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Detection of Functional Complement Components in Gingival Crevicular Fluid from Humans with Periodontal Disease

Dental Research Center, University of North Carolina, Chapel Hill, North Carolina 27514, USA

Robert J. Boackle

Dental Research Center, University of North Carolina, Chapel Hill, North Carolina 27514, USA

H. Hugh Fudenberg

Dental Research Center, University of North Carolina, Chapel Hill, North Carolina 27514, USA

Myron S. Silverman

Dental Research Center, University of North Carolina, Chapel Hill, North Carolina 27514, USA

Crevicular fluid was collected from patients with periodontitis and tested for the presence of a functional complement system. The effect of dental plaque on the first complement component (C1) was studied. Results indicated functional C1 and functional whole complement activities in gingival crevicular fluid are rapidly inactivated by dental plaque and possibly other host factors.

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Journal of Dental Research, Vol. 56, No. 3, 327-331 (1977)
DOI: 10.1177/00220345770560032001


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