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Journal of Dental Research
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Effects of Anti-Inflammatory Steroids on Mouse Embryonic Movements During Palatal Development

Bruce E. Walker

Department of Anatomy, Michigan State University, East Lansing, Michigan 48824, USA

Joan Quarles

Department of Anatomy, Michigan State University, East Lansing, Michigan 48824, USA

The frequency of spontaneous embryonic muscular movements was recorded for embryos from mice treated with cortisone or triamcinolone. Movement was significantly reduced in A/J strain mouse embryos exposed to these anti-inflammatory agents. Cleft palates induced by the drugs may originate from failure of the embryonic tongue to be withdrawn from between the palatine shelves.

REFERENCES

  • Walker, B.E.: Correlation of Embryonic Movement with Palate Closure in Mice, Teratology 2: 191-198, 1969.[Medline] [Order article via Infotrieve]
  • Humphrey, T.: The Relation Between Human Fetal Mouth Opening Reflexes and Closure of the Palate, Am J Anat 125: 317-344, 1969.[Medline] [Order article via Infotrieve]
  • Wragg, L.E.; Smith, J.A.; and Borden, C.S.: Myoneural Maturation and Function of the Foetal Rat Tongue at the Time of Secondary Palate Closure, Arch Oral Biol 17: 673-782, 1972.[Medline] [Order article via Infotrieve]
  • Walker, B.E.: Induction of Cleft Palate in Rats with Anti-Inflammatory Drugs. Teratology 4: 39-42, 1971.[CrossRef][Medline] [Order article via Infotrieve]
  • Walker, B.E.: Effect of Triamcinolone on Spontaneous Embryonic Movements, abstracted, IADR Program and Abstracts of Papers, No. 183, 1971.
  • Fraser, F.C., and Fainstat, T.D.: Production of Congenital Defects on the Offspring of Pregnant Mice Treated with Cortisone, Pediatrics 8: 527-533, 1951.[Abstract/Free Full Text]
  • Walker, B.E.: Cleft Palate Produced in Mice by Human Equivalent Dosage with Triamcinolone, Science 149: 862-863, 1965.[Abstract/Free Full Text]
  • Walker, B.E.: Correlation of Embryonic Movement with Palate Development, abstracted, Teratology 5: 268, 1972.
  • Fraser, F.C.; Kalter, H.; Walker, B.E.; and Fainstat, T.D.: The Experimental Production of Cleft Palate with Cortisone and Other Hormones, J Cell Comp Physiol 43: 237-259, 1954.[CrossRef]
  • Kalter, H.: The Inheritance of Susceptibility to the Teratogenic Action of Cortisone in Mice, Genetics 39: 185-196, 1954.[Free Full Text]
  • Trasler, D.G.: Strain Differences in Susceptibility to Tertaogenesis: Survey of Spontaneously Occurring Malformations in Mice, in Wilson, J.G., and Warkany, J. (eds): Teratology, Principles and Techniques, Chicago: University of Chicago Press, 1965, pp 38-55.
  • Snell, G.D.; Fekete, E.; Hummel, K.P.; and Law, L.W.: The Relation of Mating, Ovulation and the Estrous Smear in the House Mouse to Time of Day, Anat Rec 76: 39-54, 1940.
  • Walker, B.E., and Crain, B., JR.: Effects of Hypervitaminosis A on Palate Development in Two Strains of Mice, Am J Anat 107: 49-58, 1960.[Medline] [Order article via Infotrieve]
  • Walker, B.E., and Fraser, F.C.: Closure of the Secondary Palate in Three Strains of Mice, J Embryol Exp Morphol 4: 176-189, 1956.
  • Walker, B.E., and Quarles, J.: Palate Closure in Embryonic Mice After Excising the Tongue, abstracted, Teratology 7: A30, 1973.

Journal of Dental Research, Vol. 54, No. 6, 1200-1206 (1975)
DOI: 10.1177/00220345750540061701


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B. E. Walker
Palate Morphology and Fetal Movements in Mice After DPH
Journal of Dental Research, July 1, 1979; 58(7): 1740 - 1747.
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This Article
Right arrow Abstract Freely available
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
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Citing Articles
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PubMed
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Right arrow Articles by Walker, B. E.
Right arrow Articles by Quarles, J.
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What's this?