212-216, 1972.
• Narang, R., and Wells, H.: Experimental Osteogenesis in Periapical Areas with Decalcified Allogenic Bone Matrix, Oral Surg 35:136, Jan 1973.[CrossRef][Medline] [Order article via Infotrieve]
• Shulman, L.B.: The Transplantation Antigenicity of Tooth Homografts, Oral Surg 17:389, 1964.[CrossRef][Medline] [Order article via Infotrieve]

Journal of Dental Research, Vol. 56, No. 6, 670-673 (1977)
DOI: 10.1177/00220345770560061701


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Donlon, W. C. Search for Related Content PubMed PubMed Citation Articles by Donlon, W. C. Social Bookmarking                         What's this?