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Lidocaine's Influence on the Accumulation and Depletion Rates of Mouse Brain Amines

Department of Pharmacology-Physiology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA

James W. Smudski

Department of Pharmacology-Physiology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA

Mouse brain was analyzed for serotonin, norepinephrine, and dopamine. Pargyline plus lidocaine treatment caused an increased accumulation rate of serotonin over one hour compared to pargyline controls. Methyl-p-tyrosine plus lidocaine treatment caused a decreased depletion rate of dopamine over four hours compared to rates of methyl-p-tyrosine controls, and no difference for norepinephrine.

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Journal of Dental Research, Vol. 56, No. 11, 1391-1394 (1977)
DOI: 10.1177/00220345770560111901


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This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Ciarlone, A. E. Articles by Smudski, J. W. Search for Related Content PubMed PubMed Citation Articles by Ciarlone, A. E. Articles by Smudski, J. W. Social Bookmarking                         What's this?