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The Merkel Cell in Oral Human Mucosa
Gene J. Fortman
Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55901, USA
R.K. Winkelmann
Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55901, USA
A study of the mucosal Merkel cells from 10 patients showed that the cell contained an intranuclear rodlet, clear cell qualities, fine desmosomes, characteristic membrane-bound Merkel granules, and cellular "horns" and had a close relationship to terminal axons. The Merkel cell is an intraepithelial cell with features of neurons and of amine-storage cells.
REFERENCES
- Merkel, F.: Tastzellen und Tastkorperchen bei den Hausthieren und biem Menschen, Arch Microbiol Anat 11: 636-652, 1875.[CrossRef]
- Merkel, F.S.: Ueber die Endigungen der sensiblen Nerven in der Haut der Wirbelthiere, Rostock: H. Schmidt, 1880.
- WINKELMANN, R.K.: Nerve Endings in Normal and Pathologic Skin: Contributions to the Anatomy of Sensation, Springfield, Ill.; Charles C Thomas, Publisher, 1960. 4. IGGO, A., and MuIR, A.R.: The Structure and Function of a Slowly Adapting Touch Corpuscle in Hairy Skin, J Physiol (Paris) 200:763-796, 1969.
- Winkelmann, R.K., and Breathnach, A.S.: The Merkel Cell, J Invest Dermatol 60:2-15, 1973.[CrossRef][Medline]
[Order article via Infotrieve]
- Fortman, G.J.: Ultrastructure of the Merkel Cell in Human Oral Mucosa, Thesis,
- Mayo Graduate School of Medicine (University of Minnesota), Rochester, 1974.
- Nikai, H.; Rose, G.G.; and Cattoni, M.: Merkel Cell in Human and Rat Gingiva, Arch Oral Biol 16:835-843, 1971.[CrossRef][Medline]
[Order article via Infotrieve]
- Hashimoto, K.: The Fine Structure of the Merkel Cell in Human Oral Mucosa, J Invest Dermatol 58:381-387, 1972.[CrossRef][Medline]
[Order article via Infotrieve]
- Suzuki, H., and Kurosumi, K.: Fine Structure of the Cutaneous Nerve Endings in the Mole Snout, Arch Histol Jap 34:35-50, 1972.[Medline]
[Order article via Infotrieve]
- Smith, K.R., JR.: The Ultrastructure of the Haarscheibe and Merkel Cell, J Invest Dermatol 54:150-159, 1970.[CrossRef][Medline]
[Order article via Infotrieve]
- Saxod, R.: Etude au microscope electronique de l'histogenese du corpuscle sensoriel cutane de Grandry chez le Canard, J Ultrastruct Res 32:477-496, 1970.[CrossRef][Medline]
[Order article via Infotrieve]
- Andres, K.H.: Uber die Feinstruktur der Reszeptoren an Sinushaaren, Z Zellforsch Mikr Anat 75:339-365, 1966.[CrossRef][Medline]
[Order article via Infotrieve]
- Halata, Z.: Zu den Nervenendigungen (Mirkelsche Endigungen) in der Haarlosen Nasenhaut der Katze, Z Zellforsch Mikr Anat 106:51-60, 1970.[CrossRef][Medline]
[Order article via Infotrieve]
- Lyne, A.G., and Hollis, D.E.: Merkel Cells in Sheep Epidermis During Fetal Development, J Ultrastruct Res 34:464-472, 1971. 15. PEDERSON, G.T., and WINKELMANN, R.K.: Unpublished data.[CrossRef][Medline]
[Order article via Infotrieve]
- Mustakallio, K.K., and Kiistala, U.: Electron Microscopy of Merkel's "Tastzelle," a Potential Monoamine Storing Cell of Human Epidermis, Acta Derm Venereol (Stockh) 47:323-326, 1967.[Medline]
[Order article via Infotrieve]
- Fortman, G.J., and Winkelmann, R.K.: A Merkel Cell Nuclear Inclusion, J Invest Dermatol 61:334-338, 1973.[CrossRef][Medline]
[Order article via Infotrieve]
- Straile, W.E.; Tipnis, U.R.; Mann, S.J.; and Clark, W.H., JR.: Lattice and Rodlet Nuclear Inclusions in Merkel Cell in Rabbit Epidermis, J Invest Dermatol 64:178-183, 1975.[CrossRef][Medline]
[Order article via Infotrieve]
- Brody, I.: The Ultrastructure of the Epidermis in Psoriasis Vulgaris as Revealed by Electron Microscopy, J Ultrastruct Res 6: 304-367, 1962.[CrossRef][Medline]
[Order article via Infotrieve]
- Watson, M.L.: Observations on a Granule Associated with Chromatin in the Nuclei of Cells of Rat and Mouse, J Cell Biol 13:162-167, 1962.[Free Full Text]
- Weber, A.F.; Whipp, S.C.; and Usenik, E.A.: Studies of the Occurrence, Ultrastructure, and Physiological Significance of the Nuclear Body in the Ox (abstract), J Cell Biol 19:73A, 1963.
