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Studies on Hypoxia: XII. Detrimental Effects of Synthetic Polyribonucleotides on Epiphyseal Plates of Rats Exposed to Hypoxia

Department of Oral Biology, University of Michigan, Ann Arbor, Michigan 48104, USA

M.K. Kim

Department of Anatomy, University of Michigan, Ann Arbor, Michigan 48104, USA

S.S. Han

Program in Biology of Aging, University of Michigan, Ann Arbor, Michigan 48104, USA

The effect of different doses of polyadenylic and polyuridylic acids (poly A:U) was studied in control rats and in rats exposed to hypoxia. In the control rats, administration of different doses of poly A:U did not change the thickness of the epiphyseal plate or increase the incorporation of ³H-phenylalanine as judged using radioautography. Rats exposed to hypoxia showed a significant dose-related reduction in the thickness of the epiphyseal plate and ³H-phenylalanine incorporation.

REFERENCES

• Han, S.S.; Koo, C.S.; and Kim, M.K.: Studies on Hypoxia: XI. Long-term Effects on the Epiphyseal Plate-A Histometric and Radio-autographic Study, J Dent Res 55: 367-371, 1976.[Abstract/Free Full Text]
• Kim, Y.G.: Effects of Hypoxia and Polynucleotides upon the Rat Pancreas: An Electron Microscopic and Biochemical Study, PhD thesis, University of Michigan, 1974.
• Braun, W., and Nakano, M.: Antibody Formation: Stimulation by Polyadenylic and Polycytidylic Acids, Science 157: 819-821, 1967.[Abstract/Free Full Text]
• Braun, W.; Ishizuka, M.; Yajima, Y.; Webb, D.; and Winchurch, R.: Spectrum and Mode of Action of Poly A:U in the Stimulation of Immune Responses, in Beer, R., and Braun, W. (eds): Biological Effects of Polynucleotides, New York: Springer-Verlag, 1971, pp 139-156.
• Chess, L.; Levy, C.; Schmukler, M.; Smith, K.; and Mardiney, M.R., JR.: The Effect of Synthetic Polynucleotides on Immunologically Induced Tritiated Thymidine Incorporation: Amplification of Response, Transplantation 14: 748-755, 1972.
• Cone, R.G., and Johnson, A.G.: Regulation of the Immune System by Synthetic Polynucleotides: IV. Amplification of Proliferation of Thymus-Influenced Lymphocytes, Cell Immunol 3: 283-293, 1972.[CrossRef][Medline] [Order article via Infotrieve]
• Cone, R.G., and Johnson, A.G.: Regulation of the Immune System by Synthetic Polynucleotides: III. Action on Antigen-Reactive Cells of Thymic Origin, J Exp Med 133: 665-676, 1971.[Abstract/Free Full Text]
• Colby, C., JR.: The Induction of Interferon by Natural and Synthetic Polynucleotides, in: Davidson, J.N., and Cohn, W.E. (eds): Progress in Nucleic Acid Research and Molecular Biology, Vol II, New York: Academic Press, Inc., 1971, pp 1-32.
• Johnson, H.G., and Johnson, A.G.: Regulation of the Immune System by Synthetic Polynucleotides: II. Action on Peritoneal Exudate Cells, J Exp Med 1322: 649-664, 1971.
• Schmidtke, J.R., and Johnson, A.T.: Regulation of the Immune System by Synthetic Polyribonucleotides I. Characteristics of Adjuvant Action on Antibody Synthesis, J Immunol 106: 1191-1200, 1971.
• Johnson, A.G.; Schmidtke, J.R.; Merritt, K.; and Han, I.H.: Enhancement of Antibody Formation by Nucleic Acids and Their Derivatives, in Plescia, O.J., and Braun, W. (eds): Nucleic Acids in Immunology, New York: Springer-Verlag, 1968, pp 379-385.
• Kim, Y.G., and Han, S.S.: Studies on Hypoxia: X. Effects of Synthetic Polyribonucleotides on Pancreata from Hypoxic and Control Rats, an Electron Microscopic and Biochemical Study, Exp Mol Pathol 23: 43-58, 1975.[Medline] [Order article via Infotrieve]
• Han, S.S.; Hwang, L.; and Cho, M.I.: Enhancement of Functional Recovery by Polynucleotides in Fluorouracil-Treated Rat Parotid, J Dent Res (Special Issue A): Abstract No. 391, 1975.
• Schell, P.L.: Uptake of Polynucleotides by Intact Mammalian Cells: VIII. Synthetic Homoribopolynucleotides, Biochim Biophys Acta 240: 472-484, 1971.[Medline] [Order article via Infotrieve]
• Schell, P.L.: Uptake of Polynucleotides by Intact Mammalian Cells: XI. pH-Dependent Permeability Changes for Synthetic Ribopolymers, Biochim Biophys Acta 262: 467-475, 1972.[Medline] [Order article via Infotrieve]
• Johnson, A.G.: Personal communication, 1975.

Journal of Dental Research, Vol. 55, No. 4, 643-647 (1976)
DOI: 10.1177/00220345760550041701


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This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Koo, C.S. Articles by Han, S.S. Search for Related Content PubMed PubMed Citation Articles by Koo, C.S. Articles by Han, S.S. Social Bookmarking                         What's this?