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Comparison of Antiplaque Agents Using an In Vitro Assay Reflecting Oral Conditions

Department of Oral Biology, School of Dentistry, Department of Medicinal Chemistry, School of Pharmacy, State University of New York at Buffalo, Buffalo, New York 14226, USA

P.J. Baker

Department of Oral Biology, School of Dentistry, Department of Medicinal Chemistry, School of Pharmacy, State University of New York at Buffalo, Buffalo, New York 14226, USA

R.A. Coburn

Department of Oral Biology, School of Dentistry, Department of Medicinal Chemistry, School of Pharmacy, State University of New York at Buffalo, Buffalo, New York 14226, USA

R.J. Genco

Department of Oral Biology, School of Dentistry, Department of Medicinal Chemistry, School of Pharmacy, State University of New York at Buffalo, Buffalo, New York 14226, USA

An in vitro assay is described using saliva-treated bovine enamel slabs for determining the potential of chemotherapeutic agents to adsorb to tooth surfaces and act against plaque-forming bacteria. Chlorhexidine was found to inhibit the formation of in vitro plaque by Actinomyces viscosus, A naeslundii, Streptococcus mutans and S sanguis. Actinobolin was found to have marked antibacterial properties but limited adsorptive qualities.

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Journal of Dental Research, Vol. 56, No. 6, 559-567 (1977)
DOI: 10.1177/00220345770560060201


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