- Weber, A.F., and Frommes, S.P.: Nuclear Bodies: Their Prevalence, Location, and Ultrastructure in the Calf, Science 141:912-913, 1963.[Abstract/Free Full Text]
- Jones, A.L., and Fawcett, D.W.: Hypertrophy of the Agranular Endoplasmic Reticulum in Hamster Liver Induced by Phenobarbital, J Histochem Cytochem 14:215-232, 1966.[Abstract]
- Horstmann, E.; Richter, R.; and Roosen-Runge, E.: Zur Elektronenmikroskopie der Kerneinschlüsse im Menschlichen Nebenhodenepithel, Z Zellforsch Mikr Anat 69: 69-79, 1966.[CrossRef][Medline]
[Order article via Infotrieve]
- Krishan, A.; Uzman, B.G.; and Healey-Whyte, E.T.: Nuclear Bodies: A Component of Cell Nuclei in Hamster Tissues and Human Tumors, J Ultrastruct Res 19:563-572, 1967.[CrossRef][Medline]
[Order article via Infotrieve]
- ROBERTSON, D.M., and MACLEAN, J.D.: Nuclear Inclusions in Malignant Gliomas, Arch Neurol (Chicago) 13:287-296, 1965. 27. ROBERTSON, D.M.: Electron Microscopic Studies of Nuclear Inclusions in Meningiomas, Am J Pathol 45:835-848, 1964.
- Tani, E.; Ametani, T.; Kawamura, Y.; and Handa, H.: Nuclear Structures of Primary Malignant Lymphoma in the Brain, Cancer 24:617-624, 1969.[CrossRef][Medline]
[Order article via Infotrieve]
- Bernhard, W., and Granboulan, N.: The Fine Structure of the Cancer Cell Nucleus, Exp Cell Res Suppl 9:19-53, 1963.[CrossRef]
- Bencosme, S.A.; Allen, R.A.; and Latta, H.: Functioning Pancreatic Islet Cell Tumors Studied Electron Microscopically, Am J Pathol 42:1-21, 1963.[Medline]
[Order article via Infotrieve]
- Willey, T.J., and Schultz, R.L.: Intranuclear Inclusions in Neurons of the Cat Primary Olfactory System, Brain Res 29:31-45, 1971.[CrossRef][Medline]
[Order article via Infotrieve]
- Chandler, R.L.: Intranuclear Structures in Neurons, Nature 209:1260-1261, 1966.[Medline]
[Order article via Infotrieve]
- CoLONNIER, M.: On the Nature of Intranuclear Rods, J Cell Biol 25:646-653, 1965. 34. KIM, S.U.; MASUROVSKY, E.B.; BENITEZ, H.H.; and MURRAY, M.R.: Histochemical Studies of the Intranuclear Rodlet in Neurons of Chicken Sympathetic and Sensory Ganglia, Histochemistry 24:33-40, 1970. 35. MASUROVSKY, E.B.; BENITEZ, H.H.; KiM, S.U.; and MURRAY, M.R.: Origin, Development, and Nature of Intranuclear Rodlets and Associated Bodies in Chicken Sympathetic Neurons, J Cell Biol 44:172-191, 1970.
Journal of Dental Research, Vol. 56, No. 11,
1303-1312 (1977)
DOI: 10.1177/00220345770560110201

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